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EC 4.1.99.3 Details

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EC number

4.1.99.3

Accepted name

deoxyribodipyrimidine photo-lyase

Reaction

cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA)

Other name(s)

photoreactivating enzyme, DNA photolyase, DNA-photoreactivating enzyme, DNA cyclobutane dipyrimidine photolyase, DNA photolyase, deoxyribonucleic photolyase, deoxyribodipyrimidine photolyase, photolyase, PRE, PhrB photolyase, deoxyribonucleic cyclobutane dipyrimidine photolyase, phr A photolyase, dipyrimidine photolyase (photosensitive), deoxyribonucleate pyrimidine dimer lyase (photosensitive)

Systematic name

deoxyribocyclobutadipyrimidine pyrimidine-lyase

CAS registry number

37290-70-3

Comment

A flavoprotein (FAD), containing a second chromophore group. The enzyme catalyses the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme.

History

created 1972

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.2 Aldehyde-lyases

4.1.3 Oxo-acid-lyases

4.1.99 Other carbon-carbon lyases

4.1.99.1 tryptophanase

4.1.99.2 tyrosine phenol-lyase

4.1.99.3 deoxyribodipyrimidine photo-lyase

4.1.99.4 created 1981, deleted 2002

4.1.99.5 aldehyde oxygenase (deformylating)

4.1.99.6 created 1989, deleted 2000

4.1.99.7 created 1992 as EC 2.5.1.40, transferred 1999 to EC 4.1.99.7, deleted 2000

4.1.99.8 created 2000, deleted 2000

4.1.99.9 created 2000, deleted 2000

4.1.99.10 created 2000, deleted 2000

4.1.99.11 benzylsuccinate synthase

4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase

4.1.99.13 (6-4)DNA photolyase

4.1.99.14 spore photoproduct lyase

4.1.99.15 S-specific spore photoproduct lyase

4.1.99.16 geosmin synthase

4.1.99.17 phosphomethylpyrimidine synthase

4.1.99.18 cyclic pyranopterin phosphate synthase

4.1.99.19 2-iminoacetate synthase

4.1.99.20 3-amino-4-hydroxybenzoate synthase

4.1.99.21 (5-formylfuran-3-yl)methyl phosphate synthase

4.1.99.22 GTP 3′,8-cyclase

4.1.99.23 5-hydroxybenzimidazole synthase

4.1.99.24 L-tyrosine isonitrile synthase

4.1.99.25 L-tryptophan isonitrile synthase

4.1.99.26 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase

4.2 Carbon-oxygen lyases

4.3 Carbon-nitrogen lyases

4.4 Carbon-sulfur lyases

4.5 Carbon-halide lyases

4.6 Phosphorus-oxygen lyases

4.7 carbon-phosphorus lyases

4.8 Nitrogen-oxygen lyases

4.98 ATP-independent chelatases

4.99 Other lyases

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Release 2023.1 (January 2023)