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Information on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.41
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IUBMB Comments
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm . The enzyme from some species can also use NADP+ but much more slowly .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
isocitrate dehydrogenase, isocitric dehydrogenase, isocitrate dehydrogenase 2, nad-dependent isocitrate dehydrogenase, nad-idh, nad-isocitrate dehydrogenase, nad-icdh, idh3a, nad+-dependent isocitrate dehydrogenase, nad-linked isocitrate dehydrogenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH
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