Information on EC 1.12.7.2 - ferredoxin hydrogenase

Reaction Schemes

hideshow

H2

+

oxidized ferredoxin

=

reduced ferredoxin

+

2

H+

+

=

+

2

Synonyms
membrane-bound hydrogenase, hydrogenase i, bidirectional hydrogenase, hydrogenlyase, fe-fe hydrogenase, [fefe] hydrogenase hyda1, c-mbh, ddhydab, ferredoxin-dependent [fefe]-hydrogenase, mbh hydrogenase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

bidirectional hydrogenase

-

-

-

-

C-MBH

Pyrococcus furiosus

Q8U0Z8; Q8U0Z7; Q8U0Z6

engineered minimal catalytically active 4-subunit subcomplex of respiratory membrane-bound hydrogenase

730867

CooH

Rubrivivax gelatinosus

-

gene name, ec 1.12.7.2

765194

CpI

Clostridium pasteurianum

-

-

711817

DDH

Desulfovibrio desulfuricans

-

-

711817

DdHydAB

Desulfovibrio desulfuricans

-

-

765440

EC 1.12.1.1

-

-

formerly

-

EC 1.12.7.1

-

-

formerly

-

EC 1.18.3.1

-

-

formerly

-

EC 1.18.99.1

-

-

formerly

-

EC 1.98.1.1

-

-

formerly

-

Ech hydrogenase

6 entries

EHb

Methanococcus maripaludis

-

-

712301

EhbM

Methanococcus maripaludis

-

small subunit of energy-conserving hydrogenase B

712301

EhbN

Methanococcus maripaludis

-

large subunit of energy-conserving hydrogenase B

712301

energy-conserving hydrogenase B

Methanococcus maripaludis

-

-

712301

energy-converting hydrogenase

2 entries

Fe hydrogenlyase

-

-

-

-

Fe-Fe hydrogenase

Clostridium acetobutylicum

-

-

684643

Fe-H2ase

Enterobacter cloacae

-

-

704088

Fe-hydrogenase

Enterobacter cloacae

-

-

704088

ferredoxin-dependent [FeFe] hydrogenase

2 entries

ferredoxin-dependent [FeFe]-hydrogenase

Ruminococcus albus

-

-

742784

H2 oxidizing hydrogenase

-

-

-

-

H2 producing hydrogenase [ambiguous]

-

-

-

-

HYD1

-

-

-

-

HYD2

-

-

-

-

hydA

8 entries

HydA1

5 entries

HydA2

3 entries

hydrogen-lyase [ambiguous]

-

-

-

-

hydrogenase (ferredoxin)

-

-

-

-

hydrogenase I

-

-

-

-

hydrogenase II

-

-

-

-

hydrogenase of the Fe-only type

Chlamydomonas reinhardtii

-

-

711817

hydrogenlyase

-

-

-

-

hydrogenlyase [ambiguous]

-

-

-

-

Mbh

Pyrococcus furiosus

-

-

659110

MBH hydrogenase

2 entries

MbhJ

Pyrococcus furiosus

Q8U0Z8

subunit of membrane-bound hydrogenase

722171

MbhJKLN

Pyrococcus furiosus

Q8U0Z8; Q8U0Z7; Q8U0Z6

engineered minimal catalytically active 4-subunit subcomplex of respiratory membrane-bound hydrogenase, MbhJKLN

730867

MbhK

Pyrococcus furiosus

Q8U0Z7

membrane-bound hydrogenase subunit beta

722171

MbhL

Pyrococcus furiosus

Q8U0Z6

membrane-bound hydrogenase subunit alpha

722171

MDH

2 entries

membrane bound NiFe hydrogenase

Pyrococcus furiosus

-

-

659110

membrane-bound hydrogenase

2 entries

NiFe hydrogenase

-

-

-

-

reversible Fe-hydrogenase

Chlamydomonas reinhardtii

-

-

660222

uptake hydrogenase [ambiguous]

-

-

-

-

[FeFe] hydrogenase

10 entries

[FeFe] hydrogenase HydA1

Chlamydomonas reinhardtii

Q9FYU1

-

764969

[FeFe]-hydrogenase

7 entries

[Fe]-hydrogenase

Enterobacter cloacae

-

-

704088

[Ni-Fe] hydrogenase

2 entries

[NiFeSe] Hase

Desulfovibrio vulgaris

-

-

701537

[NiFeSe] hydrogenase

Desulfovibrio vulgaris

-

-

701537

Ech hydrogenase

Caldanaerobacter subterraneus subsp. tengcongensis

-

-

656734

Ech hydrogenase

Methanosarcina barkeri

-

-

659110, 673529

Ech hydrogenase

Methanosarcina mazei

-

-

712307, 727467

Ech hydrogenase

Methanosarcina mazei DSM 3647

-

-

-

Ech hydrogenase

Rubrivivax gelatinosus

-

ec 1.12.7.2

765194

Ech hydrogenase

Rubrivivax gelatinosus CBS

-

ec 1.12.7.2

-

energy-converting hydrogenase

Rubrivivax gelatinosus

-

-

765194

energy-converting hydrogenase

Rubrivivax gelatinosus CBS

-

-

-

ferredoxin-dependent [FeFe] hydrogenase

Thermotoga maritima

-

-

712281

ferredoxin-dependent [FeFe] hydrogenase

Thermotoga maritima DSM 3109

-

-

-

hydA

Chlorococcum submarinum

-

-

711817

hydA

Clostridium acetobutylicum

-

-

684643, 711817, 764411

hydA

Clostridium acetobutylicum NBRC 13948

-

-

-

hydA

Megasphaera elsdenii

-

-

711817

hydA

Rhodospirillum rubrum

-

-

742698

hydA

Rhodospirillum rubrum UR1

-

-

-

hydA

Tetradesmus obliquus

-

-

711817

hydA

[Chlorella] fusca

-

-

711817

HydA1

Chlamydomonas moewusii

-

-

711817

HydA1

Chlamydomonas reinhardtii

-

-

742279

HydA1

Chlamydomonas reinhardtii

-

isozyme

711817

HydA1

Chlamydomonas reinhardtii

Q9FYU1

-

684463

HydA1

Clostridium acetobutylicum

-

-

686267, 686793

HydA2

Chlamydomonas reinhardtii

-

-

685620, 705334

HydA2

Chlamydomonas reinhardtii

-

isozyme

711817

HydA2

Ruminococcus albus

-

-

742784

MBH hydrogenase

Rubrivivax gelatinosus

-

ec 1.12.7.2

765194

MBH hydrogenase

Rubrivivax gelatinosus CBS

-

ec 1.12.7.2

-

MDH

Pyrococcus furiosus

-

-

742859

MDH

Pyrococcus furiosus COM1

-

-

-

membrane-bound hydrogenase

Pyrococcus furiosus

-

-

742859

membrane-bound hydrogenase

Pyrococcus furiosus COM1

-

-

-

[FeFe] hydrogenase

Chlamydomonas moewusii

-

-

711817

[FeFe] hydrogenase

Chlamydomonas reinhardtii

-

-

685620, 685627, 711817, 742279

[FeFe] hydrogenase

Chlamydomonas reinhardtii

Q9FYU1

-

684463

[FeFe] hydrogenase

Chlorococcum submarinum

-

-

711817

[FeFe] hydrogenase

Clostridium acetobutylicum

-

-

711817

[FeFe] hydrogenase

Clostridium pasteurianum

-

-

711817

[FeFe] hydrogenase

Desulfovibrio desulfuricans

-

-

711817, 765440

[FeFe] hydrogenase

Megasphaera elsdenii

-

-

711817

[FeFe] hydrogenase

Tetradesmus obliquus

-

-

711817

[FeFe] hydrogenase

[Chlorella] fusca

-

-

711817

[FeFe]-hydrogenase

Chlamydomonas reinhardtii

-

-

705334

[FeFe]-hydrogenase

Clostridium acetobutylicum

-

-

686267, 686793, 764411

[FeFe]-hydrogenase

Clostridium acetobutylicum NBRC 13948

-

-

-

[FeFe]-hydrogenase

Rhodospirillum rubrum

-

-

742698

[FeFe]-hydrogenase

Rhodospirillum rubrum UR1

-

-

-

[FeFe]-hydrogenase

Thermotoga maritima

-

-

712281

[FeFe]-hydrogenase

Thermotoga maritima DSM 3109

-

-

-

[Ni-Fe] hydrogenase

Tetraselmis sp. KSN-2002

-

-

688848

[Ni-Fe] hydrogenase

Tetraselmis sp. KSN-2002 NCIM 1605

-

-

-

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

H2 + oxidized ferredoxin = reduced ferredoxin + 2 H+

-

-

-

-

top print hide show all columns Go to Reaction Type Search

REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

-

-

-

-

redox reaction

-

-

-

-

reduction

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

BRENDA

hydrogen production

MetaCyc

hydrogen production III, hydrogen production VI, hydrogen production VIII, L-glutamate degradation VII (to butanoate), superpathway of fermentation (Chlamydomonas reinhardtii)

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SYSTEMATIC NAME

IUBMB Comments

hydrogen:ferredoxin oxidoreductase

Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.

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CAS REGISTRY NUMBER

COMMENTARY

9080-02-8

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

(SeO3)2- + H2 + ?

Se + H2O + ?

2 entries

(TeO3)2- + H2 + ?

Te + H2O + ?

2 entries

2 H+ + reduced ferredoxin

H2 + oxidized ferredoxin

2 entries

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

6 entries

H+ + NADH

H2 + NAD+

Pyrococcus furiosus

-

439641

Substrates: -
Products: -

r

H+ + reduced benzyl viologen

H2 + oxidized benzyl viologen

Enterobacter cloacae

-

704088

Substrates: 58.8% relative activity, purified enzyme
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

23 entries

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

9 entries

H2 + 2 oxidized ferredoxin

2 reduced ferredoxin + 2 H+

Pyrococcus furiosus

Q8U0Z8; Q8U0Z7; Q8U0Z6

730867

Substrates: -
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

62 entries

H2 + ferredoxin + oxidized metronidazole

H+ + ferredoxin + reduced metronidazole

2 entries

H2 + methyl viologen

reduced methyl viologen + H+

4 entries

H2 + NAD+

H+ + NADH

Pyrococcus furiosus

-

439641

Substrates: -
Products: -

r

H2 + oxidized benzyl viologen

H+ + reduced benzyl viologen

2 entries

H2 + oxidized benzyl viologen

reduced benzyl viologen + H+

Methanosarcina barkeri

-

673529

Substrates: wild-type enzyme catalysed the reduction of benzylviologen at fourfold higher rates than the reduction of ferredoxin
Products: -

?

H2 + oxidized CAC3527 ferredoxin

H+ + reduced CAC3527 ferredoxin

Clostridium acetobutylicum

-

686267

Substrates: mutant CAC3527 ferredoxin displays an almost 8fold lower reduction potential than wild type ferredoxin
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

19 entries

H2 + oxidized ferredoxin

reduced ferredoxin + 2 H+

Chlamydomonas reinhardtii

-

705334

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

9 entries

H2 + oxidized ferredoxin CAC0587

H+ + reduced ferredoxin CAC0587

Clostridium acetobutylicum

-

686793

Substrates: ferredoxin CAC0587 is the standard major ferredoxin
Products: -

r

H2 + oxidized ferredoxin Pet F

reduced ferredoxin Pet F + H+

Chlamydomonas reinhardtii

-

742279

Substrates: -
Products: -

?

H2 + oxidized flavodoxin CAC0587

H+ + reduced flavodoxin CAC0587

Clostridium acetobutylicum

-

686793

Substrates: flavodoxin CAC0587 is the standard major flavodoxin
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

10 entries

H2 + oxidized methylene blue

H+ + reduced methylene blue

2 entries

H2 + oxidized spinach ferredoxin

reduced spinach ferredoxin + H+

2 entries

S + NADPH

H2S + NADP+

Pyrococcus furiosus

-

439641, 439664

Substrates: -
Products: -

?

additional information

?

-

6 entries

(SeO3)2- + H2 + ?

Se + H2O + ?

Clostridium pasteurianum

-

439661

Substrates: methyl viologen and benzyl viologen as electron acceptors
Products: -

?

(SeO3)2- + H2 + ?

Se + H2O + ?

Clostridium pasteurianum W5

-

439661

Substrates: methyl viologen and benzyl viologen as electron acceptors
Products: -

?

(TeO3)2- + H2 + ?

Te + H2O + ?

Clostridium pasteurianum

-

439661

Substrates: methyl viologen as electron acceptor
Products: -

?

(TeO3)2- + H2 + ?

Te + H2O + ?

Clostridium pasteurianum W5

-

439661

Substrates: methyl viologen as electron acceptor
Products: -

?

2 H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Caldanaerobacter subterraneus subsp. tengcongensis

-

675496

Substrates: -
Products: -

?

2 H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Caldanaerobacter subterraneus subsp. tengcongensis

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Carboxydothermus hydrogenoformans

-

675496

Substrates: -
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Carboxydothermus hydrogenoformans

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Escherichia coli

-

675496

Substrates: -
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Escherichia coli

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Rhodospirillum rubrum

-

675496

Substrates: -
Products: -

?

2 H+ + reduced polyferredoxin

H2 + oxidized polyferredoxin

Rhodospirillum rubrum

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Caldanaerobacter subterraneus subsp. tengcongensis

-

659110

Substrates: -
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Caldanaerobacter subterraneus subsp. tengcongensis

-

656734

Substrates: -
Products: -

r

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Caldanaerobacter subterraneus subsp. tengcongensis

-

659110

Substrates: reaction is proposed to be coupled to energy conservation
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Chlamydomonas moewusii

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Chlamydomonas reinhardtii

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Chlorococcum submarinum

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Clostridium acetobutylicum

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Clostridium pasteurianum

-

439669

Substrates: -
Products: -

r

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Clostridium pasteurianum

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Desulfovibrio desulfuricans

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Enterobacter cloacae

-

704088

Substrates: 94.3% relative activity, purified enzyme
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Megasphaera elsdenii

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina barkeri

-

675496

Substrates: -
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina barkeri

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina mazei

-

727467

Substrates: -
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina mazei

-

727467

Substrates: Ech hydrogenase acts as primary proton pump in a ferredoxin-dependent electron transport system. Ech hydrogenase is necessary to generate an electrochemical ion gradient when ferredoxin is the only reducing equivalent and heterodisulfide is absent
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina mazei DSM 3647

-

727467

Substrates: -
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Methanosarcina mazei DSM 3647

-

727467

Substrates: Ech hydrogenase acts as primary proton pump in a ferredoxin-dependent electron transport system. Ech hydrogenase is necessary to generate an electrochemical ion gradient when ferredoxin is the only reducing equivalent and heterodisulfide is absent
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Pyrococcus furiosus

-

659110, 675496

Substrates: -
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Pyrococcus furiosus

-

659110

Substrates: Mbh function as a redox-driven ion pump coupling the reduction of protons with electrons derived from the oxidation of a low-potential ferredoxin to the generation of a H+ motive force
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Pyrococcus furiosus

-

675496

Substrates: the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

Tetradesmus obliquus

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced ferredoxin

H2 + oxidized ferredoxin

[Chlorella] fusca

-

711817

Substrates: hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Caldanaerobacter subterraneus subsp. tengcongensis

-

656734

Substrates: -
Products: -

r

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Chlamydomonas reinhardtii

-

439665, 711817

Substrates: -
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Chlamydomonas reinhardtii 137 C(+)

-

439665

Substrates: -
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Clostridium acetobutylicum

-

764411

Substrates: -
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Clostridium acetobutylicum NBRC 13948

-

764411

Substrates: -
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Clostridium pasteurianum

-

439669, 439682

Substrates: -
Products: -

r

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Clostridium pasteurianum W5

-

439682

Substrates: -
Products: -

r

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Enterobacter cloacae

-

704088

Substrates: 100% relative activity, purified enzyme
Products: -

?

H+ + reduced methyl viologen

H2 + oxidized methyl viologen

Pyrococcus furiosus

-

439641, 659110

Substrates: -
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Acidithiobacillus ferrooxidans

-

439660

Substrates: ferricyanide as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Acidithiobacillus ferrooxidans

-

439660

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Acidithiobacillus ferrooxidans ATC 19859

-

439660

Substrates: ferricyanide as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Acidithiobacillus ferrooxidans ATC 19859

-

439660

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii

-

439672

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii

-

439665

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii

-

439672

Substrates: sulfonatopropyl viologen, sodium metatungstate and sodium silicotungstate as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii 137 C(+)

-

439665

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii 137 C(+)

-

439672

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Chlamydomonas reinhardtii 137 C(+)

-

439672

Substrates: sulfonatopropyl viologen, sodium metatungstate and sodium silicotungstate as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439668

Substrates: -
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439669, 439670, 439679, 439681, 439682, 439684

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439671

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439669, 439675, 439679, 439681, 439682, 439684

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439671, 439678

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439681

Substrates: FAD and FMN as electron acceptors
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439671

Substrates: FAD, FMN or riboflavin as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439679, 439682

Substrates: benzyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439671

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum

-

439679, 439681

Substrates: dichlorophenol indophenol as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439669

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439669

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439671

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439671

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439671

Substrates: FAD, FMN or riboflavin as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439671

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439679

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439679

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439679

Substrates: benzyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439679

Substrates: dichlorophenol indophenol as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439681

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439681

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439681

Substrates: FAD and FMN as electron acceptors
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439681

Substrates: dichlorophenol indophenol as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439682

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439682

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439682

Substrates: benzyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439684

Substrates: methylene blue as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Clostridium pasteurianum W5

-

439684

Substrates: methyl viologen as electron acceptor
Products: -

?

H2 + electron acceptor

H+ + reduced electron acceptor

Desulfovibrio vulgaris

-

439651

Substrates: -
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Megasphaera elsdenii

-

439674, 439677

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Megasphaera elsdenii

-

439674, 439677

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Megasphaera elsdenii LC1

-

439677

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Megasphaera elsdenii LC1

-

439677

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri

-

439643, 439663

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri

-

439663

Substrates: cytochrome b as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri

-

439643, 439663

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri

-

439663

Substrates: phenosafranine as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri

-

439663

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri MS / DSM 800

-

439663

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri MS / DSM 800

-

439663

Substrates: cytochrome b as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri MS / DSM 800

-

439663

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri MS / DSM 800

-

439663

Substrates: phenosafranine as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Methanosarcina barkeri MS / DSM 800

-

439663

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Pyrococcus furiosus

-

439632

Substrates: methylene blue as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Pyrococcus furiosus

-

439632, 439641, 439652

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Pyrococcus furiosus

-

439641, 439652

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Pyrococcus furiosus

-

439641, 439652

Substrates: NADP+ as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Sporomusa sphaeroides

-

439659

Substrates: cytochrome b as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Sporomusa sphaeroides

-

439659

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Sporomusa sphaeroides

-

439659

Substrates: benzyl viologen as electron acceptor
Products: -

r

H2 + electron acceptor

H+ + reduced electron acceptor

Tetradesmus obliquus

-

439650

Substrates: methyl viologen as electron acceptor
Products: -

r

H2 + ferredoxin + oxidized metronidazole

H+ + ferredoxin + reduced metronidazole

Caldanaerobacter subterraneus subsp. tengcongensis

-

656734

Substrates: -
Products: -

?

H2 + ferredoxin + oxidized metronidazole

H+ + ferredoxin + reduced metronidazole

Methanosarcina barkeri

-

673529

Substrates: -
Products: -

?

H2 + methyl viologen

reduced methyl viologen + H+

Pyrococcus furiosus

-

742859

Substrates: -
Products: -

?

H2 + methyl viologen

reduced methyl viologen + H+

Pyrococcus furiosus COM1

-

742859

Substrates: -
Products: -

?

H2 + methyl viologen

reduced methyl viologen + H+

Rhodospirillum rubrum

-

742698

Substrates: -
Products: -

?

H2 + methyl viologen

reduced methyl viologen + H+

Rhodospirillum rubrum UR1

-

742698

Substrates: -
Products: -

?

H2 + oxidized benzyl viologen

H+ + reduced benzyl viologen

Megasphaera elsdenii

-

439674, 439677

Substrates: -
Products: -

r

H2 + oxidized benzyl viologen

H+ + reduced benzyl viologen

Megasphaera elsdenii LC1

-

439677

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Alvikia littoralis

-

439654

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Chlamydomonas reinhardtii

-

685620, 685627

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Chlamydomonas reinhardtii

-

439665, 439672

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Chlamydomonas reinhardtii 137 C(+)

-

439665, 439672

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Clostridium acetobutylicum

-

686267

Substrates: 2[4Fe4S] ferredoxin
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Clostridium acetobutylicum

-

684643

Substrates: under anoxic conditions
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Clostridium pasteurianum

-

439669, 439671, 439675, 439679, 439682

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Clostridium pasteurianum W5

-

439669, 439671, 439679, 439682

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Megasphaera elsdenii

-

439677

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Megasphaera elsdenii LC1

-

439677

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Methanococcus maripaludis

-

712301

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Methanosarcina barkeri

-

439643

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Methanosarcina mazei

-

712307

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Pyrococcus furiosus

-

439632

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Tetradesmus obliquus

-

439650

Substrates: ferredoxin links the enzyme to photosynthesis
Products: -

r

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Tetraselmis sp. KSN-2002

-

688848

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Tetraselmis sp. KSN-2002 NCIM 1605

-

688848

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Thermotoga maritima

-

712281

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

H+ + reduced ferredoxin

Thermotoga maritima DSM 3109

-

712281

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Chlamydomonas reinhardtii

-

660222

Substrates: -
Products: -

r

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Chlamydomonas reinhardtii

-

660222

Substrates: enzyme activity is induced in the dark under anaerobic growth conditions
Products: -

r

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Methanosarcina barkeri

-

659110

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Methanosarcina barkeri

-

659110

Substrates: enzyme is absolutely required for the reduction of CO2 to formylmethanofuran by H2, Ech hydrogenase provides the cell with reduced ferredoxin required as electron donor
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Pyrococcus furiosus

-

742859

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Pyrococcus furiosus COM1

-

742859

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Rhodospirillum rubrum

-

742698

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Rhodospirillum rubrum UR1

-

742698

Substrates: -
Products: -

?

H2 + oxidized ferredoxin

reduced ferredoxin + H+

Ruminococcus albus

-

742784

Substrates: -
Products: -

?

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Alvikia littoralis

-

439654

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Clostridium acetobutylicum

-

684643, 686267, 686793

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Clostridium pasteurianum

-

439669

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Clostridium pasteurianum W5

-

439669

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Megasphaera elsdenii

-

439677

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Megasphaera elsdenii LC1

-

439677

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Methanococcus maripaludis

-

712301

Substrates: -
Products: -

?

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Tetradesmus obliquus

-

439650

Substrates: -
Products: -

r

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Tetraselmis sp. KSN-2002

-

688848

Substrates: -
Products: -

?

H2 + oxidized methyl viologen

H+ + reduced methyl viologen

Tetraselmis sp. KSN-2002 NCIM 1605

-

688848

Substrates: -
Products: -

?

H2 + oxidized methylene blue

H+ + reduced methylene blue

Clostridium pasteurianum

-

439669

Substrates: -
Products: -

r

H2 + oxidized methylene blue

H+ + reduced methylene blue

Clostridium pasteurianum W5

-

439669

Substrates: -
Products: -

r

H2 + oxidized spinach ferredoxin

reduced spinach ferredoxin + H+

Rhodospirillum rubrum

-

742698

Substrates: -
Products: -

?

H2 + oxidized spinach ferredoxin

reduced spinach ferredoxin + H+

Rhodospirillum rubrum UR1

-

742698

Substrates: -
Products: -

?

additional information

?

-

Desulfovibrio desulfuricans

-

765440

Substrates: electrodes modified with [FeFe] hydrogenase from Desulfovibrio desulfuricans (DdHydAB) catalyse both H2 oxidation and production under conditions of direct electron transfer or mediated electron transfer within the film of polymer PV2. Reversibility in electrocatalytic films is important for energy conversion applications because it combines the advantage of high current densities at low overpotential with the possibility for robust