EC Explorer
[browse EC tree] - [search]
EC 4.4.1.6 Details
show Brenda entryEC number
4.4.1.6
Accepted name
S-alkylcysteine lyase
Reaction
an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate (overall reaction);;(1a) an S-alkyl-L-cysteine = an alkyl thiol + 2-aminoprop-2-enoate;; (1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);;(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)
Other name(s)
S-alkylcysteinase,
alkylcysteine lyase,
S-alkyl-L-cysteine sulfoxide lyase,
S-alkyl-L-cysteine lyase,
S-alkyl-L-cysteinase,
alkyl cysteine lyase,
S-alkyl-L-cysteine alkylthiol-lyase (deaminating)
Systematic name
S-alkyl-L-cysteine alkyl-thiol-lyase (deaminating; pyruvate-forming)
CAS registry number
62213-27-8
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Possibly identical, in yeast, with EC 4.4.1.8 cystathionine β-lyase.
History
created 1965, deleted 1972, reinstated 1976, deleted 2018
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
4.4.1.7 created 1972, deleted 1976 4.4.1.12 created 1976, deleted 2003 4.4.1.18 created 2000, deleted 2002
