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2-hydroxychromene-2-carboxylic acid isomerase
-
-
alpha class glutathione transferase
alpha-class glutathione transferase
class mu glutathione S-transferase
-
-
delta class glutathione transferase
-
delta-class glutathione S-transferase
Delta-class glutathione transferase
Epsilon glutathione S-transferase
-
Epsilon glutathione transferase
-
-
epsilon-class glutathione S-transferase
-
-
epsilon-class glutathione transferase
-
glutathione S-alkyl transferase
-
-
-
-
glutathione S-aralkyltransferase
-
-
-
-
glutathione S-aryltransferase
-
-
-
-
glutathione S-transferase
glutathione S-transferase 2
-
-
glutathione S-transferase A1-1
-
-
glutathione S-transferase A3-3
-
-
glutathione S-transferase AdFSTD3-3
-
-
glutathione S-transferase I
-
-
glutathione S-transferase omega 1
-
glutathione S-transferase omega 2
-
glutathione S-transferase P1-1
glutathione S-transferase pi
-
glutathione S-transferase Pi-1
-
glutathione S-transferase X
-
-
-
-
glutathione S-transferases
glutathione transferase A1-1
glutathione transferase A4-4
-
-
glutathione transferase M1-1
-
-
glutathione transferase M2-2
-
-
glutathione transferase Omega 3S
-
glutathione transferase omega-1
-
-
glutathione transferase P1-1
glutathione transferase Pi
-
glutathione transferase T1-1
-
glutathione transferase zeta
-
-
glutathione transferase zeta 1
-
glutathione transferase Zeta 1-1
-
variants glutathione transferase Zeta 1a-1a, glutathione transferase Zeta 1b-1b, glutathione transferase Zeta 1c-1c, glutathione transferase Zeta 1d-1d
glutathione transferase zeta1-1
-
glutathione transferase-like protein
-
-
glutathione-S-transferas
-
-
glutathione-S-transferase
glutathione-S-transferase pi
-
glutathione-transferase
-
GSH S-transferase
-
-
-
-
GSH transferase homologue
-
-
GSH-S transferase rho
-
-
GST-OCX-32
fusion protein
GSTF5
-
phi class isozyme
GSTS2
sigma class isozyme
Hematopoietic prostaglandin D synthase
-
-
kappa class glutathione transferase
kappa class GSH transferase
-
-
lambda glutathione transferase
-
-
microsomal glutathione transferase 1
-
-
microsomal glutathione transferase-1
membrane-bound enzyme with both glutathione transferase and hydroperoxidase activities
mu class glutathione S-transferase
-
mu glutathione transferase
-
-
mu-class glutathione S-transferase
-
-
mu-class glutathione S-transferase1
-
nu-class glutathione transferase
-
-
omega glutathione S-transferase
-
-
omega glutathione transferase
-
omega-class glutathione S-transferase
-
omega-class glutathione S-transferase 2
-
phi class glutathione transferase
-
-
rho class glutathione S-transferase
-
-
RX: glutathione R-transferase
-
-
RX:glutathione R-transferase
S-(hydroxyalkyl)glutathione lyase
-
-
-
-
selenium-containing glutathione transferase zeta1-1
-
-
SGST26.5
-
isoform of 26500 Da
sigma class glutathione transferase
-
-
sigma glutathione S-transferase
-
sigma-class glutathione S-transferase
tau class glutathione S-transferase
tau class glutathione transferase
theta class glutathione S-transferase
-
theta class glutathione transferase T1-1
theta-class glutathione transferase
thiol-dependent reductase I
-
-
Xi class glutathione transferase
zeta class glutathione S-transferase
-
-
26GST

-
-
alpha class glutathione transferase

-
alpha class glutathione transferase
-
alpha class glutathione transferase
-
-
alpha class glutathione transferase
-
alpha GST

-
alpha-class glutathione transferase

-
alpha-class glutathione transferase
-
-
AtuGSTH1-1

-
-
BaeAB

Q2G4B4; Q2G4B5
-
beta-etherase

Q2G4B4; Q2G4B5
-
beta-etherase
Q2G4B4; Q2G4B5
-
-
cGST

-
-
Chi class GST

-
-
Chi GST

-
-
delta-class glutathione S-transferase

-
delta-class glutathione S-transferase
-
delta-class glutathione S-transferase
-
-
Delta-class glutathione transferase

-
-
Delta-class glutathione transferase
-
GHR

-
glutathione S-transferase

-
-
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
formerly
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
Coturnix sp.
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
a rho-class glutathione S-transferase
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
-
glutathione S-transferase
-
glutathione S-transferase
Q2G4B4; Q2G4B5
-
glutathione S-transferase
Q2G4B4; Q2G4B5
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
-
glutathione S-transferase
-
-
glutathione S-transferase
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
O04437, P30110, P30111, Q6U6G6, Q8GRI3, Q8GTB7, Q8GTB8, Q8GTB9, Q8GTC0, Q8GTC1, Q8LGN5, Q8LGN6, Q8LL15, Q8RW00, Q8RW01, Q8RW02, Q8RW03, Q8RW04, Q9SP56 -
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase P1-1

-
-
glutathione S-transferase P1-1
-
glutathione S-transferases

-
-
glutathione S-transferases
-
glutathione S-transferases
-
glutathione S-transferases
-
-
glutathione transferase

-
-
glutathione transferase
-
-
-
glutathione transferase
-
-
glutathione transferase
-
-
glutathione transferase A1-1

-
-
glutathione transferase A1-1
-
glutathione transferase A1-1
-
glutathione transferase A1-1
-
-
glutathione transferase P1-1

-
-
glutathione transferase P1-1
-
glutathione transferase P1-1
-
glutathione-S-transferase

-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
A0A023JBX1, A0A023JBX8, A0A023JCA5, A0A023JCC0, A0A023JCF9, A0A023JCM9, A0A023JCN4, A0A023JCQ9, A0A023JCR5, G7P4V9, G7P5X8, Q2PFL7 -
glutathione-S-transferase
A0A023JBX5, A0A023JCA8, A0A023JCQ7, A0A023JCR6, F6TP78, F6WWX7, F6Z1G0, F7H5D7, G7N132, G8F1C9, H9Z845, I0FRI5 -
glutathione-S-transferase
-
isozymes alpha
glutathione-S-transferase
-
isozymes mu
glutathione-S-transferase
-
isozymes pi
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
GST

-
GST
A0A4Y5QZW9, A0A4Y5QZX0, A0A4Y5QZX2, A0A4Y5QZX3, A0A4Y5QZX9, A0A4Y5QZZ8, A0A4Y5R032, A0A4Y5R087, A0A4Y5R0B2, A0A4Y5R0C1, A0A4Y5R0K8, A0A4Y5R0L5, A0A4Y5R2M7, A0A4Y5R2N2 -
GST
O04437, P30110, P30111, Q6U6G6, Q8GRI3, Q8GTB7, Q8GTB8, Q8GTB9, Q8GTC0, Q8GTC1, Q8LGN5, Q8LGN6, Q8LL15, Q8RW00, Q8RW01, Q8RW02, Q8RW03, Q8RW04, Q9SP56 -
GST A1-1

-
isozyme
GST A2-2

-
isozyme
GST A3-3

isozyme
GST I

-
isozyme
GST M1-1

-
originally called GST mu
GST M2-2

-
-
GST P1-1

-
-
GST pi

-
GST T1-1

-
-
GST-1

-
GST1

-
-
GST2

isoform
GST3

isoform
GST4

-
GST5

-
GSTA1-1

isozyme
GSTA2-2

-
GSTA3

-
isoform
GSTA3-3

-
GSTA4

-
isoform
GSTA4-4

-
-
GSTA5

isoform
GSTD

-
GSTD1

-
-
GSTD10

-
-
GSTE2

-
-
GSTE6

-
-
GSTE7

-
-
GSTF3

-
phi class isozyme
GSTFuA1

-
isoform
GSTK1

-
isoform
GSTM1-1

-
-
GSTM2

-
isoform
GSTM3

-
isoform
GSTM4

-
isoform
GSTO1

-
isoform
GSTO1-1

-
-
GSTO2

-
isoform
GSTP

-
isoform
GSTP1

-
isoform
GSTP1-1

-
isoenzyme
GSTS

-
GSTS1

-
-
GSTS1
sigma class isozyme
GSTT1

-
-
GSTT1-1

-
GSTT2

isoform
GSTU1

-
-
GSTU12

-
isoform
GSTU13

isoform
GSTU17

isoform
GSTU19

-
GSTU2

isoform
GSTU26

-
-
GSTU3

isoform
GSTU3
-
tau class isozyme
GSTU4

isoform
GSTU4
-
tau class isozyme
GSTU5

isoform
GSTU5
-
tau class isozyme
GSTU9

isoform
Gstz1

-
isoform
GTT1.2

-
isoform
kappa class glutathione transferase

-
-
kappa class glutathione transferase
-
-
MGST1

-
isoform
MGST2

-
isoform
mtMGST1

-
-
Omega class GST

-
pGSTA1

-
PtGSTU1

-
-
RX:glutathione R-transferase

-
RX:glutathione R-transferase
-
-
Saro_2873/Saro_2872

Q2G4B4; Q2G4B5
-
Saro_2873/Saro_2872
Q2G4B4; Q2G4B5
-
-
Sigma class GST

-
sigma-class glutathione S-transferase

-
sigma-class glutathione S-transferase
-
ssGST3

-
ssGST5

-
tau class glutathione S-transferase

-
tau class glutathione S-transferase
-
tau class glutathione transferase

-
-
tau class glutathione transferase
-
tau class glutathione transferase
-
tau class glutathione transferase
-
tau class glutathione transferase
-
-
tau class glutathione transferase
-
theta class glutathione transferase T1-1

-
theta class glutathione transferase T1-1
-
-
theta class glutathione transferase T1-1
-
-
theta class GST

-
theta-class glutathione transferase

-
-
theta-class glutathione transferase
-
-
Xi class glutathione transferase

-
Xi class glutathione transferase
-
-
Ya-GST

-
-
additional information

two major GST subunits are mu-class GSTs, one minor GST subunit is a putative theta-class GST
additional information
two major GST subunits are mu-class GSTs, one minor GST subunit is a putative theta-class GST
additional information
-
the enzyme belongs to the glutathione-S-transferase family of multifunctional enzymes
additional information
maleylacetoacetate isomerase, EC 5.2.1.2, bifunctional enzyme
additional information
the Necator americanus GST isozymes belong to a nematode-specific nu-class GST family
additional information
the enzyme belongs to the family of glutathione S-transferases
additional information
cf. EC 1.11.1.9
additional information
-
MGST1 that belongs to the membrane associated proteins in eicosanoid and glutathione metabolism, MAPEG, superfamily
additional information
-
overview of nomenclature of rat glutathione transferase isoenzymes
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(+)-2-bromo-3-(4-nitrophenyl)propanoic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid + HBr
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
(2,3-dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid + glutathione
?
-
i.e. ethacrynic acid
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
1,1-dichloro-2,2-bis-(4-chlorophenyl)ethylene + ?
i.e. DDT, modeling of DDT into the putative DDT-binding pocket, catalytic mechanism of isozyme agGSTe2 that shows high activity through the inclination of the upper part of H4 helix, H4'' helix, which brings residues Arg112, Glu116, and Phe120 closer to the GSH-binding site resulting in a more efficient GS- stabilizing hydrogen-bond-network and higher DDT-binding affinity, overview
product formation through an elimination reaction triggered by the nucleophilic attack of the thiolate group of GS- on the beta-hydrogen of DDT
-
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
?
detoxification of the insecticide DDT, especially by isozyme agGSTe2
-
-
?
1,2-dichloro-4-nitrobenzene + glutathione
?
-
low activity
-
-
?
1,2-dichloro-4-nitrobenzene + glutathione
S-(2-chloro-4-nitro-phenyl)glutathione + HCl
binding structure with wild-type and mutant Y119E and F123A enzymes, overview
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione
?
1,2-epoxy-3-(p-nitrophenoxy)propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(p-nitrophenoxy)propane + GSH
?
-
-
-
-
?
1,3,5-triacryloyl-1,3,5-triazinane + glutathione
L-gamma-glutamyl-S-[3-(3,5-diacryloyl-1,3,5-triazinan-1-yl)-3-oxopropyl]-L-cysteinylglycine
-
-
-
-
?
1,3,5-trinitrobenzene + glutathione
S-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione
an anionic sigma-complex is formed between GSH and 1,3,5-trinitrobenzene and is stabilized by Arg15. The trinitrocyclohexadienate moiety of the sigma-complex binds the H-site where the catalytic residue, Tyr9, was identified to hydrogen bond to an o-nitro group of the sigma-complex
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
1-bromo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HBr
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
1-chloro-2,3-dinitrobenzene + GSH
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
?
1-chloro-2,4-dinitrobenzene + glutathione
chloride + L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)-glutathione + HCl
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrobenzyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
1-chloro-2,4-dinitrobenzene + GSH
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
1-iodo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
1-methyl-4-nitro-5-[(4-nitrophenyl)thio]-1H-imidazole + glutathione
?
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
10-S-glutathionyl-12-oxo-phytodienoic acid + H2O
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
?
-
-
-
?
2,3-hexadienal + GSH
?
-
at 7.5% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
2-chloro-5-nitropyridine + glutathione
chloride + L-gamma-glutamyl-S-(5-nitropyridin-2-yl)-L-cysteinylglycine
-
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
2-hydroxychromene-2-carboxylic acid + reduced glutathione
trans-o-hydroxybenzylidene pyruvic acid + ?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
3,4-dichloronitrobenzene + glutathione
?
-
-
-
?
4-chloro-7-nitrobenzofurazan + glutathione
?
-
-
-
-
?
4-hydroxy-(E)-2-nonenal + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
4-hydroxynonenal + glutathione
?
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
4-nitrobenzyl chloride + glutathione
S-(4-nitrophenyl)glutathione + HCl
4-nitrophenethyl bromide + glutathione
?
4-nitrophenethyl bromide + glutathione
S-(4-nitrophenyl)glutathione + HBr
-
-
-
?
4-nitrophenyl acetate + glutathione
?
-
-
-
?
4-nitrophenyl acetate + GSH
?
4-nitrophenyl butyrate + glutathione
S-(4-nitrophenyl)glutathione + butyrate
-
-
-
?
4-nitrophenylacetate + glutathione
?
-
-
-
-
?
4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
-
-
-
?
5-androstene-3,17-dione + glutathione
?
5-pregnene-3,20-dione + glutathione
?
5-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
7-chloro-4-glutathionylbenzo-2-oxa-1,3-diazole
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
7-oxabicyclo[4.1.0]heptan-2-one + glutathione
chloride + L-gamma-glutamyl-S-(6-oxocyclohex-1-en-1-yl)-L-cysteinylglycine
-
-
-
-
?
acetyl-gamma-Glu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
substrate for mutant enzyme I104V/A113V
-
-
?
alachlor + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
allyl-isothiocyanate + glutathione
?
-
-
-
?
aminochrome + glutathione
?
-
-
-
-
?
androstenedione + glutathione
?
-
-
-
-
?
atrazine + glutathione
?
-
-
-
-
?
atrazine + glutathione
atrazine-S-glutathione + HCl
-
-
-
-
?
azathioprine + glutathione
?
-
aromatic substitution. Wild-type hGST M2-2 has modest activity with azathioprine, but mutant C87A/C115A/C174A/M212C displays no detectable activity. The azathioprine activity of wild-type hGST M2-2 can be enhanced 30fold by two point mutations of other residues in the active site
-
-
?
benzyl isothiocyanate + glutathione
?
benzyl-isothiocyanate + glutathione
?
-
-
-
?
bromosulfophthalein + glutathione
?
-
-
-
-
?
bromosulfophthalein + GSH
?
brostallicin + glutathione
glutathionyl-brostallicin
butyl nitrite + glutathione
?
-
-
-
-
?
chlorofluoroacetic acid + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
cumene hydroperoxide + GSH
?
dehydroascorbate + glutathione
?
dehydroascorbic acid + glutathione
?
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
dichloroacetate + glutathione
2-(glutathion-S-yl)-chloroacetate + HCl
-
-
-
?
dichloroacetate + glutathione
glyoxylate + HCl + ?
-
-
-
-
?
dichloroacetic acid + glutathione
?
ethacrynic acid + glutathione
?
fluazifop-p-butyl + glutathione
?
-
-
-
-
?
fluorodifen + glutathione
?
gamma-Glu-Cys-Aib + 1-chloro-2,4-dinitrobenzene
?
substrate for mutant enzyme I104V/A113V
-
-
?
gamma-Glu-Cys-Nle + 1-chloro-2,4-dinitrobenzene
?
26.4% activity compared to glutathione
-
-
?
gamma-Glu-Cys-Nva + 1-chloro-2,4-dinitrobenzene
?
16% activity compared to glutathione
-
-
?
gamma-Glu-Cys-Sar + 1-chloro-2,4-dinitrobenzene
?
17% activity compared to glutathione
-
-
?
glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
-
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
glutathione + (2Z,4E)-3-chloro-6-(3,5-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
?
-
-
-
-
?
glutathione + (E)-2-hexenal
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + (R)-styrene-7,8-oxide
?
-
-
-
-
?
glutathione + (R,R)-1-phenylpropylene oxide
?
-
-
-
-
?
glutathione + (R,R)-trans-stilbene oxide
?
-
-
-
-
?
glutathione + (S)-styrene-7,8-oxide
?
-
-
-
-
?
glutathione + (S,S)-1-phenylpropylene oxide
?
-
-
-
-
?
glutathione + (S,S)-trans-stilbene oxide
?
-
-
-
-
?
glutathione + 1,2-dichloro-4,5-dinitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
glutathione + 1,2-diiodoethane
?
glutathione + 1,2-dinitrobenzene
?
glutathione + 1,2-epoxy-3-(4-nitro-phenoxy)propane
?
-
best substrate for the wild-type GST T1-1 and mutant W234K
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)-propane
?
-
substrate of the theta class isozyme
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
glutathione + 1,4-diiodobutane
?
glutathione + 1,6-diiodohexane
?
glutathione + 1,8-diiodooctane
?
glutathione + 1-bromo-4-nitrobenzene
bromide + 4-nitrophenyl-glutathione
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
glutathione + 1-chloro-2,3-dinitrobenzoate
?
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrobenzyl-glutathione
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + S-(2,4-dinitrophenyl)-glutathione
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrobenzyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
glutathione + 1-fluoro-2,4-dinitrobenzene
?
-
-
-
-
?
glutathione + 1-iodo-3-phenylpropane
iodide + 3-phenylpropyl-glutathione
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
glutathione + 1-iodoethane
iodide + ethylglutathione
-
-
-
-
?
glutathione + 1-iodoheptane
iodide + heptyl-glutathione
-
-
-
-
?
glutathione + 1-iodohexane
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
glutathione + 1-iodomethane
iodide + methylglutathione
glutathione + 1-iodooctane
iodide + octyl-glutathione
-
-
-
-
?
glutathione + 1-iodopentane
iodide + pentyl-glutathione
-
-
-
-
?
glutathione + 1-iodopropane
iodide + propyl-glutathione
-
-
-
-
?
glutathione + 1-menaphthyl sulfate
?
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
glutathione + 2,4-hexadienal
?
-
-
-
?
glutathione + 2,5-dinitrophenol
?
-
-
-
-
?
glutathione + 2-hydroxyethyl disulfide
?
isozyme GSTO2, low activity
-
-
?
glutathione + 2-methyl-4-nitrobenzyl alcohol
?
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
glutathione + 3,4-dinitrobenzanilide
?
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
glutathione + 3-iodopropylbenzene
?
glutathione + 4-chloro-3-nitroacetophenone
?
-
-
-
?
glutathione + 4-chloro-3-nitrobenzophenone
?
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
glutathione + 4-chloro-7-nitrobenzofurazan
?
-
8.2% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 4-fluoro-3-nitrobenzanilide
?
-
-
-
?
glutathione + 4-hydroxy-(E)-2-nonenal
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + 4-hydroxydecenal
?
-
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
glutathione + 4-hydroxynonenal
?
glutathione + 4-methylumbelliferyl acetate
?
-
-
-
?
glutathione + 4-nitrobenzo-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
glutathione + 4-nitrobenzyl chloride
chloride + 4,4'-dichlorodiphenyltrichloroethane
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrophenyl-glutathione
-
substrate of the alpha class isozyme
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + S-(4-nitrophenyl)-glutathione
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrophenyl)glutathione + HCl
glutathione + 4-nitrobenzylchloride
?
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
?
weak substrate
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenethyl-glutathione
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenylethyl-glutathione
-
-
-
?
glutathione + 4-nitrophenyl acetate
?
-
-
-
-
?
glutathione + 4-nitrophenyl acetate
S-(4-nitrophenyl)glutathione + HCl
-
-
-
?
glutathione + 4-nitrophenyl bromide
?
-
-
-
-
?
glutathione + 4-nitropyridine
?
-
-
-
-
?
glutathione + 4-nitroquinoline-1-oxide
?
-
-
-
-
?
glutathione + 5-chloromethylfluorescein diacetate
?
-
-
-
?
glutathione + 5-nitrofurfural
?
glutathione + 5-nitrofurfural diacetal
?
glutathione + 7-amino-4-chloromethyl coumarin
?
glutathione + 7-chloro-4-nitrobenz-2-oxa-1,3-diazole
?
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
glutathione + acetochlor
?
glutathione + adenine propenal
?
-
-
-
-
?
glutathione + allyl isothiocyanate
?
-
58.9% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + allyl-isothiocyanate
?
glutathione + alpha-O-(beta-methylumbelliferyl)acetovanillone
?
-
-
-
?
glutathione + androst-5-ene-3,17-dione
?
-
-
-
-
?
glutathione + anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide
?
-
-
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
glutathione + benzo[a]pyrene 4,5-oxide
?
glutathione + benzyl isothiocyanate
?
-
substrate of GSTF9
-
-
?
glutathione + beta-(2-methoxyphenoxy)-gamma-hydroxypropiovanillone
beta-(S)-hydroxypropiovanillonyl-glutathione + guaiacol
glutathione + bromosulfophthalein
?
glutathione + bromosulphthalein
?
glutathione + butachlor
?
glutathione + chlorambucil
?
-
-
-
?
glutathione + cis-6-(2-acetylvinylthio)purine
?
O15217, O43708, P08263, P09210, P09211, P09488, P28161, P30711, P46439, P78417, Q03013, Q16772 -
-
-
?
glutathione + crotonaldehyde
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + cryptophycin 52
?
glutathione + cryptophycin 53
?
glutathione + cumene hydroperoxide
?
glutathione + cyclohexyl-isothiocyanate
?
glutathione + dehydroascorbate
?
-
43.6% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + ethacrynic acid
?
glutathione + ethylene diiodide
?
-
-
-
?
glutathione + fenchlorim
?
-
-
-
-
?
glutathione + fenoxaprop
4-hydroxyphenoxypropanoic acid + glutathione conjugate
-
herbicide
-
?
glutathione + fluorodifen
4-nitrophenol + (2-nitro-4-trifluoromethylphenyl)glutathione
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
glutathione + fluorodifen
?
glutathione + H2O2
?
-
-
-
?
glutathione + hexa 2,4-dienal
?
-
-
-
?
glutathione + hexa-2,4-dienal
?
glutathione + hydrogen peroxide
?
-
-
-
?
glutathione + hydroxyethyldisulfide
?
-
-
-
-
?
glutathione + indomethane
?
glutathione + iodomethane
?
glutathione + linoleic acid hydroperoxide
?
glutathione + methacrolein
?
P46421, Q9C8M3, Q9FUS6, Q9FUS8, Q9FUS9, Q9FUT0, Q9SHH6, Q9SHH7, Q9SHH8, Q9ZRW8, Q9ZW27, Q9ZW28, Q9ZW29 -
-
-
?
glutathione + metolachlor
?
glutathione + microcystin-LR
?
glutathione + naphthalene oxide
?
-
-
-
-
?
glutathione + nitrobutyl chloride
chloride + nitrobutyl-glutathione
-
-
-
?
glutathione + nodularin
?
glutathione + petrilachlor
?
-
-
-
-
?
glutathione + phenethyl isothiocyanate
?
-
129.7% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + phenethyl isothiocyanate
glutathionyl-phenethylthiocarbamate
-
-
-
r
glutathione + phenethyl-isothiocyanate
?
glutathione + pretilachlor
?
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
glutathione + styrene 7,8-oxide
?
glutathione + styrene oxide
?
glutathione + sulfanilamide
?
-
81.8% activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + sulforaphane
?
glutathione + terbuthylazine
?
glutathione + tert-butyl hydroperoxide
?
glutathione + trans,trans-2,4-decadienal
?
-
-
-
-
?
glutathione + trans-2-nonenal
?
glutathione + trans-4-phenyl-3-buten-2-one
?
glutathione + trans-4-phenyl-3-butene-2-one
?
glutathione + trans-6-(2-acetylvinylthio)guanine
?
O15217, O43708, P08263, P09210, P09211, P09488, P28161, P30711, P46439, P78417, Q03013, Q16772 -
-
-
?
glutathione + trans-trans-2,4-decadienal
?
glutathione + trans-trans-2,4-hexadienal
?
-
-
-
-
?
glutathione + trans-trans-2,4-nonadienal
?
-
-
-
-
?
harderoporphyrinogen + glutathione
harderoporphyrinogen-S-glutathione + H2O
-
-
-
-
?
hydrogen peroxide + glutathione
?
Hyp-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
39.5% activity compared to glutathione
-
-
?
iodobutane + glutathione
?
-
-
-
-
?
iodohexane + glutathione
?
-
-
-
-
?
iodomethane + glutathione
?
-
-
-
-
?
maleylacetone + glutathione
?
-
-
-
-
?
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate + glutathione
chloride + L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine
-
-
-
-
?
metolachlor + glutathione
?
-
-
-
-
?
monochlorobimane + glutathione
?
-
-
-
-
?
monochlorobimane + glutathione
bimane-glutathione + HCl
-
-
-
-
?
nitrophenyl acetate + GSH
?
-
6.5% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
NMe-Glu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
3.9% activity compared to glutathione
-
-
?
nonenal + glutathione
?
-
-
-
-
?
pGlu-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
11.5% activity compared to glutathione
-
-
?
phenethyl isothiocyanate + glutathione
?
Pro-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
21.6% activity compared to glutathione
-
-
?
propyl isothiocyanate + glutathione
?
propyl-isothiocyanate + glutathione
?
-
-
-
?
protoporphyrinogen + glutathione
protoporphyrinogen-S-glutathione + H2O
-
-
-
-
?
rac-4-hydroxynonenal + glutathione
S-(4-hydroxy-1-oxononan-3-yl)glutathione
-
elimination of the lipid peroxidation product 4-hydroxynonenal, a toxic compound that contributes to numerous diseases
-
-
?
rac-4-hydroxynonenal + glutathione
S-[(2S)-3-hydoxy-2-(2-oxoethyl)octyl]glutathione
-
GSTA1-1 isoform has poor catalytic efficiency with 4-hydroxynonenal, GSTA4-4 has negligible stereoselectivity towards the two 4-hydroxynonenal enantiomers, despite its high catalytic chemospecificity for alkenals
product binding, overview
-
?
reduced glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
reduced glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
reduced glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
reduced glutathione + 4-nitrophenethyl bromide
?
-
-
-
-
?
reduced glutathione + ethacrynic acid
?
-
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
RX + glutathione
HX + R-S-glutathione
S-(4-nitrophenacyl)-glutathione
4-nitroacetophenone + glutathione
S-glutathionyl-phenylacetophenone + glutathione
?
-
-
-
?
S-glutathionyltetralone + glutathione
?
-
-
-
?
S-phenylacetylglutathione + glutathione
?
-
-
-
?
Sar-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
15.8% activity compared to glutathione
-
-
?
styrene oxide + glutathione
?
sulforaphane + glutathione
?
-
-
-
?
tert-butyl peroxide + glutathione
?
tertiary butyl hydroperoxide + glutathione
?
Tic-Cys-Gly + 1-chloro-2,4-dinitrobenzene
?
41.3% activity compared to glutathione
-
-
?
trans-2-nonenal + glutathione
?
trans-2-nonenal + GSH
?
-
at 1% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
trans-4-phenyl-3-buten-2-one + glutathione
?
-
-
-
-
?
trans-phenyl-butenone + GSH
?
[(methylamino)[methyl(nitroso)amino]methyl]cyanamide + glutathione
[bis(methylamino)methyl]cyanamide + S-nitrosoglutathione
-
transnitrosylation
-
-
?
[3-(4-nitrophenyl)oxiran-2-yl]methanol + glutathione
?
-
-
-
-
?
additional information
?
-
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH

?
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
-
12% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
-
-
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH

?
-
-
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
-
2.3% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
-
-
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH

?
-
-
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
-
4.6% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
-
-
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH

?
-
-
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
-
8% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH

?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
-
at 8% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione

?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione

?
A0A023JBX1, A0A023JBX8, A0A023JCA5, A0A023JCC0, A0A023JCF9, A0A023JCM9, A0A023JCN4, A0A023JCQ9, A0A023JCR5, G7P4V9, G7P5X8, Q2PFL7 -
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)propane + glutathione
?
A0A023JBX5, A0A023JCA8, A0A023JCQ7, A0A023JCR6, F6TP78, F6WWX7, F6Z1G0, F7H5D7, G7N132, G8F1C9, H9Z845, I0FRI5 -
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione

?
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione

S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH

?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
?
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH

S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione

2,4-dinitrobenzyl-glutathione + HCl
residue Ser13 is directly involved in the reaction chemistry and the correct positioning of GSH and CDNB in the ternary catalytic complex. Asn48 and Pro49 have a direct role on the structural integrity of the GSH-binding site (G-site)
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione

?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
A0A023JBX1, A0A023JBX8, A0A023JCA5, A0A023JCC0, A0A023JCF9, A0A023JCM9, A0A023JCN4, A0A023JCQ9, A0A023JCR5, G7P4V9, G7P5X8, Q2PFL7 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
A0A023JBX5, A0A023JCA8, A0A023JCQ7, A0A023JCR6, F6TP78, F6WWX7, F6Z1G0, F7H5D7, G7N132, G8F1C9, H9Z845, I0FRI5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione

S-(2,3-dinitrophenyl)-glutathione + HCl
Tyr119 not only plays a role in hydrophobic substrate binding but also in packing of the active site pocket, which influences chemical interactions involved in enzyme catalysis
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)-glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione

S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
synthetic substrate of GST
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
isoform GST-1 is 18.3times more active than GST-2 and 26.8times more active than GST-3
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
O15217, O43708, O60760, P08263, P09210, P09211, P09488, P0CG30, P21266, P28161, P46439, P78417, Q03013, Q16772, Q7RTV2, Q9H4Y5 -
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
aromatic substitution
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
best substrate
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
isoform GSTU45 shows highest activity with 1-chloro-2,4-dinitrobenzene
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
1-chloro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
best substrate
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH

1-glutathionyl-2,3-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH

?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH

S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH

S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione

S-(2,4-dinitrophenyl)glutathione + HF
-
-
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
-
1-fluoro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
-
?
2,4-dinitro-1-iodobenzene + GSH

S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
-
-
-
-
?
2-hydroxychromene-2-carboxylic acid

trans-o-hydroxybenzylidene pyruvic acid
-
HCCA isomerase catalyzes the glutathione-dependent interconversion of 2-hydroxychromene-2-carboxylic acid and trans-o-hydroxybenzylidene pyruvic acid in the naphthalene catabolic pathway of Pseudomonas putida, mechanisms in the naphthalene catabolic pathwayoverview
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
-
the dimeric protein binds one molecule of GSH very tightly and a second molecule of GSH with much lower affinity, GSH acts as a tightly bound cofactor in the reaction, binding structure, overview
-
-
?
2-hydroxyethyl disulfide + glutathione

?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH

?
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
-
-
-
-
?
4-hydroxynonenal + GSH

?
-
90% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
4-hydroxynonenal + GSH
?
-
10% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
4-nitrobenzyl chloride + glutathione

?
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
-
-
-