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EC 6.3.4.24 Details
EC number
6.3.4.24
Accepted name
tyramine—L-glutamate ligase
Reaction
ATP + tyramine + L-glutamate = ADP + phosphate + γ-glutamyltyramine
Other name(s)
mfnD (gene name)
Systematic name
tyramine:L-glutamate γ-ligase (ADP-forming)
Comment
The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+.
History
created 2014
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.2 With a cytochrome as acceptor
1.2.3 With oxygen as acceptor
1.2.4 With a disulfide as acceptor
1.2.5 With a quinone or similar compound as acceptor
1.2.7 With an iron-sulfur protein as acceptor
1.2.98 With other, known, physiological acceptors
1.2.99 With unknown physiological acceptors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.98 Enzymes using H2 as reductant (deleted subclass)
1.98.1. undefined
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
6.3.2 Acid—amino-acid ligases (peptide synthases)
6.3.3 Cyclo-ligases
6.3.4 Other carbon-nitrogen ligases
6.3.4.1 GMP synthase
6.3.4.2 CTP synthase (glutamine hydrolysing)
6.3.4.3 formate—tetrahydrofolate ligase
6.3.4.4 adenylosuccinate synthase
6.3.4.5 argininosuccinate synthase
6.3.4.6 urea carboxylase
6.3.4.7 ribose-5-phosphate—ammonia ligase
6.3.4.8 imidazoleacetate—phosphoribosyldiphosphate ligase
6.3.4.9 biotin—[methylmalonyl-CoA-carboxytransferase] ligase
6.3.4.10 biotin—[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
6.3.4.11 biotin—[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.12 glutamate—methylamine ligase
6.3.4.13 phosphoribosylamine—glycine ligase
6.3.4.14 biotin carboxylase
6.3.4.15 biotin—[biotin carboxyl-carrier protein] ligase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.4.17 formate—dihydrofolate ligase
6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase
6.3.4.19 tRNAIle-lysidine synthase
6.3.4.20 7-cyano-7-deazaguanine synthase
6.3.4.21 nicotinate phosphoribosyltransferase
6.3.4.22 tRNAIle2-agmatinylcytidine synthase
6.3.4.23 formate—phosphoribosylaminoimidazolecarboxamide ligase
6.3.4.24 tyramine—L-glutamate ligase
6.3.4.25 2-amino-2′-deoxyadenylo-succinate synthase
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases