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EC 6.4.1.7 Details

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EC number

6.4.1.7

Accepted name

2-oxoglutarate carboxylase

Reaction

ATP + 2-oxoglutarate + HCO₃^- = ADP + phosphate + oxalosuccinate

Other name(s)

oxalosuccinate synthetase, carboxylating factor for ICDH (incorrect), CFI, OGC

CAS registry number

60382-75-4

Comment

A biotin-containing enzyme that requires Mg²⁺ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD⁺), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2].

History

created 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.3 Forming carbon-nitrogen bonds

6.4 Forming carbon-carbon bonds

6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

6.4.1.1 pyruvate carboxylase

6.4.1.2 acetyl-CoA carboxylase

6.4.1.3 propionyl-CoA carboxylase

6.4.1.4 methylcrotonoyl-CoA carboxylase

6.4.1.5 geranoyl-CoA carboxylase

6.4.1.6 acetone carboxylase

6.4.1.7 2-oxoglutarate carboxylase

6.4.1.8 acetophenone carboxylase

6.4.1.9 coenzyme F₄₃₀ synthetase

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

7 Translocases