Literature summary for 1.13.11.58 extracted from

Saeed, A.; Khan, S.U.; Mahesar, P.A.; Channar, P.A.; Shabir, G.; Iqbal, J.
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II synthesis, biochemical evaluation and docking studies (2017), Biochem. Biophys. Res. Commun., 482, 176-181 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
ethyl 2-[(2E)-2-benzylidenehydrazinyl]-4-methyl-1,3-thiazole-5-carboxylate	compound exhibits dual inhibitory activity against both 15-LOX and bovine carbonic anhydrase II	Glycine max
ethyl 4-methyl-2-[(2E)-2-[(3-nitrophenyl)methylidene]hydrazinyl]-1,3-thiazole-5-carboxylate	-	Glycine max

Organism

Organism	UniProt	Comment	Textmining
Glycine max	P09186	-	-

Synonyms

Synonyms	Comment	Organism
15-LOX	-	Glycine max
LOX1.3	-	Glycine max

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00012	-	pH 8.0, 25°C	Glycine max	ethyl 2-[(2E)-2-benzylidenehydrazinyl]-4-methyl-1,3-thiazole-5-carboxylate
0.00021	-	pH 8.0, 25°C	Glycine max	ethyl 4-methyl-2-[(2E)-2-[(3-nitrophenyl)methylidene]hydrazinyl]-1,3-thiazole-5-carboxylate

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Release 2023.1 (January 2023)