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EC 2.7.10.1 Details

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EC number

2.7.10.1

Accepted name

receptor protein-tyrosine kinase

Reaction

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Other name(s)

AATK, AATYK, AATYK2, AATYK3, ACH, ALK, anaplastic lymphoma kinase, ARK, ATP:protein-tyrosine O-phosphotransferase (ambiguous), AXL, Bek, Bfgfr, BRT, Bsk, C-FMS, CAK, CCK4, CD115, CD135, CDw135, Cek1, Cek10, Cek11, Cek2, Cek3, Cek5, Cek6, Cek7, CFD1, CKIT, CSF1R, DAlk, DDR1, DDR2, Dek, DKFZp434C1418, Drosophila Eph kinase, DRT, DTK, Ebk, ECK, EDDR1, Eek, EGFR, Ehk2, Ehk3, Elk, EPH, EPHA1, EPHA2, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EphB5, ephrin-B3 receptor tyrosine kinase, EPHT, EPHT2, EPHT3, EPHX, ERBB, ERBB1, ERBB2, ERBB3, ERBB4, ERK, Eyk, FGFR1, FGFR2, FGFR3, FGFR4, FLG, FLK1, FLK2, FLT1, FLT2, FLT3, FLT4, FMS, Fv2, HBGFR, HEK11, HEK2, HEK3, HEK5, HEK6, HEP, HER2, HER3, HER4, HGFR, HSCR1, HTK, IGF1R, INSR, INSRR, insulin receptor protein-tyrosine kinase, IR, IRR, JTK12, JTK13, JTK14, JWS, K-SAM, KDR, KGFR, KIA0641, KIAA1079, KIAA1459, Kil, Kin15, Kin16, KIT, KLG, LTK, MCF3, Mdk1, Mdk2, Mdk5, MEhk1, MEN2A/B, Mep, MER, MERTK, MET, Mlk1, Mlk2, Mrk, MST1R, MTC1, MUSK, Myk1, N-SAM, NEP, NET, Neu, neurite outgrowth regulating kinase, NGL, NOK, nork, novel oncogene with kinase-domain, Nsk2, NTRK1, NTRK2, NTRK3, NTRK4, NTRKR1, NTRKR2, NTRKR3, Nuk, NYK, PCL, PDGFR, PDGFRA, PDGFRB, PHB6, protein-tyrosine kinase (ambiguous), protein tyrosine kinase (ambiguous), PTK, PTK3, PTK7, receptor protein tyrosine kinase, RET, RON, ROR1, ROR2, ROS1, RSE, RTK, RYK, SEA, Sek2, Sek3, Sek4, Sfr, SKY, STK (ambiguous), STK1, TEK, TIE, TIE1, TIE2, TIF, TKT, TRK, TRKA, TRKB, TRKC, TRKE, TYK1, TYRO10, Tyro11, TYRO3, Tyro5, Tyro6, TYRO7, UFO, VEGFR1, VEGFR2, VEGFR3, Vik, YK1, Yrk

Systematic name

ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)

Comment

The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.

History

created 1984 as EC 2.7.1.112, part transferred 2005 to EC 2.7.10.1

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.4 With a disulfide as acceptor

1.2.5 With a quinone or similar compound as acceptor

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.18.1 With NAD⁺ or NADP⁺ as acceptor

1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

1.18.3 With H⁺ as acceptor (deleted sub-subclass)

1.18.6 With dinitrogen as acceptor

1.18.96 With other, known, acceptors (deleted sub-subclass)

1.18.99 With H⁺ as acceptor (deleted sub-subclass)

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.10.1 receptor protein-tyrosine kinase

2.7.10.2 non-specific protein-tyrosine kinase

2.7.10.3 bacterial tyrosine kinase

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)