Literature summary for 1.13.11.58 extracted from

Kim, S.E.; Lee, J.; An, J.U.; Kim, T.H.; Oh, C.W.; Ko, Y.J.; Krishnan, M.; Choi, J.; Yoon, D.Y.; Kim, Y.; Oh, D.K.
Regioselectivity of an arachidonate 9S-lipoxygenase from Sphingopyxis macrogoltabida that biosynthesizes 9S,15S- and 11S,17S-dihydroxy fatty acids from C20 and C22 polyunsaturated fatty acids (2022), Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1867, 159091 .

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Protein Variants

Protein Variants	Comment	Organism
I395F	the regioselectivity of the variant is changed from the n-12 position on C20 PUFA to the n-6 position to form 15S-HFAs	Sphingopyxis macrogoltabida
V569W	the variant has a significantly lower secondx1eoxygenating activity compared to wild type enzyme	Sphingopyxis macrogoltabida

Organism

Organism	UniProt	Comment	Textmining
Sphingopyxis macrogoltabida	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme catalyzes oxygenation at the n-12 position of C20 and C22 polyunsaturated fatty acids to form 9S- and 11S-hydroperoxy fatty acids, which are reduced to 9S- and 11S-hydroxy fatty acids by cysteine, respectively, and it catalyzes again oxygenation at the n-6 position of 11S-hydroxy fatty acids to form 9S,15S- and 11S,17S-dihydroxy fatty acids, respectively	Sphingopyxis macrogoltabida	?	-	-

Synonyms

Synonyms	Comment	Organism
arachidonate 9S-LOX	-	Sphingopyxis macrogoltabida

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Release 2023.1 (January 2023)