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EC 6.3.4.19 Details
EC number
6.3.4.19
Accepted name
tRNAIle-lysidine synthase
Reaction
[tRNAIle2]-cytidine34 + L-lysine + ATP = [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O
Other name(s)
TilS,
mesJ (gene name),
yacA (gene name),
isoleucine-specific transfer ribonucleate lysidine synthetase,
tRNAIle-lysidine synthetase
Systematic name
L-lysine:[tRNAIle2]-cytidine34 ligase (AMP-forming)
CAS registry number
635304-92-6
Comment
The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle.
History
created 2011
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