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Information on EC 1.6.3.5 - renalase

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EC Tree

1 Oxidoreductases

1.6 Acting on NADH or NADPH

1.6.3 With oxygen as acceptor

1.6.3.5 renalase

IUBMB Comments

Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

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