EC Explorer

1.6.3.5

renalase

(1) 1,2-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂;;(2) 1,6-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂

αNAD(P)H oxidase/anomerase (incorrect), NAD(P)H:oxygen oxidoreductase (H₂O₂-forming, epimerising) (incorrect)

dihydro-NAD(P):oxygen oxidoreductase (H₂O₂-forming)

Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)⁺. These isomeric forms, generated by nonspecific reduction of β-NAD(P)⁺ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

created 2014, modified 2015