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Literature summary for 1.6.3.5 extracted from

  • Wang, Y.; Safirstein, R.; Velazquez, H.; Guo, X.J.; Hollander, L.; Chang, J.; Chen, T.M.; Mu, J.J.; Desir, G.V.
    Extracellular renalase protects cells and organs by outside-in signalling (2017), J. Cell. Mol. Med., 21, 1260-1265 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.5

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens renalase expression is significantly increased in cancers of the pancreas, bladder and breast and in melanoma up

General Information

General Information Comment Organism
malfunction dysregulated extracellular renalase signalling promotes tumour growth Homo sapiens
physiological function administration of renalase lowers blood pressure and heart rate and also protects cells and organs against ischaemic and toxic injury. Independent of its enzymatic properties, renalase functions as a cytokine that provides protection to cells, tissues and organs by interacting with its receptor to activate protein kinase B, JAK/STAT, and the mitogen-activated protein kinase pathways. Extracellular renalase protects against renal injury, cardiac injury, and acute pancreatitis Homo sapiens