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EC 2.7.11.19 Details
EC number
2.7.11.19
Accepted name
phosphorylase kinase
Reaction
2 ATP + phosphorylase b = 2 ADP + phosphorylase a
Other name(s)
dephosphophosphorylase kinase,
glycogen phosphorylase kinase,
PHK,
phosphorylase b kinase,
phosphorylase B kinase,
phosphorylase kinase (phosphorylating),
STK17
Systematic name
ATP:phosphorylase-b phosphotransferase
CAS registry number
9001-88-1
Comment
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis—glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The γ subunit of the tetrameric enzyme is the catalytic subunit.
History
created 1961 as EC 2.7.1.38, transferred 2005 to EC 2.7.11.19
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