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EC 1.13.11.11 Details
show Brenda entryEC number
1.13.11.11
Accepted name
tryptophan 2,3-dioxygenase
Reaction
L-tryptophan + O2 = N-formyl-L-kynurenine
Other name(s)
tryptophan pyrrolase (ambiguous),
tryptophanase,
tryptophan oxygenase,
tryptamine 2,3-dioxygenase,
tryptophan peroxidase,
indoleamine 2,3-dioxygenase (ambiguous),
indolamine 2,3-dioxygenase (ambiguous),
L-tryptophan pyrrolase,
TDO,
L-tryptophan 2,3-dioxygenase,
L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Systematic name
L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
CAS registry number
9014-51-1
Comment
A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2].
History
created 1961 as EC 1.11.1.4, deleted 1964, reinstated 1965 as EC 1.13.1.12, transferred 1972 to EC 1.13.11.11, modified 1989, modified 2006
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.2.1 created 1961, deleted 1965 1.6.2.3 created 1972, deleted 1965 1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002 1.13.11.21 created 1972, deleted 2001
