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Information on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase

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IUBMB Comments
A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin.
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The expected taxonomic range for this enzyme is: Artemisia
Synonyms
cyp71av1, amorpha-4,11-diene c-12 oxidase, cytochrome p450 monooxygenase 71 av1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
amorpha-4,11-diene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = artemisinate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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overall reaction
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amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
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(1a)
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artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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(1b)
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artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase] = artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
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(1c)
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