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A-type platelet-derived growth factor receptor
-
ALK receptor tyrosine kinase
-
-
ALK tyrosine kinase receptor
alpha platelet-derived growth factor receptor
Anaplastic lymphoma kinase
basic fibroblast growth factor receptor 1
BDNF/NT-3 growth factors receptor
beta platelet-derived growth factor receptor
Brain-specific kinase
-
-
-
c-Kit receptor protein-tyrosine kinase
-
c-Kit receptor tyrosine kinase
c-Kit tyrosine kinase
-
-
-
c-Met receptor tyrosine kinase
Cell adhesion kinase
-
-
-
chicken embryo kinase 5
-
class II receptor tyrosine kinase
-
colony-stimulating factor-1 receptor
-
-
CSF-1 receptor
-
also known as c-fms and CD115
discoidin domain receptor 1
-
discoidin domain receptor 2
discoidin domain receptor tyrosine kinase 1
-
Discoidin receptor tyrosine kinase
Drosophila relative of ERBB
-
-
-
DTK receptor tyrosine kinase
-
EGF receptor protein-tyrosine kinase
-
-
EGF receptor tyrosine kinase
EGFR protein tyrosine kinase
Egg laying defective protein 15
-
-
-
Embryonic brain kinase
-
-
-
embryonic receptor kinase
-
Endothelial kinase receptor EK1
-
-
-
Eph homologous kinase 3
-
Eph receptor tyrosine kinase
-
EPH-and ELK-related kinase
-
-
-
Eph-related receptor tyrosine kinase Cek9
-
EPHA1 receptor tyrosine kinase
-
ephrin type-A receptor 1
-
ephrin type-A receptor 4A
-
ephrin type-A receptor 4B
-
ephrin type-A receptor 6
-
ephrin type-B receptor 1A
-
ephrin type-B receptor 5
-
epidermal growth factor receptor
epidermal growth factor receptor 2
-
-
epidermal growth factor receptor 4
-
epidermal growth factor receptor kinase
-
-
epidermal growth factor receptor tyrosine kinase
epidermal growth factor receptor tyrosine kinase inhibitor
-
-
Epidermal growth factor receptor-related protein
-
-
-
epidermal growth factor type II receptor
-
-
epidermal growth factor tyrosine protein kinase
-
-
epidermal growth factor-receptor
-
-
epidermal growth-factor receptor tyrosine kinase
-
-
epithelial discoidin domain receptor 1
ErbB receptor protein-tyrosine kinase
-
-
erbB tyrosine kinase
-
-
-
ErbB1 tyrosine kinase
-
-
erbB2 receptor tyrosine kinase
ErbB2 tyrosine kinase
-
-
ErbB3 receptor tyrosine kinase
-
erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2
-
-
erythropoietin-producing human hepatocellular carcinoma B3
-
FGF receptor tyrosine kinase
-
-
fibroblast growth factor receptor
fibroblast growth factor receptor 1
fibroblast growth factor receptor 2
fibroblast growth factor receptor 3
fibroblast growth factor receptor 4
fibroblast growth factor receptor BFR-2
-
fibroblast growth factor receptor homolog 1
-
fibroblast growth factor receptor homolog 2
-
FLT3 receptor protein
-
-
FLT3/FLK2 receptor tyrosine kinase
-
FLT4 receptor tyrosine kinase
-
fms-like tyrosine kinase 3
-
-
GP145-TrkB/GP95-TrkB
-
-
-
growth hormone receptor
-
-
Heparin-binding growth factor receptor
-
-
-
hepatocyte growth factor receptor
HER receptor protein-tyrosine kinase
-
-
high affinity nerve growth factor receptor
human epidermal growth factor receptor2
-
-
hydroxyaryl-protein kinase
-
-
-
IGF-1R tyrosine kinase
-
-
insulin receptor protein tyrosine kinase
-
-
insulin receptor protein-tyrosine kinase
-
-
-
insulin receptor tyrosine kinase
insulin receptor-beta subunit
-
-
insulin receptor-related protein
insulin receptor-related receptor
-
insulin-growth factor-1 receptor
-
-
insulin-like growth factor 1 receptor
-
insulin-like growth factor I receptor
insulin-like growth factor receptor
-
-
insulin-like growth factor type I receptor
Insulin-like growth factor-1 receptor
-
-
insulin-like growth factor-1 receptor kinase
-
-
Insulin-like Growth Factor-1 receptor tyrosine kinase
-
-
insulin-like peptide receptor
-
insulin-receptor tyrosine kinase
-
-
IR-related receptor
-
-
-
IRR-protein tyrosine kinase
-
KDR/fetal liver kinase-1
-
-
Keratinocyte growth factor receptor
Kinase insert domain receptor
-
-
-
Kit protein-tyrosine kinase
KIT receptor tyrosine kinase
-
-
Let-23 receptor protein-tyrosine kinase
-
leukocyte tyrosine kinase receptor
ltk receptor tyrosine kinase
-
macrophage colony stimulating factor I receptor
macrophage colony-stimulating factor receptor
macrophage stimulating 1 receptor
-
-
macrophage stimulating 1-receptor
-
-
macrophage-colony stimulating factor receptor
-
-
macrophage-stimulating protein receptor
mast/stem cell growth factor receptor
melanoma receptor protein-tyrosine kinase
-
Mer receptor tyrosine kinase
-
Met proto-oncogene tyrosine kinase
-
-
-
Met receptor-tyrosine kinase
Met/hepatocyte growth factor receptor tyrosine kinase
-
mouse developmental kinase 1
-
muscle-specific receptor tyrosine kinase
muscle-specific receptor-tyrosine kinase
-
-
myoblast growth factor receptor egl-15
-
nerve growth factor receptor
-
-
neuregulin receptor ErbB-4
-
Neurospecific receptor tyrosine kinase
-
-
-
neurotrophin tyrosine receptor kinase
non-receptor protein tyrosine kinase
-
-
NT-3 growth factor receptor
nuclear growth factor tyrosine protein kinase
-
-
orphan receptor tyrosine kinase
-
-
p75 neurotrophin receptor
-
-
PDGF receptor tyrosine kinase
platelet derived growth factor receptor-beta
-
platelet-derived growth factor receptor
platelet-derived growth factor receptor alpha
platelet-derived growth factor receptor kinase
-
-
platelet-derived growth factor receptor-beta
-
-
platelet-derived growth factor RPTK
-
-
proline-rich tyrosinekinase
-
-
protein kinase Cdelta
-
-
protein receptor tyrosine kinase RTK 6
-
Protein-tyrosine kinase byk
-
-
-
protein-tyrosine kinase ITK/EMT
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
proto-oncogene tyrosine-protein kinase MER
proto-oncogene tyrosine-protein kinase receptor ret
proto-oncogene tyrosine-protein kinase ROS
-
rceptor protein-tyrosine kinase erbB-4
-
recepteur d'origine nantais
recepteur d'origine nantais receptor tyrosine kinase
Recepteur d’Origine Nantais
-
receptor for macrophage colony-stimulating factor
-
-
receptor for stem cell factor
-
-
receptor protein tyrosine kinase
-
-
receptor protein tyrosine kinase RTK
-
receptor protein-tyrosine kinase erbB-2
receptor protein-tyrosine kinase erbB-3
receptor protein-tyrosine kinase erbB-4
-
Receptor protein-tyrosine kinase HEK11
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
receptor tyrosine kinase c-Kit
receptor tyrosine kinase Cek8
-
receptor tyrosine kinase EphA1
-
-
receptor tyrosine kinase EphA2
Receptor tyrosine kinase MerTK
-
-
-
receptor tyrosine kinase RET
receptor tyrosine kinase RON
-
-
receptor tyrosine kinase ROR1
-
receptor tyrosine kinase Ror2
receptor tyrosine kinase Sek
-
receptor tyrosine kinase Sky
-
receptor tyrosine kinase vascular endothelial growth factor receptor-2
-
-
receptor tyrosine-protein kinase erbB-2
-
Receptor-activated Janus kinase
-
-
-
receptor-like protein tyrosine kinase bsk
-
receptor-like protein-tyrosine kinase TK14
-
receptor-like tyrosine-protein kinase kin-15
-
receptor-like tyrosine-protein kinase kin-16
-
receptor-type tyrosine kinase termed Rse
-
receptor-type tyrosine-protein kinase FLT3
-
Ret receptor tyrosine kinase
RON receptor tyrosine kinase
Ron tyrosine kinase receptor
-
Ron/Stk receptor tyrosine kinase
-
Sek-1 receptor tyrosine kinase
-
sevenless receptor tyrosine kinase
-
-
sky receptor tyrosine kinase
-
Slow nerve growth factor receptor
-
-
-
soluble fms-like tyrosine kinase 1
-
-
sponge receptor tyrosine kinase
-
stem cell derived tyrosine kinase
-
-
stem cell factor receptor
-
-
stem cell tyrosine kinase 1
-
Stem cell-derived tyrosine kinase
subclass III receptor tyrosine kinase
-
-
Tec family kinase EMT/ITK/TSK
-
Tek receptor tyrosine kinase
-
TRK1 transforming tyrosine kinase protein
-
-
-
TrkB tyrosine kinase
-
-
-
TrkC receptor tyrosine kinases
-
TrkC tyrosine kinase
-
-
-
Tunica interna endothelial cell kinase
-
-
-
Tyro 10 receptor tyrosine kinase
-
Tyrosine kinase CEK6 receptor
-
-
-
Tyrosine kinase DDR
-
-
-
tyrosine kinase domain of the insulin receptor
-
-
tyrosine kinase Emt/Itk
-
tyrosine kinase receptor
-
-
tyrosine kinase receptor CEK2
-
tyrosine kinase receptor CEK3
-
Tyrosine kinase receptor HD-14
-
-
-
tyrosine kinase receptor HER2
-
tyrosine kinase receptor RON
-
-
tyrosine kinase receptor trkE
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
Tyrosine-protein kinase CAK
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
tyrosine-protein kinase Dnt
-
tyrosine-protein kinase Drl
-
Tyrosine-protein kinase DTK
-
-
-
tyrosine-protein kinase Etk
Tyrosine-protein kinase FLT3
-
-
-
Tyrosine-protein kinase FRT
-
-
-
tyrosine-protein kinase ITK/TSK
-
tyrosine-protein kinase Ptk
-
Tyrosine-protein kinase receptor CEK10
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
tyrosine-protein kinase receptor Tie-1
tyrosine-protein kinase receptor torso
-
tyrosine-protein kinase receptor TYRO3
tyrosine-protein kinase receptor UFO
Tyrosine-protein kinase receptor XEK
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
Tyrosine-protein kinase RSE
-
-
-
tyrosine-protein kinase RYK
Tyrosine-protein kinase SKY
-
-
-
tyrosine-protein kinase transforming protein erbB
tyrosine-protein kinase transforming protein kit
tyrosine-protein kinase transforming protein RYK
-
tyrosine-protein kinase transmembrane receptor Ror
-
tyrosine-protein kinase transmembrane receptor ROR1
tyrosine-protein kinase transmembrane receptor ROR2
tyrosine-protein kinase Wzc
VAB-1 Eph receptor tyrosine kinase
-
vascular endothelial growth factor
-
-
vascular endothelial growth factor 2
-
-
vascular endothelial growth factor receptor
vascular endothelial growth factor receptor 1
vascular endothelial growth factor receptor 2
vascular endothelial growth factor receptor 3
vascular endothelial growth factor receptor tyrosine kinase
-
-
vascular endothelial growth factor receptor-1
-
vascular endothelial growth-factor receptor-1 tyrosine kinase
-
-
Vascular permeability factor receptor
-
-
-
VEGF factor receptor tyrosine kinase
-
-
VEGF receptor tyrosine kinase
VEGFR tyrosine kinase
-
-
VEGFR-1 tyrosine kinase
-
-
VEGFR-2 tyrosine kinase
-
VEGFR2/kinase domain region
-
-
Xenopus Elk-like kinase
-
Adhesion-related kinase

-
-
-
Adhesion-related kinase
-
ALK

-
-
ALK tyrosine kinase receptor

-
ALK tyrosine kinase receptor
-
alpha platelet-derived growth factor receptor

-
alpha platelet-derived growth factor receptor
-
alpha platelet-derived growth factor receptor
-
alpha platelet-derived growth factor receptor
-
Anaplastic lymphoma kinase

-
-
-
Anaplastic lymphoma kinase
-
-
Anaplastic lymphoma kinase
-
-
Anaplastic lymphoma kinase
-
-
angiopoietin 1 receptor

-
angiopoietin 1 receptor
-
angiopoietin 1 receptor
-
angiopoietin 1 receptor
-
Axl

-
-
basic fibroblast growth factor receptor 1

-
basic fibroblast growth factor receptor 1
-
490167, 490218, 490219, 490220, 490221, 490222, 490223, 490225, 490226, 490227, 490228, 490229, 490230, 490231
basic fibroblast growth factor receptor 1
-
basic fibroblast growth factor receptor 1
-
BDNF/NT-3 growth factors receptor

-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
BDNF/NT-3 growth factors receptor
-
beta platelet-derived growth factor receptor

-
beta platelet-derived growth factor receptor
-
c-fms

-
-
-
c-kit

-
-
-
c-Kit receptor tyrosine kinase

-
-
c-Kit receptor tyrosine kinase
-
-
C-mer

-
-
-
c-met

-
-
-
c-Met receptor tyrosine kinase

-
-
c-Met receptor tyrosine kinase
-
discoidin domain receptor 2

-
discoidin domain receptor 2
-
Discoidin receptor tyrosine kinase

-
-
-
Discoidin receptor tyrosine kinase
-
DTK

-
-
EBK

-
-
-
EGF receptor

-
EGF receptor tyrosine kinase

-
-
-
EGF receptor tyrosine kinase
-
-
EGF receptor tyrosine kinase
-
-
EGF receptor tyrosine kinase
-
-
EGF-R

-
-
Egfr

-
-
-
Egfr
-
-
660727, 660873, 661457, 662678, 672910, 672957, 674681, 676837, 677234, 691067, 693346, 693727, 694498, 703259, 704651, 705802, 737815, 737831, 737992, 738710, 738744
EGFR protein tyrosine kinase

-
-
EGFR protein tyrosine kinase
-
-
EGFR protein tyrosine kinase
-
-
EGFR tyrosine kinase

-
-
EphA1

-
-
EphA2

-
-
ephrin type-A receptor 2

-
ephrin type-A receptor 2
-
ephrin type-A receptor 3

-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 3
-
ephrin type-A receptor 4

-
ephrin type-A receptor 4
-
ephrin type-A receptor 4
-
ephrin type-A receptor 5

-
ephrin type-A receptor 5
-
ephrin type-A receptor 5
-
ephrin type-A receptor 5
-
ephrin type-A receptor 7

-
ephrin type-A receptor 7
-
ephrin type-A receptor 7
-
ephrin type-A receptor 7
-
ephrin type-A receptor 8

-
ephrin type-A receptor 8
-
ephrin type-B receptor 1

-
ephrin type-B receptor 1
-
ephrin type-B receptor 2

-
ephrin type-B receptor 2
-
ephrin type-B receptor 2
-
ephrin type-B receptor 3

-
ephrin type-B receptor 3
-
ephrin type-B receptor 4

-
ephrin type-B receptor 4
-
epidermal growth factor receptor

-
-
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor
-
-
660727, 660873, 661457, 661551, 662556, 662679, 674681, 677234, 691067, 691636, 693727, 694498, 702950, 703259, 704651, 705802, 737815
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor tyrosine kinase

-
-
epidermal growth factor receptor tyrosine kinase
-
epidermal growth factor receptor tyrosine kinase
-
-
Epithelial cell kinase

-
-
-
epithelial discoidin domain receptor 1

-
epithelial discoidin domain receptor 1
-
epithelial discoidin domain receptor 1
-
ErbB-2

-
ErbB-4 tyrosine kinase

-
-
ErbB-4 tyrosine kinase
-
-
ERBB1

-
-
ErbB2

-
-
erbB2 receptor tyrosine kinase

-
-
erbB2 receptor tyrosine kinase
-
erbB2 receptor tyrosine kinase
-
-
erbB2 receptor tyrosine kinase
-
-
ERK

-
-
-
FGFR

-
-
FGFR2

-
-
FGFR3

-
-
FGFR4

-
-
fibroblast growth factor receptor

-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor 1

-
fibroblast growth factor receptor 1
-
fibroblast growth factor receptor 2

-
490218, 490288, 490289, 490290, 490291, 490292, 490293, 490294, 490295, 490296, 490297, 490298, 490299, 490300, 490301, 490302, 490303, 490304, 490305, 490306
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 3

-
490320, 490323, 490324, 490325, 490326, 490327, 490328, 490329, 490330, 490331, 490332, 490333, 490335, 490336, 490337, 490338, 490339, 721711
fibroblast growth factor receptor 3
-
fibroblast growth factor receptor 4

-
fibroblast growth factor receptor 4
-
fibroblast growth factor receptor 4
-
FL cytokine receptor

-
Flk-1

-
FLT3

-
-
GCTK

-
-
-
HEK

-
-
-
hepatocyte growth factor receptor

-
hepatocyte growth factor receptor
-
-
hepatocyte growth factor receptor
-
hepatocyte growth factor receptor
-
-
hepatocyte growth factor receptor
-
hepatocyte growth factor receptor
-
HER2

-
-
high affinity nerve growth factor receptor

-
high affinity nerve growth factor receptor
-
HYK

-
-
-
IGF-1R

-
-
IGF-IR

-
-
ILP receptor

-
-
-
insulin receptor

-
-
insulin receptor kinase

-
-
insulin receptor kinase
-
-
insulin receptor kinase
-
-
insulin receptor tyrosine kinase

-
-
insulin receptor tyrosine kinase
-
-
insulin receptor-related protein

-
insulin receptor-related protein
-
insulin receptor-related protein
-
insulin-like growth factor I receptor

-
insulin-like growth factor I receptor
-
insulin-like growth factor I receptor
-
insulin-like growth factor type I receptor

-
-
insulin-like growth factor type I receptor
-
-
insulin-like receptor

-
IRK

-
-
-
IRR

-
-
-
KDR

-
Keratinocyte growth factor receptor

-
-
-
Keratinocyte growth factor receptor
-
-
Keratinocyte growth factor receptor
-
KGF receptor

-
-
KIT

-
Kit protein-tyrosine kinase

-
-
Kit protein-tyrosine kinase
-
-
leukocyte tyrosine kinase receptor

-
leukocyte tyrosine kinase receptor
-
macrophage colony stimulating factor I receptor

-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
macrophage colony-stimulating factor receptor

-
-
macrophage colony-stimulating factor receptor
-
macrophage-stimulating protein receptor

-
macrophage-stimulating protein receptor
-
mast/stem cell growth factor receptor

-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
mast/stem cell growth factor receptor
-
MET

-
-
Met receptor-tyrosine kinase

-
-
Met receptor-tyrosine kinase
-
-
Met RTK

-
-
muscle-specific receptor tyrosine kinase

-
-
muscle-specific receptor tyrosine kinase
-
-
muscle-specific receptor tyrosine kinase
-
MuSK

-
-
NET

-
-
-
neurotrophin tyrosine receptor kinase

-
-
neurotrophin tyrosine receptor kinase
-
NT-3 growth factor receptor

-
NT-3 growth factor receptor
-
NT-3 growth factor receptor
-
NT-3 growth factor receptor
-
PDGF receptor

-
-
PDGF receptor tyrosine kinase

-
-
PDGF receptor tyrosine kinase
-
-
PDGF receptor tyrosine kinase
-
-
PDGFR

-
-
PDGFR-alpha

-
-
PDGFR-beta

-
-
PDGFRbeta

-
-
platelet-derived growth factor receptor

-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor
-
-
platelet-derived growth factor receptor alpha

-
-
platelet-derived growth factor receptor alpha
-
Protein tyrosine kinase

-
-
Protein tyrosine kinase
-
-
proto-oncogene tyrosine-protein kinase MER

-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase receptor ret

-
proto-oncogene tyrosine-protein kinase receptor ret
-
PTK

-
-
recepteur d'origine nantais

-
-
recepteur d'origine nantais
-
recepteur d'origine nantais receptor tyrosine kinase

-
-
recepteur d'origine nantais receptor tyrosine kinase
-
-
receptor protein-tyrosine kinase erbB-2

-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-2
-
receptor protein-tyrosine kinase erbB-3

-
receptor protein-tyrosine kinase erbB-3
-
receptor tyrosine kinase

-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
-
660727, 661669, 662678, 662679, 662856, 672173, 672948, 673212, 673570, 674071, 690295, 690447, 691595, 691636, 692230, 693346, 693727, 737744
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase
-
receptor tyrosine kinase c-Kit

-
receptor tyrosine kinase c-Kit
-
receptor tyrosine kinase c-Kit
-
receptor tyrosine kinase EphA2

-
receptor tyrosine kinase EphA2
-
receptor tyrosine kinase RET

-
-
receptor tyrosine kinase RET
-
-
receptor tyrosine kinase Ror2

-
receptor tyrosine kinase Ror2
-
-
Ret receptor tyrosine kinase

-
-
Ret receptor tyrosine kinase
-
-
Ron

-
-
RON receptor tyrosine kinase

-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RON receptor tyrosine kinase
-
-
RPTK

-
-
RTK

-
-
-
RTK
-
-
661669, 662856, 672173, 672948, 673212, 692230, 693346, 693727, 737744, 737815, 737818, 737823, 738414, 738624, 738744, 739054, 739206
RTKs

-
sevenless protein

-
Stem cell-derived tyrosine kinase

-
-
-
Stem cell-derived tyrosine kinase
-
-
STK

-
-
Tie1

-
-
Tie2

-
TrkA

-
-
trkB

-
-
TrkB receptor

-
-
TrkC

-
-
tyrosine-protein kinase Etk

-
tyrosine-protein kinase Etk
-
tyrosine-protein kinase Etk
-
tyrosine-protein kinase receptor Tie-1

-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor TYRO3

-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor UFO

-
tyrosine-protein kinase receptor UFO
-
tyrosine-protein kinase RYK

-
tyrosine-protein kinase RYK
-
tyrosine-protein kinase transforming protein erbB

-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transforming protein kit

-
tyrosine-protein kinase transforming protein kit
-
tyrosine-protein kinase transmembrane receptor ROR1

-
tyrosine-protein kinase transmembrane receptor ROR1
-
tyrosine-protein kinase transmembrane receptor ROR2

-
tyrosine-protein kinase transmembrane receptor ROR2
-
tyrosine-protein kinase Wzc

-
tyrosine-protein kinase Wzc
-
tyrosine-protein kinase Wzc
-
tyrosine-protein kinase Wzc
-
tyrosine-protein kinase Wzc
-
vascular endothelial growth factor receptor

-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor
-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor
-
-
vascular endothelial growth factor receptor
-
vascular endothelial growth factor receptor 1

-
vascular endothelial growth factor receptor 1
-
vascular endothelial growth factor receptor 2

-
vascular endothelial growth factor receptor 2
-
-
vascular endothelial growth factor receptor 2
-
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 3

-
vascular endothelial growth factor receptor 3
-
VEGF receptor

-
VEGF receptor tyrosine kinase

-
-
VEGF receptor tyrosine kinase
-
-
VEGFR

-
-
VEGFR-2

-
-
VEGFR1

-
-
VEGFR2

-
-
additional information

-
EGFR tyrosine kinase, Her1 tyrosine kinase, ErbB1 tyrosine kinase are part of the plasma membrane receptor tyrosine kinase family
additional information
-
epidermal growth factor receptor is a member of the Erb family
additional information
-
Kit receptor is a type III protein-tyrosine kinase
additional information
-
the enzyme is a member of receptor-mediated PTK family
additional information
-
the enzyme is a member of the FGFR family
additional information
-
WebB and HER receptor protein-tyrosine kinase, as well as epidermal growth factor receptor belong to the ErbB family, overview
additional information
the enzymes belong to the epidermal growth factor receptor family, i.e. EGFR/ErbB family
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ATP + a protein
ADP + a phosphoprotein
ATP + a [macrophage-stimulating protein]-L-tyrosine
ADP + a [macrophage-stimulating protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
ATP + Ac-DYFE-6-chloro-W-NHMe
ADP + Ac-DYpFE-6-chloro-W-NHMe
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
?
ATP + Ac-DYFGW-NHMe
ADP + Ac-DYpFGW-NHMe
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
?
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
-
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
-
-
tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
?
ATP + KKHTDDGYMPMSPGVA
ADP + KKHTDDGY-phosphate-MPMSPGVA
-
commercial peptide substrate
-
?
ATP + KKSRGDYMTMQIG
ADP + KKSRGDY-phosphate-MTMQIG
-
commercial peptide substrate
-
?
ATP + NAEYLRV
ADP + NAE-phospho-Y-LRV
-
-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
-
-
-
?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
-
-
-
?
ATP + phosphatidylinositol 3-kinase
ADP + phosphorylated phosphatidylinositol 3-kinase
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
?
ATP + phosphoinositide-dependent kinase-1-L-tyrosine
ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate
-
insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
-
-
-
?
ATP + poly(Glu-Ala-Tyr)
ADP + poly(Glu-Ala-Tyr)-L-tyrosine phosphate
-
-
-
?
ATP + poly(Glu:Tyr)
ADP + phosphorylated poly(Glu:Tyr)
-
-
?
ATP + poly(Glu:Tyr)
ADP + poly(Glu:Tyr) phosphate
-
-
-
?
ATP + poly-(Glu-Tyr)
ADP + poly-(Glu-Tyr) phosphate
-
-
Tyr-phosphate
?
ATP + poly-Ala-Glu-Lys-Tyr
ADP * poly-Ala-L-Glu-L-Lys-L-tyrosine phosphate
-
substrate used for c-Met
-
?
ATP + poly-Glu-Tyr
ADP + poly-L-Glu-L-tyrosine phosphate
-
substrate used for EGFR
-
?
ATP + protein
ADP + protein tyrosine phosphate
ATP + protein tyrosine
ADP + protein tyrosine phosphate
ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
ATP + VPEYINQ
ADP + VPE-phosphoY-INQ
-
-
?
ATP + YFEW
ADP + YpFEW
tetrapeptide identified by substrate profiling
-
?
ATP + [beta-catenin]-Tyr142
ADP + [beta-catenin]-Tyr142 phosphate
-
isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes
-
?
ATP + [endothelial growth-factor]-L-tyrosine
ADP + [endothelial growth-factor]-L-tyrosine phosphate
-
EGFR tyrosine kinase
-
?
ATP + [flagellin]-L-tyrosine
ADP + [flagellin]-L-tyrosine phosphate
-
-
-
?
ATP + [gastrin]-L-tyrosine
ADP + [gastrin]-L-tyrosine phosphate
-
-
-
?
ATP + [minigastrin]-L-tyrosine
ADP + [minigastrin]-L-tyrosine phosphate
-
-
-
?
ATP + [poly-(Glu,Tyr)1:4]
ADP + [poly-(Glu,Tyr)1:4]-tyrosine phosphate
-
synthetic substrate
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine
ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
-
VEGFR-1 tyrosine kinase
-
?
poly(Glu:Tyr) + ATP
ADP + ?
-
-
-
?
poly(Glu:Tyr) + ATP
ADP + poly(Glu:Tyr) phosphate
-
-
-
?
additional information
?
-
ATP + a protein

ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a [protein]-L-tyrosine

ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
660725, 660873, 660919, 660921, 661030, 661457, 662724, 662856, 671353, 672917, 673212, 674028, 674071, 674681, 676130, 677222, 677234, 703980, 704074, 705866, 737744, 737815, 737818, 737820, 737823, 737831, 738624 -
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
FLT-3 is involved in signal transduction, mechanisms
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
phosphorylation of downstream signalling proteins
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in e.g. gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase, regulation mechanism, overview
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
substrate binding and active structure
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
substrates are membrane and cytosolic proteins
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + G protein-coupled receptor kinase-2

ADP + phosphorylated G protein-coupled receptor kinase-2
-
GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
-
activates GRK2 by tyrosine phosphorylation at Y13, Y86, and Y92, the wild-type PDGFRbeta is 60fold more active with GRK2 than PDGFRbeta mutant Y857F, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
?
ATP + insulin receptor substrate 1-L-tyrosine

ADP + insulin receptor substrate 1-L-tyrosine phosphate
-
peptide derived from the regulatory domain of insulin receptor
-
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
-
-
tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
?
ATP + phospholipase C gamma

ADP + phosphorylated phospholipase C gamma
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo
-
?
ATP + protein

ADP + protein tyrosine phosphate
autophosphorylation
-
?
ATP + protein
ADP + protein tyrosine phosphate
Y602 is a major site of in vitro autophosphorylation in Sek, Y596 is phosphorylated to a lower stoichiometry
-
?
ATP + protein
ADP + protein tyrosine phosphate
intrinsic autophosphorylation activity
-
?
ATP + protein tyrosine

ADP + protein tyrosine phosphate
autophosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
protein kinase activity with specificity for tyrosine residues
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
specific for tyrosine
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
autophosphorylated on tyrosine and also mediated tyrosine phosphorylation of casein
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
autophosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
IRS-1 and IRS-2 proteins serve as substrates
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
autophosphorylation
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
major sites of autophosphorylation are in the region containing Tyr670, Tyr674, and Tyr675
-
?
ATP + tyrosine-protein kinase Wcz

ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation at several tyrosine residues
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
presence of at least five isoforms, all phosphorylated exclusively at tyrosine supports the concept that autophosphorylation occurs at multiple sites within the protein
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
efficient autophosphorylation in presence of ATP
-
?
additional information

?
-
no phosphorylation of synthetic substrates such as poly(Glu80 Tyr20) or angiotensin II
-
?
additional information
?
-
-
no phosphorylation of synthetic substrates such as poly(Glu80 Tyr20) or angiotensin II
-
?
additional information
?
-
possible involvement of the enzyme in cell recognition and bacterial pathogenicity
-
?
additional information
?
-
-
possible involvement of the enzyme in cell recognition and bacterial pathogenicity
-
?
additional information
?
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells
-
?
additional information
?
-
transformation of fibroblasts and transformation of erythroid cells
-
?
additional information
?
-
the erB oncogene efficiently transforms erythroblasts
-
?
additional information
?
-
-
the erB oncogene efficiently transforms erythroblasts
-
?
additional information
?
-
the erB oncogene efficiently transforms erythroblasts
-
?
additional information
?
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells
-
?
additional information
?
-
transformation of fibroblasts and transformation of erythroid cells
-
?
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
?
additional information
?
-
autophosphorylation
-
?
additional information
?
-
-
autophosphorylation
-
?
additional information
?
-
functions in neural and epithelial morphogenesis
-
?
additional information
?
-
-
functions in neural and epithelial morphogenesis
-
?
additional information
?
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
?
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
?
additional information
?
-
receptor for the inductive signal required for vulval development
-
?
additional information
?
-
-
receptor for the inductive signal required for vulval development
-
?
additional information
?
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
?
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
?
additional information
?
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
?
additional information
?
-
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
?
additional information
?
-
may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system
-
?
additional information
?
-
-
EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
?
additional information
?
-
generalized function of the Zek1 receptor in neuronal cell ontogeny
-
?
additional information
?
-
-
generalized function of the Zek1 receptor in neuronal cell ontogeny
-
?
additional information
?
-
important role in neurogenesis
-
?
additional information
?
-
the neurotrophic receptor may function during early stages of neural development
-
?
additional information
?
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
?
additional information
?
-
essential for migration of tracheal and specific midline glial cells
-
?
additional information
?
-
required for directed tracheal cell extension
-
?
additional information
?
-
part of a novel signal transduction cascade involved in learning and memory
-
?
additional information
?
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
?
additional information
?
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
?
additional information
?
-
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
?
additional information
?
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
?
additional information
?
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
?
additional information
?
-
enzyme is required for normal eye development
-
?
additional information
?
-
-
enzyme is required for normal eye development
-
?
additional information
?
-
enzyme is involved in signal transduction
-
?
additional information
?
-
involved in exopolysaccharide production and virulence
-
?
additional information
?
-
-
involved in exopolysaccharide production and virulence
-
?
additional information
?
-
phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
-
?
additional information
?
-
phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
-
?
additional information
?
-
phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
-
?
additional information
?
-
enzyme is involved in the production of the extracellular polysaccharide colanic acid
-
?
additional information
?
-
-
mutations in the glycine-riche loop of MET can cause papillary renal-cell carcinomas
-
?
additional information
?
-
-
protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview
-
?
additional information
?
-
-
poor activity on free amino acids, consensus sequence of InRK is YM-MM, and of EGFR E-EEYF
-
?
additional information
?
-
may play an important role during development and in signal transduction pathways
-
?
additional information
?
-
-
may play an important role during development and in signal transduction pathways
-
?
additional information
?
-
Cek9 plays an active role in embryonic signal transduction pathways
-
?
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
?
additional information
?
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
?
additional information
?
-
autophosphorylation
-
?
additional information
?
-
autophosphorylation
-
?
additional information
?
-
-
autophosphorylation
-
?
additional information
?
-
alternative splicing of the FGFR2 gene in the region encoding the carboxyl-terminal half of the third immunoglobulin domain determines the ligand specificity of this group of receptors
-
?
additional information
?
-
-
alternative splicing of the FGFR2 gene in the region encoding the carboxyl-terminal half of the third immunoglobulin domain determines the ligand specificity of this group of receptors
-
?
additional information
?
-
involved in cell-cell interactions
-
?
additional information
?
-
-
involved in cell-cell interactions
-
?
additional information
?
-
mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
-
?
additional information
?
-
-
mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
-
?
additional information
?
-
amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process
-
?
additional information
?
-
-
amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process
-
?
additional information
?
-
plays an important role in cell growth control
-
?
additional information
?
-
-
plays an important role in cell growth control
-
?
additional information
?
-
implicated in the control of cell growth and differentiation
-
?
additional information
?
-
implicated in the control of cell growth and differentiation
-
?
additional information
?
-
enzyme functions as the cell surface receptor for the macrophage colony stimulating factor
-
?
additional information
?
-
-
enzyme functions as the cell surface receptor for the macrophage colony stimulating factor
-
?
additional information
?
-
cell-surface receptor for an as-yet-unknown ligand
-
?
additional information
?
-
-
cell-surface receptor for an as-yet-unknown ligand
-
?
additional information
?
-
missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas
-
?
additional information
?
-
-
missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas
-
?
additional information
?
-
functions as a cell surface receptor for an as yet unidentified ligand
-
?
additional information
?
-
-
functions as a cell surface receptor for an as yet unidentified ligand
-
?
additional information
?
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piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor
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piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor
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human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene
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human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene
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mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
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mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
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mutations in the fibroblast growth factor receptor-1 gene, which maps to 8p, cause one form of familial Pfeiffer syndrome. A C to G transversion in exon 5, predicting a proline to arginine substitution in the putative extracellular domain, is identified in all affected members of five unrelated PS families but not in any unaffected individuals
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Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2
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Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2
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IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
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IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
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FGFR2 mutations in Pfeiffer syndrome
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ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors
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ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors
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high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
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high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
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FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor
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FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor
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tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor
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tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor
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receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1
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receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1
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gene plays important role in embryonic development and carcinogenesis of the stomach
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gene plays important role in embryonic development and carcinogenesis of the stomach
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may be involved in tumor progression of epithelial ovarian cancer
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may be involved in tumor progression of epithelial ovarian cancer
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enzyme is a receptor for vascular endothelial cell growth factor
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plays a part in human neurogenesis, DRT gene may play a part in neuroblastoma and SCLC tumorigenesis
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