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EC 6.4.1.2 Details

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EC number

6.4.1.2

Accepted name

acetyl-CoA carboxylase

Reaction

ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA

Other name(s)

HFA1 (gene name), ACC1 (gene name), acetyl coenzyme A carboxylase, acetyl-CoA:carbon-dioxide ligase (ADP-forming)

Systematic name

acetyl-CoA:hydrogencarbonate ligase (ADP-forming)

CAS registry number

9023-93-2

Comment

This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.

History

created 1961, modified 2018

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.3 Forming carbon-nitrogen bonds

6.4 Forming carbon-carbon bonds

6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

6.4.1.1 pyruvate carboxylase

6.4.1.2 acetyl-CoA carboxylase

6.4.1.3 propionyl-CoA carboxylase

6.4.1.4 methylcrotonoyl-CoA carboxylase

6.4.1.5 geranoyl-CoA carboxylase

6.4.1.6 acetone carboxylase

6.4.1.7 2-oxoglutarate carboxylase

6.4.1.8 acetophenone carboxylase

6.4.1.9 coenzyme F₄₃₀ synthetase

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

7 Translocases