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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase
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2.7.10.1 receptor protein-tyrosine kinaseIUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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- 2.7.10.1
- angiogenesis
-
nsclc
-
non-small
- myeloid
- adenocarcinoma
- estrogen
- vessel
- node
- marrow
-
autophosphorylation
-
3-kinase
- phosphatidylinositol
- gastrointestinal
- mesenchymal
- metastases
-
angiogenic
-
progression-free
- colorectal
- progesterone
- tumorigenesis
- actin
- prostate
- ovarian
-
first-line
-
signal-regulated
-
autocrine
- obesity
- neoplasm
-
neurotrophic
- adipocytes
- neck
-
radiotherapy
- sarcoma
- glioblastoma
- endocrine
-
integrins
-
relapse
-
oncology
-
monotherapy
- neovascularization
- medicine
- synthesis
- drug development
- analysis
- pharmacology
The enzyme appears in viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, egf receptor, erbb2, her-2, receptor tyrosine kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Adhesion-related kinase
ALK
ALK tyrosine kinase receptor
alpha platelet-derived growth factor receptor
Anaplastic lymphoma kinase
angiopoietin 1 receptor
Axl
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
BDNF/NT-3 growth factors receptor
beta platelet-derived growth factor receptor
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
c-kit
c-Kit receptor tyrosine kinase
c-Kit tyrosine kinase
-
-
-
-
C-mer
c-met
c-Met receptor tyrosine kinase
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
discoidin domain receptor 2
Discoidin receptor tyrosine kinase
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
DTK
EBK
EGF receptor
EGF receptor tyrosine kinase
EGF-R
Egfr
EGFR protein tyrosine kinase
EGFr TK
-
-
-
-
EGFR tyrosine kinase
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
EphA1
EphA2
ephrin type-A receptor 2
ephrin type-A receptor 3
ephrin type-A receptor 4
ephrin type-A receptor 5
ephrin type-A receptor 7
ephrin type-A receptor 8
ephrin type-B receptor 1
ephrin type-B receptor 2
ephrin type-B receptor 3
ephrin type-B receptor 4
epidermal growth factor receptor
epidermal growth factor receptor tyrosine kinase
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
epithelial discoidin domain receptor 1
erbB tyrosine kinase
-
-
-
-
ErbB-2
ErbB-4 tyrosine kinase
ERBB1
ErbB2
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
ERK
ETK
-
-
-
-
FGFR
FGFR2
FGFR3
FGFR4
fibroblast growth factor receptor
fibroblast growth factor receptor 1
fibroblast growth factor receptor 2
fibroblast growth factor receptor 3
fibroblast growth factor receptor 4
fibroblast growth factor receptor homolog 2
-
FL cytokine receptor
Flk-1
FLT3
Fms proto-oncogene
-
-
-
-
GCTK
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
HER2
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
high affinity nerve growth factor receptor
hydroxyaryl-protein kinase
-
-
-
-
HYK
IGF-1R
IGF-IR
ILP receptor
insulin receptor
insulin receptor kinase
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor tyrosine kinase
insulin receptor-related protein
insulin-like growth factor I receptor
insulin-like growth factor type I receptor
insulin-like receptor
IR-related receptor
-
-
-
-
IRK
IRR
KDR
Keratinocyte growth factor receptor
KGF receptor
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
KIT
Kit protein-tyrosine kinase
Let-23 receptor protein-tyrosine kinase
-
leukocyte tyrosine kinase receptor
Linotte protein
-
-
-
-
macrophage colony stimulating factor I receptor
macrophage colony-stimulating factor receptor
macrophage-stimulating protein receptor
mast/stem cell growth factor receptor
MEK4
-
-
-
-
MET
Met proto-oncogene tyrosine kinase
-
-
-
-
Met receptor-tyrosine kinase
Met RTK
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
muscle-specific receptor tyrosine kinase
MuSK
NET
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
neurotrophin tyrosine receptor kinase
NRTK
-
-
-
-
NT-3 growth factor receptor
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF receptor
PDGF receptor tyrosine kinase
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR
PDGFR kinase
-
-
-
-
PDGFR-alpha
PDGFR-beta
PDGFRbeta
platelet-derived growth factor receptor
platelet-derived growth factor receptor alpha
Protein tyrosine kinase
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
proto-oncogene tyrosine-protein kinase MER
proto-oncogene tyrosine-protein kinase receptor ret
PTK
recepteur d'origine nantais
recepteur d'origine nantais receptor tyrosine kinase
receptor protein-tyrosine kinase erbB-2
receptor protein-tyrosine kinase erbB-3
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
receptor tyrosine kinase
receptor tyrosine kinase c-Kit
receptor tyrosine kinase EphA2
Receptor tyrosine kinase MerTK
-
-
-
-
receptor tyrosine kinase RET
receptor tyrosine kinase Ror2
Receptor-activated Janus kinase
-
-
-
-
Ret receptor tyrosine kinase
Ron
RON receptor tyrosine kinase
ROR1
RPTK
RTK
RTKs
SCFR
-
-
-
-
sevenless protein
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
STK
Tie1
Tie2
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkA
trkB
TrkB receptor
TrkB tyrosine kinase
-
-
-
-
TrkC
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
Tyrosine kinase receptor HD-14
-
-
-
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
tyrosine-protein kinase Etk
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
tyrosine-protein kinase receptor Tie-1
tyrosine-protein kinase receptor TYRO3
tyrosine-protein kinase receptor UFO
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
tyrosine-protein kinase RYK
Tyrosine-protein kinase SKY
-
-
-
-
tyrosine-protein kinase transforming protein erbB
tyrosine-protein kinase transforming protein kit
tyrosine-protein kinase transmembrane receptor Ror
-
tyrosine-protein kinase transmembrane receptor ROR1
tyrosine-protein kinase transmembrane receptor ROR2
tyrosine-protein kinase Wzc
vascular endothelial growth factor receptor
vascular endothelial growth factor receptor 1
vascular endothelial growth factor receptor 2
vascular endothelial growth factor receptor 3
Vascular permeability factor receptor
-
-
-
-
VEGF receptor
VEGF receptor tyrosine kinase
VEGFR
VEGFR-2
VEGFR1
VEGFR2
additional information
Adhesion-related kinase
-
-
-
-
Anaplastic lymphoma kinase
-
-
-
-
basic fibroblast growth factor receptor 1
-
basic fibroblast growth factor receptor 1
-
beta platelet-derived growth factor receptor
-
c-fms
-
-
-
-
c-kit
-
-
-
-
C-mer
-
-
-
-
c-met
-
-
-
-
Discoidin receptor tyrosine kinase
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
-
-
-
-
Egfr
-
-
-
-
Egfr
-
-
epidermal growth factor receptor
-
-
epidermal growth factor receptor tyrosine kinase
-
-
Epithelial cell kinase
-
-
-
-
epithelial discoidin domain receptor 1
-
ERK
-
-
-
-
fibroblast growth factor receptor 2
-
fibroblast growth factor receptor 3
-
FL cytokine receptor
-
GCTK
-
-
-
-
HEK
-
-
-
-
hepatocyte growth factor receptor
-
HYK
-
-
-
-
ILP receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
-
macrophage colony stimulating factor I receptor
-
macrophage colony stimulating factor I receptor
-
mast/stem cell growth factor receptor
-
NET
-
-
-
-
platelet-derived growth factor receptor
-
-
receptor tyrosine kinase
-
-
RTK
-
-
-
-
RTK
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
tyrosine-protein kinase transforming protein erbB
-
tyrosine-protein kinase transmembrane receptor ROR2
-
tyrosine-protein kinase Wzc
-
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 2
-
additional information
-
EGFR tyrosine kinase, Her1 tyrosine kinase, ErbB1 tyrosine kinase are part of the plasma membrane receptor tyrosine kinase family
additional information
-
epidermal growth factor receptor is a member of the Erb family
additional information
-
WebB and HER receptor protein-tyrosine kinase, as well as epidermal growth factor receptor belong to the ErbB family, overview
additional information
the enzymes belong to the epidermal growth factor receptor family, i.e. EGFR/ErbB family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
reaction mechanism; regulation of enzyme activity involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated
-
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
active site structure, activation mechanism
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a [macrophage-stimulating protein]-L-tyrosine
ADP + a [macrophage-stimulating protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + Ac-DYFE-6-chloro-W-NHMe
ADP + Ac-DYpFE-6-chloro-W-NHMe
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
-
?
ATP + Ac-DYFGW-NHMe
ADP + Ac-DYpFGW-NHMe
substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
ATP + insulin receptor substrate 2-L-tyrosine
ADP + insulin receptor substrate 2-L-tyrosine phosphate
-
-
tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
-
?
ATP + KKHTDDGYMPMSPGVA
ADP + KKHTDDGY-phosphate-MPMSPGVA
-
commercial peptide substrate
-
-
?
ATP + KKSRGDYMTMQIG
ADP + KKSRGDY-phosphate-MTMQIG
-
commercial peptide substrate
-
-
?
ATP + phosphatidylinositol 3-kinase
ADP + phosphorylated phosphatidylinositol 3-kinase
-
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
-
?
ATP + phosphoinositide-dependent kinase-1-L-tyrosine
ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate
-
insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1
-
-
?
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
-
-
-
-
?
ATP + poly-Ala-Glu-Lys-Tyr
ADP * poly-Ala-L-Glu-L-Lys-L-tyrosine phosphate
-
substrate used for c-Met
-
-
?
ATP + poly-Glu-Tyr
ADP + poly-L-Glu-L-tyrosine phosphate
-
substrate used for EGFR
-
-
?
ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
-
-
-
-
?
ATP + YFEW
ADP + YpFEW
tetrapeptide identified by substrate profiling
-
-
?
ATP + [beta-catenin]-Tyr142
ADP + [beta-catenin]-Tyr142 phosphate
-
isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes
-
-
?
ATP + [endothelial growth-factor]-L-tyrosine
ADP + [endothelial growth-factor]-L-tyrosine phosphate
-
EGFR tyrosine kinase
-
-
?
ATP + [flagellin]-L-tyrosine
ADP + [flagellin]-L-tyrosine phosphate
-
-
-
-
?
ATP + [minigastrin]-L-tyrosine
ADP + [minigastrin]-L-tyrosine phosphate
-
-
-
-
?
ATP + [poly-(Glu,Tyr)1:4]
ADP + [poly-(Glu,Tyr)1:4]-tyrosine phosphate
-
synthetic substrate
-
-
?
ATP + [vascular endothelial growth-factor-1]-L-tyrosine
ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate
-
VEGFR-1 tyrosine kinase
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
660725, 660873, 660919, 660921, 661030, 661457, 662724, 662856, 671353, 672917, 673212, 674028, 674071, 674681, 676130, 677222, 677234, 703980, 704074, 705866, 737744, 737815, 737818, 737820, 737823, 737831, 738624, 738710, 738744, 739054, 739206, 737700, 738611, 738457, 739039
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
FLT-3 is involved in signal transduction, mechanisms
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
phosphorylation of downstream signalling proteins
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in e.g. gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase, regulation mechanism, overview
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
substrate binding and active structure
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
substrates are membrane and cytosolic proteins
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
-
GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
-
?
ATP + G protein-coupled receptor kinase-2
ADP + phosphorylated G protein-coupled receptor kinase-2
-
activates GRK2 by tyrosine phosphorylation at Y13, Y86, and Y92, the wild-type PDGFRbeta is 60fold more active with GRK2 than PDGFRbeta mutant Y857F, independent of Gbetagamma subunits and phosphoinositide 3-kinase
-
-
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
-
peptide derived from the regulatory domain of insulin receptor
-
-
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
-
-
tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
-
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
-
-
-
?
ATP + phospholipase C gamma
ADP + phosphorylated phospholipase C gamma
-
growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo
-
-
ATP + protein
ADP + protein tyrosine phosphate
-
Y602 is a major site of in vitro autophosphorylation in Sek, Y596 is phosphorylated to a lower stoichiometry
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
-
intrinsic autophosphorylation activity
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
autophosphorylation
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
protein kinase activity with specificity for tyrosine residues
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
specific for tyrosine
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
autophosphorylated on tyrosine and also mediated tyrosine phosphorylation of casein
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
autophosphorylation
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
IRS-1 and IRS-2 proteins serve as substrates
-
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
autophosphorylation
-
-
-
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
-
-
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
phospholipase C-gamma 1 is directly phosphorylated by TrkB
-
?
ATP + protein tyrosine
ADP + protein tyrosine phosphate
-
major sites of autophosphorylation are in the region containing Tyr670, Tyr674, and Tyr675
-
-
-
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
autophosphorylation
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
autophosphorylation at several tyrosine residues
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
presence of at least five isoforms, all phosphorylated exclusively at tyrosine supports the concept that autophosphorylation occurs at multiple sites within the protein
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
autophosphorylation
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
-
efficient autophosphorylation in presence of ATP
-
-
?
additional information
?
-
-
no phosphorylation of synthetic substrates such as poly(Glu80 Tyr20) or angiotensin II
-
-
-
additional information
?
-
-
possible involvement of the enzyme in cell recognition and bacterial pathogenicity
-
-
-
additional information
?
-
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells
-
-
-
additional information
?
-
-
transformation of fibroblasts and transformation of erythroid cells
-
-
-
additional information
?
-
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
the erB oncogene efficiently transforms erythroblasts
-
-
-
additional information
?
-
-
N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells
-
-
-
additional information
?
-
-
transformation of fibroblasts and transformation of erythroid cells
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
functions in neural and epithelial morphogenesis
-
-
-
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
-
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
-
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
-
additional information
?
-
receptor for the inductive signal required for vulval development
-
-
-
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
-
additional information
?
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system
-
-
-
additional information
?
-
-
EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
generalized function of the Zek1 receptor in neuronal cell ontogeny
-
-
-
additional information
?
-
-
the neurotrophic receptor may function during early stages of neural development
-
-
-
additional information
?
-
-
Dnrk may play an important role in neural development during Drosophila embryogenesis
-
-
-
additional information
?
-
-
essential for migration of tracheal and specific midline glial cells
-
-
-
additional information
?
-
-
required for directed tracheal cell extension
-
-
-
additional information
?
-
-
part of a novel signal transduction cascade involved in learning and memory
-
-
-
additional information
?
-
-
receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition
-
-
-
additional information
?
-
-
essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection
-
-
-
additional information
?
-
activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations
-
-
-
additional information
?
-
-
determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf
-
-
-
additional information
?
-
-
sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila
-
-
-
additional information
?
-
enzyme is required for normal eye development
-
-
-
additional information
?
-
enzyme is involved in signal transduction
-
-
-
additional information
?
-
involved in exopolysaccharide production and virulence
-
-
-
additional information
?
-
-
phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
-
-
-
additional information
?
-
-
phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
-
-
-
additional information
?
-
-
enzyme is involved in the production of the extracellular polysaccharide colanic acid
-
-
-
additional information
?
-
-
mutations in the glycine-riche loop of MET can cause papillary renal-cell carcinomas
-
-
-
additional information
?
-
-
protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview
-
-
-
additional information
?
-
-
poor activity on free amino acids, consensus sequence of InRK is YM-MM, and of EGFR E-EEYF
-
-
-
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
-
additional information
?
-
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
-
additional information
?
-
-
alternative splicing of the FGFR2 gene in the region encoding the carboxyl-terminal half of the third immunoglobulin domain determines the ligand specificity of this group of receptors
-
-
-
additional information
?
-
-
mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
-
-
-
additional information
?
-
-
amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process
-
-
-
additional information
?
-
plays an important role in cell growth control
-
-
-
additional information
?
-
implicated in the control of cell growth and differentiation
-
-
-
additional information
?
-
implicated in the control of cell growth and differentiation
-
-
-
additional information
?
-
-
enzyme functions as the cell surface receptor for the macrophage colony stimulating factor
-
-
-
additional information
?
-
-
cell-surface receptor for an as-yet-unknown ligand
-
-
-
additional information
?
-
-
missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas
-
-
-
additional information
?
-
-
functions as a cell surface receptor for an as yet unidentified ligand
-
-
-
additional information
?
-
-
piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor
-
-
-
additional information
?
-
-
human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene
-
-
-
additional information
?
-
-
mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
-
-
additional information
?
-
-
mutations in the fibroblast growth factor receptor-1 gene, which maps to 8p, cause one form of familial Pfeiffer syndrome. A C to G transversion in exon 5, predicting a proline to arginine substitution in the putative extracellular domain, is identified in all affected members of five unrelated PS families but not in any unaffected individuals
-
-
-
additional information
?
-
-
Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2
-
-
-
additional information
?
-
-
IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family
-
-
-
additional information
?
-
ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors
-
-
-
additional information
?
-
-
high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
-
-
-
additional information
?
-
-
FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor
-
-
-
additional information
?
-
tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor
-
-
-
additional information
?
-
receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1
-
-
-
additional information
?
-
-
gene plays important role in embryonic development and carcinogenesis of the stomach
-
-
-
additional information
?
-
-
may be involved in tumor progression of epithelial ovarian cancer
-
-
-
additional information
?
-
-
enzyme is a receptor for vascular endothelial cell growth factor
-
-
-
additional information
?
-
-
plays a part in human neurogenesis, DRT gene may play a part in neuroblastoma and SCLC tumorigenesis
-
-
-
additional information
?
-
-
element of the complex signaling network involved in the control of cell proliferation and differentiation
-
-
-
additional information
?
-
-
involved in the proliferation of early progenitor/stem cells
-
-
-
additional information
?
-
-
Srcasm may help promote Src family kinase signaling in cells
-
-
-
additional information
?
-
-
enzyme is implicated in control of cell growth
-
-
-
additional information
?
-
-
NET potentially plays important roles in human neurogenesis
-
-
-
additional information
?
-
role for the Ron receptor in progression toward malignancy
-
-
-
additional information
?
-
-
distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B
-
-
-
additional information
?
-
-
recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by loss of ROR2 activity
-
-
-
additional information
?
-
-
dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
-
-
-
additional information
?
-
-
ron gene product is a specific cell-surface receptor for macrophage-stimulating protein
-
-
-
additional information
?
-
-
mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
-
-
-
additional information
?
-
-
vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
-
-
-
additional information
?
-
-
Sky may be involved in cell adhesion processes, particularly in the central nervous system
-
-
-
additional information
?
-
-
activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer
-
-
-
additional information
?
-
-
activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview
-
-
-
additional information
?
-
-
downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview
-
-
-
additional information
?
-
enzyme regulation via reversible autophosphorylation, binding to plasma membrane of enzyme and enzyme-derived peptides, overview
-
-
-
additional information
?
-
-
enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways
-
-
-
additional information
?
-
-
ErbB family enzymes are absolutely required for viability of embryos
-
-
-
additional information
?
-
-
insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia
-
-
-
additional information
?
-
-
insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta
-
-
-
additional information
?
-
-
PDGFRbeta wild-type and mutant Y857F activate c-Src kinase
-
-
-
additional information
?
-
-
platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs
-
-
-
additional information
?
-
-
the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview
-
-
-
additional information
?
-
-
the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has increasing effect, opposing to soluble protein kinase Src, on volume-sensitive chloride current in atrial myocytes
-
-
-
additional information
?
-
-
the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview
-
-
-
additional information
?
-
-
the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B
-
-
-
additional information
?
-
-
the receptor protein tyrosine kinases are involved in cell signaling processes and signal transduction pathways in regulation of cell growth, differentiation, migration and metabolism by catalyzing protein phosphorylation and dephosphorylation, overview, EGFR tyrosine kinase regulates cell proliferation, IGFR tyrosine kinase regulates cell survival, VEGFR tyrosine kinase regulates tumor angiogenesis, mechanisms, overexpression of receptor protein tyrosine kinases in cancers
-
-
-
additional information
?
-
-
autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism
-
-
-
additional information
?
-
-
serotonin 5-HT2c receptor signaling is largely independent from receptor tyrosine kinase activity
-
-
-
additional information
?
-
-
ErbB1 receptor shows three phosphorylation sites (Y1110, Y1172 and Y1192)
-
-
-
additional information
?
-
-
protein tyrosine kinases select substrates with a glutamic acid at the P-1 position and a large hydrophobic amino acid at the P+1 position
-
-
-
additional information
?
-
-
substrate recognition and binding structure, the enzyme depends on basic residues for substrate recognition, substrate specificity determinants in substrates
-
-
-
additional information
?
-
-
EGF-like peptides on the surface of coccidial parasites Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum bind as ligands to the extracellular domain of the gerbils' host cells' EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade
-
-
-
additional information
?
-
tyrosine kinase may play an important function in the developing mouse
-
-
-
additional information
?
-
important role in the formation of neuronal structures and possibly other morphogenic processes
-
-
-
additional information
?
-
receptor may play a role in the regulation of beta-cell mass
-
-
-
additional information
?
-
-
role for DDR2 in critical events during wound repair
-
-
-
additional information
?
-
required for cartilage and growth plate development
-
-
-
additional information
?
-
-
the proto-oncogene c-kit is involved in signal transduction
-
-
-
additional information
?
-
-
human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas
-
-
-
additional information
?
-
-
Ltk is expressed at a very low level in only a few cell lines and tissues and may be the receptor for a pre-B lymphocyte growth or differentiation factor
-
-
-
additional information
?
-
-
trkB may code for a cell surface receptor involved in neurogenesis
-
-
-
additional information
?
-
-
may play a role in vascular development and regulation of vascular permeability
-
-
-
additional information
?
-
-
Flk-1 as a major regulator of vasculogenesis and angiogenesis
-
-
-
additional information
?
-
possibility that overexpression of PDGF-alpha receptor in high-metastatic clones may contribute to an increase in the capacity of tumor cells to generate metastases in the lung
-
-
-
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
-
additional information
?
-
-
receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny
-
-
-
additional information
?
-
-
possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline
-
-
-
additional information
?
-
-
tyro3 may function as a novel neurotrophic factor receptor
-
-
-
additional information
?
-
important role in gestational growth and differentiation
-
-
-
additional information
?
-
ALK plays an important role in the development of the brain
-
-
-
additional information
?
-
-
important role for this kinase in CD2 co-stimulation of T cell responses
-
-
-
additional information
?
-
-
primary function is likely to be in developmental regulation
-
-
-
additional information
?
-
-
role for Tsk in early T-lymphocyte differentiation
-
-
-
additional information
?
-
-
the mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
-
-
-
additional information
?
-
ufo may function as a signal transducer between specific cell types of mesodermal origin
-
-
-
additional information
?
-
-
tek receptor tyrosine kinase may be critically involved in the determination and/or maintenance of cells of the endothelial lineage
-
-
-
additional information
?