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BRENDA support

Information on EC 1.6.3.5 - renalase

for references in articles please use BRENDA:EC1.6.3.5

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IUBMB Comments

Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)+. These isomeric forms, generated by nonspecific reduction of β-NAD(P)+ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
renalase, ren-2, ren-1, renalase-1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2
show the reaction diagram
(1)
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1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2
show the reaction diagram
(2)
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