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EC 1.8.1.2 Details
show Brenda entryEC number
1.8.1.2
Accepted name
assimilatory sulfite reductase (NADPH)
Reaction
hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+
Other name(s)
sulfite reductase (NADPH),
sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase,
NADPH-sulfite reductase,
NADPH-dependent sulfite reductase,
H2S-NADP oxidoreductase,
sulfite reductase (NADPH2),
MET5 (gene name),
MET10 (gene name),
cysI (gene name),
cysJ (gene name)
Systematic name
hydrogen-sulfide:NADP+ oxidoreductase
CAS registry number
9029-35-0
Comment
Contains siroheme, [4Fe-4S] cluster, FAD and FMN. The enzyme, which catalyses the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. Different from EC 1.8.99.5, dissimilatory sulfite reductase, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin).
History
created 1961, modified 2015
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2.3.2 created 1961, deleted 1984 1.2.3.10 created 1990, deleted 2003 1.2.3.12 created 2000, deleted 2003 1.8.1.1 created 1961, deleted 1972
