Ligand FADH2

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Basic Ligand Information

Molecular Structure
Picture of FADH2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H35N9O15P2
FADH2
YPZRHBJKEMOYQH-UYBVJOGSSA-N
Synonyms:
FADred, reduced FAD

Show all pahtways known for Show all pathways known for FADH2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (40 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
FADH2 + O2 = FAD + H2O2
show the reaction diagram
asperlicin C + FADH2 + O2 = asperlicin E + FAD + H2O
show the reaction diagram
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3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FADH2 + O2 = 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FAD + H2O
show the reaction diagram
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resorcinol + FADH2 + O2 = hydroxyquinol + FAD + H2O
show the reaction diagram
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2-methylpropanamine + FADH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FAD + H2O
show the reaction diagram
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4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
show the reaction diagram
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(4S)-tetracycline + FADH2 + chloride + O2 + H+ = 7-chloro-(4S)-tetracycline + FAD + 2 H2O
show the reaction diagram
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7-chloro-L-tryptophan + FADH2 + Cl- + O2 + H+ = 6,7-dichloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
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S-(3S)-beta-tyrosyl-[peptidyl-carrier-protein SgcC2]-L-cysteine + 2 FADH2 + 2 H+ + Cl- + O2 = S-(S3)-3-chloro-beta-tyrosyl-[peptidyl-carrier-protein SgcC2]-L-cysteine + FAD + 2 H2O
show the reaction diagram
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5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD
show the reaction diagram
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FADH2 + NAD+ = FAD + NADH + H+
show the reaction diagram
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5,10-methenyltetrahydrofolate + FADH2 = 5,10-methylene tetrahydrofolate + FAD
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-erythritol 4-phosphate + FAD = L-3-tetrulose 4-phosphate + FADH2
show the reaction diagram
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(S)-2-hydroxyglutarate + FAD = 2-oxoglutarate + FADH2
show the reaction diagram
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D-gluconate + FAD = 2-dehydro-D-gluconate + FADH2
show the reaction diagram
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succinate + FAD = fumarate + FADH2
show the reaction diagram
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isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
show the reaction diagram
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glutaryl-CoA + FAD = glutaconyl-CoA + FADH2
show the reaction diagram
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4-androstene-3,17-dione + FAD = 1,4-androstadiene-3,17-dione + FADH2
show the reaction diagram
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glycine + FAD = HCN + CO2 + FADH2
show the reaction diagram
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D-alanine + H2O + FAD = pyruvate + NH3 + FADH2
show the reaction diagram
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FAD + NADH + H+ = FADH2 + NAD+
show the reaction diagram
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FAD + NAD(P)H = FADH2 + NAD(P)+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (180 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
FADH2 + O2 = FAD + H2O2
show the reaction diagram
asperlicin C + FADH2 + O2 = asperlicin E + FAD + H2O
show the reaction diagram
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3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FADH2 + O2 = 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + FAD + H2O
show the reaction diagram
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dibenzothiophene + 2 FADH2 + 2 O2 = dibenzothiophene-5,5-dioxide + 2 FAD + 2 H2O
show the reaction diagram
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ethylenediaminetetraacetate + 2 FADH2 + 2 O2 = ethylenediamine-N,N'-diacetate + 2 glyoxylate + 2 FAD + 2 H2O
show the reaction diagram
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hydroxysqualene + FADH2 = squalene + FAD + H2O
show the reaction diagram
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butanoyl-CoA + FADH2 = butanal + CoA + FAD
show the reaction diagram
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desmosterol + FADH2 = cholesterol + FAD + H+
show the reaction diagram
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5,10-methylenetetrahydrofolate + FADH2 = 5-methyltetrahydrofolate + FAD
show the reaction diagram
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FADH2 + NAD+ = FAD + NADH + H+
show the reaction diagram
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5,10-methylenetetrahydrofolate + FADH2 = 5,10-methylenetetrahydrofolate + FAD
show the reaction diagram
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5,10-methenyltetrahydrofolate + FADH2 = 5,10-methylene tetrahydrofolate + FAD
show the reaction diagram
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FADH2 + nitrate = FAD + nitrite
show the reaction diagram
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nitrite + FADH2 = NH4+ + FAD
show the reaction diagram
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nitrite + FADH2 = NH3 + FAD + H2O
show the reaction diagram
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5,10-methylentetrahydrofolate + uracil1939 in 23S rRNA + FADH2 = tetrahydrofolate + 5-methyluracil1939 in 23S rRNA + FAD
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (110 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-erythritol 4-phosphate + FAD = L-3-tetrulose 4-phosphate + FADH2
show the reaction diagram
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(S)-2-hydroxyglutarate + FAD = 2-oxoglutarate + FADH2
show the reaction diagram
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D-gluconate + FAD = 2-dehydro-D-gluconate + FADH2
show the reaction diagram
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4-phospho-D-erythronate + FAD = 3-hydroxy-4-phosphohydroxy-alpha-ketobutyrate + FADH2
show the reaction diagram
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xanthine + FAD + H2O = urate + FADH2
show the reaction diagram
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formate + FAD = CO2 + FADH2
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formate + FAD = CO2 + FADH2
show the reaction diagram
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formate + FAD = CO2 + FADH2
show the reaction diagram
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FAD + NADH = FADH2 + NAD+
show the reaction diagram
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phenylglyoxylate + FAD + CoA-SH = benzoyl-S-CoA + CO2 + FADH2
show the reaction diagram
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4-hydroxybenzaldehyde + FAD + H2O = 4-hydroxybenzoate + FADH2 + ?
show the reaction diagram
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oxalate + FAD = CO2 + FADH2
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CO + H2O + FAD = CO2 + FADH2
show the reaction diagram
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FAD + NADH + H+ = FADH2 + NAD+
show the reaction diagram
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succinate + FAD = fumarate + FADH2
show the reaction diagram
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isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
show the reaction diagram
-
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glutaryl-CoA + FAD = glutaconyl-CoA + FADH2
show the reaction diagram
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glycine + FAD = HCN + CO2 + FADH2
show the reaction diagram
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FAD + NADH + H+ = FADH2 + NAD+
show the reaction diagram
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FAD + NADPH + H+ = FADH2 + NADP+
show the reaction diagram
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L-proline + FAD + H2O = (S)-1-pyrroline-5-carboxylate + FADH2
show the reaction diagram
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5-methyltetrahydrofolate + FAD = 5,10-methylenetetrahydrofolate + FADH2
show the reaction diagram
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L-proline + FAD = (S)-1-pyrroline-5-carboxylate + FADH2
show the reaction diagram
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2 R-SH + FAD = R-S-S-R + FADH2
show the reaction diagram
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NADH + FAD = NAD+ + FADH2
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (84 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme can use FADH or FMNH2 as flavin cofactor
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contains approximately 1 mol of FAD for each polypeptide chain. The enzyme uses FADH2 as a substrate rather than a cofactor. FADH2 is provided by flavin reductase (NADH)
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; FADH2-utilizing monooxygenase, no reaction with FMNH2
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can donate electrons directly to adenylyl sulfate reductase
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requires the reduced cofactor for activity. The enzyme requires anaerobic conditions for activity. Km: 0.00055 mM
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces activation of StyA1 requiring interprotein communication
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about 50% increase of activity in the presence of FADH2
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activates

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (57 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.28
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2.5
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+ nitrate
0.00001
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References & Links

Links to other databases for FADH2

ChEBI
PubChem
ChEBI
PubChem