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EC 2.7.11.22 Details
EC number
2.7.11.22
Accepted name
cyclin-dependent kinase
Reaction
ATP + a protein = ADP + a phosphoprotein
Other name(s)
Bur1,
Bur1 Cdk,
Cak1,
Cak1p,
cdc2,
cdc2 kinase,
Cdc28p,
CDK,
cdk-activating kinase,
Cdk-activating protein kinase,
cdk1,
cdk2,
Cdk2,
cdk3,
cdk4,
cdk5,
cdk6,
cdk7,
cdk8,
cdk9,
cyclin A-activated cdc2,
cyclin A-activated cdk2,
cyclin D-cdk6 kinase,
cyclin D-dependent kinase,
cyclin E kinase,
cyclin-A associated kinase,
cyclin-dependent kinase 6,
cyclin-dependent kinase-2,
cyclin-dependent kinase-4,
cyclin-dependent protein kinase activating kinase,
cyk,
D-type cyclin kinase,
nclk,
neuronal cdc2-like kinase,
PCTAIRE-1,
STK25
Systematic name
ATP:cyclin phosphotransferase
Comment
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
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