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EC 1.8.1.5 Details
show Brenda entryEC number
1.8.1.5
Accepted name
2-oxopropyl-CoM reductase (carboxylating)
Reaction
CoM + acetoacetate + NADP+ = 2-oxopropyl-CoM + CO2 + NADPH
Other name(s)
NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase,
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase,
2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)
Systematic name
2-sulfanylethane-1-sulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)
CAS registry number
244301-63-1
Comment
Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-sulfanylethane-1-sulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV].html">click here that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
History
created 2001
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2.3.2 created 1961, deleted 1984 1.2.3.10 created 1990, deleted 2003 1.2.3.12 created 2000, deleted 2003 1.8.1.1 created 1961, deleted 1972
