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EC 4.4.1.20 Details

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EC number

4.4.1.20

Accepted name

leukotriene-C₄ synthase

Reaction

leukotriene C₄ = leukotriene A₄ + glutathione

Other name(s)

leukotriene C₄ synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A₄:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)

Systematic name

leukotriene-C₄ glutathione-lyase (leukotriene-A₄-forming)

CAS registry number

90698-32-1

Comment

The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.

History

created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

4.1 Carbon-carbon lyases

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

4.4.1.1 cystathionine γ-lyase

4.4.1.2 homocysteine desulfhydrase

4.4.1.3 dimethylpropiothetin dethiomethylase

4.4.1.4 alliin lyase

4.4.1.5 lactoylglutathione lyase

4.4.1.6 S-alkylcysteine lyase

4.4.1.7 created 1972, deleted 1976

4.4.1.8 cystathionine β-lyase

4.4.1.9 L-3-cyanoalanine synthase

4.4.1.10 cysteine lyase

4.4.1.11 methionine γ-lyase

4.4.1.12 created 1976, deleted 2003

4.4.1.13 cysteine-S-conjugate β-lyase

4.4.1.14 1-aminocyclopropane-1-carboxylate synthase

4.4.1.15 D-cysteine desulfhydrase

4.4.1.16 selenocysteine lyase

4.4.1.17 holocytochrome-c synthase

4.4.1.18 created 2000, deleted 2002

4.4.1.19 phosphosulfolactate synthase

4.4.1.20 leukotriene-C₄ synthase

4.4.1.21 S-ribosylhomocysteine lyase

4.4.1.22 S-(hydroxymethyl)glutathione synthase

4.4.1.23 2-hydroxypropyl-CoM lyase

4.4.1.24 (2R)-sulfolactate sulfo-lyase

4.4.1.25 L-cysteate sulfo-lyase

4.4.1.26 olivetolic acid cyclase

4.4.1.27 carbon disulfide lyase

4.4.1.28 L-cysteine desulfidase

4.4.1.29 phycobiliprotein cysteine-84 phycobilin lyase

4.4.1.30 phycobiliprotein β-cysteine-155 phycobilin lyase

4.4.1.31 phycoerythrocyanin α-cysteine-84 phycoviolobilin lyase/isomerase

4.4.1.32 C-phycocyanin α-cysteine-84 phycocyanobilin lyase

4.4.1.33 R-phycocyanin α-cysteine-84 phycourobilin lyase/isomerase

4.4.1.34 isoprene-epoxide—glutathione S-transferase

4.4.1.35 L-cystine β-lyase

4.4.1.36 hercynylcysteine S-oxide lyase

4.4.1.37 pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase

4.4.1.38 isethionate sulfite-lyase

4.4.1.39 C-phycoerythrin α-cysteine-82 phycoerythrobilin lyase

4.4.1.40 C-phycoerythrin β-cysteine-48/59 phycoerythrobilin lyase

4.4.1.41 (2S)-3-sulfopropanediol sulfolyase

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases

4.99 Other lyases

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Release 2023.1 (January 2023)