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Information on EC 1.13.11.58 - linoleate 9S-lipoxygenase
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1.13.11.58 linoleate 9S-lipoxygenaseIUBMB Comments
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate . EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
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Word Map
- 1.13.11.58
-
linoleic
- oxylipins
-
9-loxs
- lipoxygenases
-
9s-hydroperoxide
-
13-lipoxygenase
-
divinyl
-
colneleic
-
trihydroxy
-
alpha-ketols
- epoxyalcohols
- 12r-lox
-
9s-hydroperoxy-10e,12z-octadecadienoic
- synthesis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
9-lipoxygenase, zmlox3, r9-lox1, zmlox5, calox1, atlox1, epidermal lipoxygenase-3, ghlox1, nb-9-lox, linoleate 9s-lipoxygenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
9-lipoxygenase
9-LOX
CaLOX1
linoleate 9-lipoxygenase
linoleate 9S-lipoxygenase
LOX
LOX1
LOX1.3
LOX12
LOX2
LOX3
LOX4
LOX5
LOX6
r9-LOX1
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
linoleate:oxygen 9-oxidoreductase
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(9E,11Z,14Z)-icosa-9,11,14-trienoic acid + O2
(9S,11Z,14Z)-9-hydroperoxyicosa-11,14-dienoic acid
-
good substrate
-
-
?
12-hydroperoxy-cis,trans,cis-9,13,15-octadecatrienoic acid + O2
12,13-epoxy-14-hydroxy-cis,cis-9,15-octadecadienoic acid
9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid + O2
9,10-epoxy-11-hydroxy-cis,cis-6,12-octadecadienoic acid
9-hydroperoxy-trans,cis-10,12-octadecadienoic acid + O2
9,10-epoxy-11-hydroxy-cis-12-octadecenoic acid
AA/Lyso-PA + O2
15-HPETE/lyso-PA + 13-HPETE/lyso-PA + 15-HPETE/lyso-PA + 11-HPETE/lyso-PA + 5-HPETE/lyso-PA
-
-
36%, 22%, 21% and 13% yield, respectively
-
?
alpha-linolenate
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate is the main product
-
?
alpha-linolenate + O2
?
comparable oxygenase activity with either linoleic acid or linolenic acid
no product determined
-
?
arachidonic acid + O2
5-HPETE + 7-HPETE + 9-HPETE
-
-
22%, 25% and 29% yield, respectively
-
?
gamma-linolenate + O2
(6Z,9S,10E,12Z)-9-hydroperoxy-6,10,12-octadecatrienoate
-
72% (6Z,9S,10E,12Z)-9-hydroperoxy-10,12,15-octadecatrienoate, with racemic 6-, 10-, and 13-gamma-hydroperoxy-(10E,12Z,15Z)-octadecatrienoates as secondary products
-
?
gamma-linolenic acid + O2
9 9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid
-
-
-
-
?
linoleic acid + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
linoleic acid + O2
9-hydroperoxy-trans,cis-10,12-octadecadienoic acid
-
-
-
-
?
linolenic acid + O2
9-hydroperoxy-trans,cis-10,12-octadecadienoic acid
-
-
-
-
?
12-hydroperoxy-cis,trans,cis-9,13,15-octadecatrienoic acid + O2
12,13-epoxy-14-hydroxy-cis,cis-9,15-octadecadienoic acid
-
-
-
-
?
12-hydroperoxy-cis,trans,cis-9,13,15-octadecatrienoic acid + O2
12,13-epoxy-14-hydroxy-cis,cis-9,15-octadecadienoic acid
-
-
-
-
?
9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid + O2
9,10-epoxy-11-hydroxy-cis,cis-6,12-octadecadienoic acid
-
-
-
-
?
9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid + O2
9,10-epoxy-11-hydroxy-cis,cis-6,12-octadecadienoic acid
-
-
-
-
?
9-hydroperoxy-trans,cis-10,12-octadecadienoic acid + O2
9,10-epoxy-11-hydroxy-cis-12-octadecenoic acid
-
-
-
-
?
9-hydroperoxy-trans,cis-10,12-octadecadienoic acid + O2
9,10-epoxy-11-hydroxy-cis-12-octadecenoic acid
-
-
-
-
?
alpha-linolenate + O2
(10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
-
the R/S stereoconfiguration of the product is not determined
-
?
alpha-linolenate + O2
(10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
96% (10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate and 2.1% (9Z,11E,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
?
alpha-linolenate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
alpha-linolenate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
alpha-linolenate + O2
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
12-, 13-, and 16-hydroperoxy-(10E,12Z,15Z)-octadecatrienoates are minor byproducts
-
?
alpha-linolenate + O2
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
comparable oxygenase activity with either linoleic acid or linolenic acid
the enzyme forms exclusively (9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
?
alpha-linolenate + O2
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
-
-
-
-
?
alpha-linolenate + O2
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate
comparable oxygenase activity with either linoleic acid or linolenic acid
more than 96% of the substrate is converted to the the 9-positional hydroperoxide
-
?
alpha-linolenic acid + O2
(10E,12Z)-9-hydroperoxy-10,12,15-octadecatrienoic acid
-
-
-
?
alpha-linolenic acid + O2
(10E,12Z)-9-hydroperoxy-10,12,15-octadecatrienoic acid
-
-
-
-
?
alpha-linolenic acid + O2
12-hydroperoxy-cis,trans,cis-9,13,15-octadecatrienoic acid
-
-
-
-
?
alpha-linolenic acid + O2
12-hydroperoxy-cis,trans,cis-9,13,15-octadecatrienoic acid
-
-
-
-
?
gamma-linoleic acid + O2
9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid
-
-
-
-
?
gamma-linoleic acid + O2
9-hydroperoxy-cis,trans,cis-6,10,12-octadecatrienoic acid
-
-
-
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade
-
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
no formation of 13-hydroperoxy-(10E,12Z)-octadecadienoate. The R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
no formation of 13-hydroperoxy-(10E,12Z)-octadecadienoate. The R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
the R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate is main product. The R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate is main product. The R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
linoleate (abundant in membrane lipids of tubers) is preferred to linolenate as substrate
the R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
recombinant ZmLOX5 protein displays clear 9-LOX regiospecificity at both neutral and slightly alkaline pH
the R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
the main product (94%) is (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate, primarily S configuration
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
the product of the wild-type enzyme is 98.8% (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate and 1.2% (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate. The product of mutant enzyme A562G is 68.9% (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate and 31.1% (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
comparable oxygenase activity with either linoleic acid or linolenic acid
the enzyme forms exclusively (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
regiospecificity of Nb-9-LOX, overview
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
low catalytic activity with complex substrates as compared to free linoleic acid. Residual relative activities lower than 1% with the substrates dilinolein, trilinolein, and 1-palmitoyl-2-linoleoyl-glycero-3-phosphocholine and with extracted lipids from malt confirm this supposition. However, LOX1 catalyzes HPODE formation from PamLinGroPCho with high regioselectivity (9-hydroperoxy-(10E,12Z)-octadecadienoate:13-hydroperoxy-(10E,12Z)-octadecadienoate) and high (9S)-hydroperoxy-(10E,12Z)-octadecadienoate stereoselectivity (S:R) (92:8)
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
the enzyme specifically forms the 9-H(p)ODE isomer by 99.5%, 97.7% of which is in S-form
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
regiospecificity of Nb-9-LOX, overview
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
comparable oxygenase activity with either linoleic acid or linolenic acid
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
the product of the wild-type enzyme is 99.1% (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate and 0.9% (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate. The product of mutant enzyme A564G is 59.9% (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate and 40.1% (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
98% (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate, almost exclusively S stereoconfiguration. (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate is a minor byproduct
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
9-lipoxygenase does not utilize docosadienoic acid and catalyzes eicosadienoic acid dioxygenation 20fold slower than linoleic acid dioxygenation
the enzyme specifically forms the S-stereoisomer
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
from arachidonate the wild-type enzyme forms 47% 11-hydroxyeicosatetraenoic acid, 23% 5-hydroxyeicosatetraenoic acid, 11% 9-hydroxyeicosatetraenoic acid, 9% 12-hydroxyeicosatetraenoic acid, 4.5% 8-hydroxyeicosatetraenoic acid and 4.5% 15-hydroxyeicosatetraenoic acid. Wild-type enzyme converts anandamide mainly to 11S-hydroperoxyanandamide (99.4%). The mutant A562G forms (11S)-hydroperoxyanandamide and (15R)-hydroperoxyanandamide in the ratio 3:2. No activity detected with 1-palmitoyl-2-linoleoylphosphatidylcholine. A model is tested that predicts a relationship between substrate binding orientation and product stereochemistry
-
-
?
additional information
?
-
-
from arachidonate the wild-type enzyme forms 47% 11-hydroxyeicosatetraenoic acid, 23% 5-hydroxyeicosatetraenoic acid, 11% 9-hydroxyeicosatetraenoic acid, 9% 12-hydroxyeicosatetraenoic acid, 4.5% 8-hydroxyeicosatetraenoic acid and 4.5% 15-hydroxyeicosatetraenoic acid. Wild-type enzyme converts anandamide mainly to 11S-hydroperoxyanandamide (99.4%). The mutant A562G forms (11S)-hydroperoxyanandamide and (15R)-hydroperoxyanandamide in the ratio 3:2. No activity detected with 1-palmitoyl-2-linoleoylphosphatidylcholine. A model is tested that predicts a relationship between substrate binding orientation and product stereochemistry
-
-
?
additional information
?
-
low activity with arachidonate, the C20 fatty acid is converted into a mixture of racemic products
-
-
?
additional information
?
-
-
low activity with arachidonate, the C20 fatty acid is converted into a mixture of racemic products
-
-
?
additional information
?
-
in chitosan-treated Adelostemma gracillimum seedlings 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, accumulate
-
-
?
additional information
?
-
-
in chitosan-treated Adelostemma gracillimum seedlings 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, accumulate
-
-
?
additional information
?
-
the enzyme converted linoleic and linolenic acids almost exclusively to their 9-hydroperoxides
-
-
?
additional information
?
-
-
the enzyme converted linoleic and linolenic acids almost exclusively to their 9-hydroperoxides
-
-
?
additional information
?
-
regio- and stereospecificity analysis of isozyme substrate specificity, recombinant LOX1:Md:1a, LOX1:Md:1c, LOX2:Md:2a, and LOX2:Md:2b isozymes show 13/9-LOX, 9-LOX, 13/9-LOX and 13-LOX activity with linoleic acid, respectively. While products of LOX1:Md:1c and LOX2:Md:2b are S-configured, LOX1:Md:1a and LOX2:Md:2a form 13(R)-hydroperoxides as major products. Oxygenation in the carbon backbone of linoleic acid occurs either at carbon atom 9 (9-LOX) or 13 (13-LOX), forming the corresponding hydroperoxy derivatives, respectively. LOX enzymes are not perfectly specific and biocatalysts that produce more than 10% of the alternative regio-isomer are called dual positional specific LOX
-
-
?
additional information
?
-
-
regio- and stereospecificity analysis of isozyme substrate specificity, recombinant LOX1:Md:1a, LOX1:Md:1c, LOX2:Md:2a, and LOX2:Md:2b isozymes show 13/9-LOX, 9-LOX, 13/9-LOX and 13-LOX activity with linoleic acid, respectively. While products of LOX1:Md:1c and LOX2:Md:2b are S-configured, LOX1:Md:1a and LOX2:Md:2a form 13(R)-hydroperoxides as major products. Oxygenation in the carbon backbone of linoleic acid occurs either at carbon atom 9 (9-LOX) or 13 (13-LOX), forming the corresponding hydroperoxy derivatives, respectively. LOX enzymes are not perfectly specific and biocatalysts that produce more than 10% of the alternative regio-isomer are called dual positional specific LOX
-
-
?
additional information
?
-
-
Nb-9-LOX possesses both 9-lipoxygenase and 13-lipoxygenase, EC 1.13.11.12, specificity, with high predominance for the 9-LOX function
-
-
?
additional information
?
-
from arachidonate the wild-type enzyme forms 11-hydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid in essentially equal amounts (38-39%), 11% 8-hydroxyeicosatetraenoic acid, 4% 12-hydroxyeicosatetraenoic acid, 3% 15-hydroxyeicosatetraenoic acid and 2% 9-hydroxyeicosatetraenoic acid. Wild-type enzyme converts anandamide mainly to (11S)-hydroperoxyanandamide (71%), plus 16% (5S)-hydroperoxyanandamide. The mutant enzyme A564G forms two additional prominent products, 15-hydroperoxyanandamide (34%) and 9-hydroperoxyanandamide (19%). No activity detected with 1-palmitoyl-2-linoleoylphosphatidylcholine. A model is tested that predicts a relationship between substrate binding orientation and product stereochemistry
-
-
?
additional information
?
-
-
from arachidonate the wild-type enzyme forms 11-hydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid in essentially equal amounts (38-39%), 11% 8-hydroxyeicosatetraenoic acid, 4% 12-hydroxyeicosatetraenoic acid, 3% 15-hydroxyeicosatetraenoic acid and 2% 9-hydroxyeicosatetraenoic acid. Wild-type enzyme converts anandamide mainly to (11S)-hydroperoxyanandamide (71%), plus 16% (5S)-hydroperoxyanandamide. The mutant enzyme A564G forms two additional prominent products, 15-hydroperoxyanandamide (34%) and 9-hydroperoxyanandamide (19%). No activity detected with 1-palmitoyl-2-linoleoylphosphatidylcholine. A model is tested that predicts a relationship between substrate binding orientation and product stereochemistry
-
-
?
additional information
?
-
low activity with arachidonate, the C20 fatty acid is converted into a mixture of racemic products
-
-
?
additional information
?
-
-
low activity with arachidonate, the C20 fatty acid is converted into a mixture of racemic products
-
-
?
additional information
?
-
-
the enzyme catalyzes oxygenation at the n-12 position of C20 and C22 polyunsaturated fatty acids to form 9S- and 11S-hydroperoxy fatty acids, which are reduced to 9S- and 11S-hydroxy fatty acids by cysteine, respectively, and it catalyzes again oxygenation at the n-6 position of 11S-hydroxy fatty acids to form 9S,15S- and 11S,17S-dihydroxy fatty acids, respectively
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-linolenate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
alpha-linolenate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
alpha-linolenic acid + O2
(10E,12Z)-9-hydroperoxy-10,12,15-octadecatrienoic acid
-
-
-
?
alpha-linolenic acid + O2
(10E,12Z)-9-hydroperoxy-10,12,15-octadecatrienoic acid
-
-
-
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade
-
-
?
linoleate + O2
(10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
regiospecificity of Nb-9-LOX, overview
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
?
linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
-
-
-
-
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linoleate + O2
(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
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in chitosan-treated Adelostemma gracillimum seedlings 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, accumulate
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additional information
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in chitosan-treated Adelostemma gracillimum seedlings 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, accumulate
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Nb-9-LOX possesses both 9-lipoxygenase and 13-lipoxygenase, EC 1.13.11.12, specificity, with high predominance for the 9-LOX function
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-[5-(2-phenyl-1H-indol-3-yl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
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2-phenyl-3-[3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-1H-indole
most potent inhibitor tested
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ethyl 2-[(2E)-2-benzylidenehydrazinyl]-4-methyl-1,3-thiazole-5-carboxylate
compound exhibits dual inhibitory activity against both 15-LOX and bovine carbonic anhydrase II
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ethyl 4-methyl-2-[(2E)-2-[(3-nitrophenyl)methylidene]hydrazinyl]-1,3-thiazole-5-carboxylate
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additional information
not inhibitory: O-geranyl substituents at positions 5 and 6 of 3-acetylcoumarin
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Dehydration
Specific adduction of plant lipid transfer protein by an allene oxide generated by 9-lipoxygenase and allene oxide synthase.
Infections
Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections.
Infections
Identification of MAPKs as signal transduction components required for the cell death response during compatible infection by the synergistic pair Potato virus X-Potato virus Y.
Infections
Lipid peroxidation during the hypersensitive response in potato in the absence of 9-lipoxygenases.
Infections
Oxylipin biosynthesis genes positively regulate PCD during compatible infections by the synergistic pair Potato virus X-Potato virus Y and by Tomato spotted wilt virus.
Infections
Oxylipins from both pathogen and host antagonize jasmonic acid-mediated defence via the 9-lipoxygenase pathway in Fusarium verticillioides infection of maize.
Infections
Reduction of divinyl ether-containing polyunsaturated fatty acids in transgenic potato plants.
Infections
The pepper 9-lipoxygenase gene CaLOX1 functions in defense and cell death responses to microbial pathogens.
Infections
The pepper lipoxygenase CaLOX1 plays a role in osmotic, drought, and high salinity.
Infections
Transcriptional Changes of Plant Defense-Related Genes in Response to Clavibacter Infection in Pepper and Tomato.
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KM VALUE [mM]
SUBSTRATE
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COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE