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EC 2.7.1.91 Details

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EC number

2.7.1.91

Accepted name

sphingosine kinase

Reaction

ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate

Other name(s)

SPHK1 (gene name), SPHK2 (gene name), dihydrosphingosine kinase, dihydrosphingosine kinase (phosphorylating), sphingosine kinase (phosphorylating), sphingoid base kinase, sphinganine kinase, ATP:sphinganine 1-phosphotransferase

Systematic name

ATP:sphingoid base 1-phosphotransferase

CAS registry number

50864-48-7

Comment

The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.

History

created 1976, modified 1980, modified 2016

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.1 hexokinase

2.7.1.2 glucokinase

2.7.1.3 ketohexokinase

2.7.1.4 fructokinase

2.7.1.5 rhamnulokinase

2.7.1.6 galactokinase

2.7.1.7 mannokinase

2.7.1.8 glucosamine kinase

2.7.1.9 created 1961, deleted 1965

2.7.1.10 phosphoglucokinase

2.7.1.11 6-phosphofructokinase

2.7.1.12 gluconokinase

2.7.1.13 dehydrogluconokinase

2.7.1.14 sedoheptulokinase

2.7.1.15 ribokinase

2.7.1.16 ribulokinase

2.7.1.17 xylulokinase

2.7.1.18 phosphoribokinase

2.7.1.19 phosphoribulokinase

2.7.1.20 adenosine kinase

2.7.1.21 thymidine kinase

2.7.1.22 ribosylnicotinamide kinase

2.7.1.23 NAD⁺ kinase

2.7.1.24 dephospho-CoA kinase

2.7.1.25 adenylyl-sulfate kinase

2.7.1.26 riboflavin kinase

2.7.1.27 erythritol kinase (D-erythritol 4-phosphate-forming)

2.7.1.28 triokinase

2.7.1.29 glycerone kinase

2.7.1.30 glycerol kinase

2.7.1.31 glycerate 3-kinase

2.7.1.32 choline kinase

2.7.1.33 pantothenate kinase

2.7.1.34 pantetheine kinase

2.7.1.35 pyridoxal kinase

2.7.1.36 mevalonate kinase

2.7.1.37 protein kinase

2.7.1.38 phosphorylase kinase

2.7.1.39 homoserine kinase

2.7.1.40 pyruvate kinase

2.7.1.41 glucose-1-phosphate phosphodismutase

2.7.1.42 riboflavin phosphotransferase

2.7.1.43 glucuronokinase

2.7.1.44 galacturonokinase

2.7.1.45 2-dehydro-3-deoxygluconokinase

2.7.1.46 L-arabinokinase

2.7.1.47 D-ribulokinase

2.7.1.48 uridine/cytidine kinase

2.7.1.49 hydroxymethylpyrimidine kinase

2.7.1.50 hydroxyethylthiazole kinase

2.7.1.51 L-fuculokinase

2.7.1.52 fucokinase

2.7.1.53 L-xylulokinase

2.7.1.54 D-arabinokinase

2.7.1.55 allose kinase

2.7.1.56 1-phosphofructokinase

2.7.1.57 created 1972, deleted 1984

2.7.1.58 2-dehydro-3-deoxygalactonokinase

2.7.1.59 N-acetylglucosamine kinase

2.7.1.60 N-acylmannosamine kinase

2.7.1.61 acyl-phosphate—hexose phosphotransferase

2.7.1.62 phosphoramidate—hexose phosphotransferase

2.7.1.63 polyphosphate—glucose phosphotransferase

2.7.1.64 inositol 3-kinase

2.7.1.65 scyllo-inosamine 4-kinase

2.7.1.66 undecaprenol kinase

2.7.1.67 1-phosphatidylinositol 4-kinase

2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase

2.7.1.69 protein-N^π-phosphohistidine—sugar phosphotransferase

2.7.1.70 created 1972, deleted 2004

2.7.1.71 shikimate kinase

2.7.1.72 streptomycin 6-kinase

2.7.1.73 inosine kinase

2.7.1.74 deoxycytidine kinase

2.7.1.75 created 1972, deleted 1976

2.7.1.76 2′-deoxyadenosine kinase

2.7.1.77 nucleoside phosphotransferase

2.7.1.78 polynucleotide 5′-hydroxyl-kinase

2.7.1.79 diphosphate—glycerol phosphotransferase

2.7.1.80 diphosphate—serine phosphotransferase

2.7.1.81 hydroxylysine kinase

2.7.1.82 ethanolamine kinase

2.7.1.83 pseudouridine kinase

2.7.1.84 alkylglycerone kinase

2.7.1.85 β-glucoside kinase

2.7.1.86 NADH kinase

2.7.1.87 streptomycin 3′′-kinase

2.7.1.88 dihydrostreptomycin-6-phosphate 3′α-kinase

2.7.1.89 thiamine kinase

2.7.1.90 diphosphate—fructose-6-phosphate 1-phosphotransferase

2.7.1.91 sphingosine kinase

2.7.1.92 5-dehydro-2-deoxygluconokinase

2.7.1.93 alkylglycerol kinase

2.7.1.94 acylglycerol kinase

2.7.1.95 kanamycin kinase

2.7.1.96 created 1978, deleted 1978

2.7.1.97 created 1978, deleted 1992

2.7.1.98 created 1978, deleted 1984

2.7.1.99 [pyruvate dehydrogenase (acetyl-transferring)] kinase

2.7.1.100 S-methyl-5-thioribose kinase

2.7.1.101 tagatose kinase

2.7.1.102 hamamelose kinase

2.7.1.103 viomycin kinase

2.7.1.104 diphosphate—protein phosphotransferase

2.7.1.105 6-phosphofructo-2-kinase

2.7.1.106 glucose-1,6-bisphosphate synthase

2.7.1.107 diacylglycerol kinase (ATP)

2.7.1.108 dolichol kinase

2.7.1.109 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

2.7.1.110 dephospho-[reductase kinase] kinase

2.7.1.111 created 1984, deleted 1992

2.7.1.112 protein-tyrosine kinase

2.7.1.113 deoxyguanosine kinase

2.7.1.114 AMP—thymidine kinase

2.7.1.115 [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] kinase

2.7.1.116 [isocitrate dehydrogenase (NADP⁺)] kinase

2.7.1.117 myosin-light-chain kinase

2.7.1.118 ADP—thymidine kinase

2.7.1.119 hygromycin-B 7′′-O-kinase

2.7.1.120 caldesmon kinase

2.7.1.121 phosphoenolpyruvate—glycerone phosphotransferase

2.7.1.122 xylitol kinase

2.7.1.123 Ca²⁺/calmodulin-dependent protein kinase

2.7.1.124 [tyrosine 3-monooxygenase] kinase

2.7.1.125 rhodopsin kinase

2.7.1.126 [β-adrenergic-receptor] kinase

2.7.1.127 inositol-trisphosphate 3-kinase

2.7.1.128 [acetyl-CoA carboxylase] kinase

2.7.1.129 [myosin-heavy-chain] kinase

2.7.1.130 tetraacyldisaccharide 4′-kinase

2.7.1.131 [low-density-lipoprotein] kinase

2.7.1.132 tropomyosin kinase

2.7.1.133 created 1990, deleted 2002

2.7.1.134 inositol-tetrakisphosphate 1-kinase

2.7.1.135 [tau-protein] kinase

2.7.1.136 macrolide 2′-kinase

2.7.1.137 phosphatidylinositol 3-kinase

2.7.1.138 ceramide kinase

2.7.1.139 created 1992, deleted 2002

2.7.1.140 inositol-tetrakisphosphate 5-kinase

2.7.1.141 [RNA-polymerase]-subunit kinase

2.7.1.142 glycerol-3-phosphate—glucose phosphotransferase

2.7.1.143 diphosphate-purine nucleoside kinase

2.7.1.144 tagatose-6-phosphate kinase

2.7.1.145 deoxynucleoside kinase

2.7.1.146 ADP-specific phosphofructokinase

2.7.1.147 ADP-specific glucose/glucosamine kinase

2.7.1.148 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase

2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase

2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase

2.7.1.151 inositol-polyphosphate multikinase

2.7.1.152 created 2002, deleted 2003

2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase

2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase

2.7.1.155 diphosphoinositol-pentakisphosphate kinase

2.7.1.156 adenosylcobinamide kinase

2.7.1.157 N-acetylgalactosamine kinase

2.7.1.158 inositol-pentakisphosphate 2-kinase

2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase

2.7.1.160 2′-phosphotransferase

2.7.1.161 CTP-dependent riboflavin kinase

2.7.1.162 N-acetylhexosamine 1-kinase

2.7.1.163 hygromycin B 4-O-kinase

2.7.1.164 O-phosphoseryl-tRNA^Sec kinase

2.7.1.165 glycerate 2-kinase

2.7.1.166 3-deoxy-D-manno-octulosonic acid kinase

2.7.1.167 D-glycero-β-D-manno-heptose-7-phosphate kinase

2.7.1.168 D-glycero-α-D-manno-heptose-7-phosphate kinase

2.7.1.169 pantoate kinase

2.7.1.170 anhydro-N-acetylmuramic acid kinase

2.7.1.171 protein-fructosamine 3-kinase

2.7.1.172 protein-ribulosamine 3-kinase

2.7.1.173 nicotinate riboside kinase

2.7.1.174 diacylglycerol kinase (CTP)

2.7.1.175 maltokinase

2.7.1.176 UDP-N-acetylglucosamine kinase

2.7.1.177 L-threonine kinase

2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase

2.7.1.179 kanosamine kinase

2.7.1.180 FAD:protein FMN transferase

2.7.1.181 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase

2.7.1.182 phytol kinase

2.7.1.183 glycoprotein-mannosyl O⁶-kinase

2.7.1.184 sulfofructose kinase

2.7.1.185 mevalonate 3-kinase

2.7.1.186 mevalonate-3-phosphate 5-kinase

2.7.1.187 acarbose 7^IV-phosphotransferase

2.7.1.188 2-epi-5-epi-valiolone 7-kinase

2.7.1.189 autoinducer-2 kinase

2.7.1.190 aminoglycoside 2′′-phosphotransferase

2.7.1.191 protein-N^π-phosphohistidine—D-mannose phosphotransferase

2.7.1.192 protein-N^π-phosphohistidine—N-acetylmuramate phosphotransferase

2.7.1.193 protein-N^π-phosphohistidine—N-acetyl-D-glucosamine phosphotransferase

2.7.1.194 protein-N^π-phosphohistidine—L-ascorbate phosphotransferase

2.7.1.195 protein-N^π-phosphohistidine—2-O-α-mannosyl-D-glycerate phosphotransferase

2.7.1.196 protein-N^π-phosphohistidine—N,N′-diacetylchitobiose phosphotransferase

2.7.1.197 protein-N^π-phosphohistidine—D-mannitol phosphotransferase

2.7.1.198 protein-N^π-phosphohistidine—D-sorbitol phosphotransferase

2.7.1.199 protein-N^π-phosphohistidine—D-glucose phosphotransferase

2.7.1.200 protein-N^π-phosphohistidine—galactitol phosphotransferase

2.7.1.201 protein-N^π-phosphohistidine—trehalose phosphotransferase

2.7.1.202 protein-N^π-phosphohistidine—D-fructose phosphotransferase

2.7.1.203 protein-N^π-phosphohistidine—D-glucosaminate phosphotransferase

2.7.1.204 protein-N^π-phosphohistidine—D-galactose phosphotransferase

2.7.1.205 protein-N^π-phosphohistidine—cellobiose phosphotransferase

2.7.1.206 protein-N^π-phosphohistidine—L-sorbose phosphotransferase

2.7.1.207 protein-N^π-phosphohistidine—lactose phosphotransferase

2.7.1.208 protein-N^π-phosphohistidine—maltose phosphotransferase

2.7.1.209 L-erythrulose 1-kinase

2.7.1.210 D-erythrulose 4-kinase

2.7.1.211 protein-N^π-phosphohistidine—sucrose phosphotransferase

2.7.1.212 α-D-ribose-1-phosphate 5-kinase (ADP)

2.7.1.213 cytidine kinase

2.7.1.214 C₇-cyclitol 7-kinase

2.7.1.215 erythritol kinase (D-erythritol 1-phosphate-forming)

2.7.1.216 farnesol kinase

2.7.1.217 3-dehydrotetronate 4-kinase

2.7.1.218 fructoselysine 6-kinase

2.7.1.219 D-threonate 4-kinase

2.7.1.220 D-erythronate 4-kinase

2.7.1.221 N-acetylmuramate 1-kinase

2.7.1.222 4-hydroxytryptamine kinase

2.7.1.223 aminoimidazole riboside kinase

2.7.1.224 cytidine diphosphoramidate kinase

2.7.1.225 L-serine kinase (ATP)

2.7.1.226 L-serine kinase (ADP)

2.7.1.227 inositol phosphorylceramide synthase

2.7.1.228 mannosyl-inositol-phosphoceramide inositolphosphotransferase

2.7.1.229 deoxyribokinase

2.7.1.230 amicoumacin kinase

2.7.1.231 3-oxoisoapionate kinase

2.7.1.232 levoglucosan kinase

2.7.1.233 apulose kinase

2.7.1.234 D-tagatose-1-phosphate kinase

2.7.1.235 lipopolysaccharide core heptose(I) kinase

2.7.1.236 NAD⁺ 3′-kinase

2.7.1.237 GTP-dependent dephospho-CoA kinase

2.7.1.238 phenol phosphorylase

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)