Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia annua |
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia afra |
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Artemisia absinthium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia annua | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia afra | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia absinthium | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | Artemisia kurramensis | - |
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Artemisia absinthium | K7ZPJ9 | - |
- |
Artemisia afra | K7ZR99 | - |
- |
Artemisia annua | Q1PS23 | - |
- |
Artemisia kurramensis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Artemisia annua | - |
leaf | - |
Artemisia afra | - |
leaf | - |
Artemisia absinthium | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia annua | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia afra | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia absinthium | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? | |
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] | - |
Artemisia kurramensis | artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP71AV1 | - |
Artemisia annua |
CYP71AV1 | - |
Artemisia afra |
CYP71AV1 | - |
Artemisia absinthium |
CYP71AV1 | - |
Artemisia kurramensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Artemisia annua | |
cytochrome P450 | - |
Artemisia afra | |
cytochrome P450 | - |
Artemisia absinthium | |
cytochrome P450 | - |
Artemisia kurramensis | |
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia annua | |
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia afra | |
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia absinthium | |
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Artemisia kurramensis |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia annua |
metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia afra |
metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia absinthium |
metabolism | the enzyme is involved in the artemisinin biosynthesis | Artemisia kurramensis |
physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia annua |
physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia afra |
physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia absinthium |
physiological function | amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde | Artemisia kurramensis |