EC Explorer

[browse EC tree] - [search]

EC 2.7.11.15 Details

show Brenda entry

EC number

2.7.11.15

Accepted name

β-adrenergic-receptor kinase

Reaction

ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor]

Other name(s)

ATP:β-adrenergic-receptor phosphotransferase, [β-adrenergic-receptor] kinase, β-adrenergic receptor-specific kinase, β-AR kinase, β-ARK, β-ARK 1, β-ARK 2, β-receptor kinase, GRK2, GRK3, β-adrenergic-receptor kinase (phosphorylating), β2ARK, βARK1, β-adrenoceptor kinase, β-adrenoceptor kinase 1, β-adrenoceptor kinase 2, ADRBK1, BARK1, adrenergic receptor kinase, STK15

Systematic name

ATP:[β-adrenergic receptor] phosphotransferase

CAS registry number

102925-39-3

Comment

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn²⁺ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).

History

created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.11.1 non-specific serine/threonine protein kinase

2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase

2.7.11.3 dephospho-[reductase kinase] kinase

2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

2.7.11.5 [isocitrate dehydrogenase (NADP⁺)] kinase

2.7.11.6 [tyrosine 3-monooxygenase] kinase

2.7.11.7 myosin-heavy-chain kinase

2.7.11.8 Fas-activated serine/threonine kinase

2.7.11.9 Goodpasture-antigen-binding protein kinase

2.7.11.10 IκB kinase

2.7.11.11 cAMP-dependent protein kinase

2.7.11.12 cGMP-dependent protein kinase

2.7.11.13 protein kinase C

2.7.11.14 rhodopsin kinase

2.7.11.15 β-adrenergic-receptor kinase

2.7.11.16 G-protein-coupled receptor kinase

2.7.11.17 Ca²⁺/calmodulin-dependent protein kinase

2.7.11.18 myosin-light-chain kinase

2.7.11.19 phosphorylase kinase

2.7.11.20 elongation factor 2 kinase

2.7.11.21 polo kinase

2.7.11.22 cyclin-dependent kinase

2.7.11.23 [RNA-polymerase]-subunit kinase

2.7.11.24 mitogen-activated protein kinase

2.7.11.25 mitogen-activated protein kinase kinase kinase

2.7.11.26 tau-protein kinase

2.7.11.27 [acetyl-CoA carboxylase] kinase

2.7.11.28 tropomyosin kinase

2.7.11.29 low-density-lipoprotein receptor kinase

2.7.11.30 receptor protein serine/threonine kinase

2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

2.7.11.32 [pyruvate, phosphate dikinase] kinase

2.7.11.33 [pyruvate, water dikinase] kinase

2.7.11.34 NEK6-subfamily protein kinase

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)