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EC 3.5.2.18 Details

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EC number

3.5.2.18

Accepted name

enamidase

Reaction

6-oxo-1,4,5,6-tetrahydronicotinate + 2 H₂O = 2-formylglutarate + NH₃

Systematic name

6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase

Comment

Contains iron and Zn²⁺. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Δ-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).

History

created 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.98.1. undefined

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.2 In cyclic amides

3.5.2.1 barbiturase

3.5.2.2 dihydropyrimidinase

3.5.2.3 dihydroorotase

3.5.2.4 carboxymethylhydantoinase

3.5.2.5 allantoinase

3.5.2.6 β-lactamase

3.5.2.7 imidazolonepropionase

3.5.2.8 created 1972, deleted 1978

3.5.2.9 5-oxoprolinase (ATP-hydrolysing)

3.5.2.10 creatininase

3.5.2.11 L-lysine-lactamase

3.5.2.12 6-aminohexanoate-cyclic-dimer hydrolase

3.5.2.13 2,5-dioxopiperazine hydrolase

3.5.2.14 N-methylhydantoinase (ATP-hydrolysing)

3.5.2.15 cyanuric acid amidohydrolase

3.5.2.16 maleimide hydrolase

3.5.2.17 hydroxyisourate hydrolase

3.5.2.18 enamidase

3.5.2.19 streptothricin hydrolase

3.5.2.20 isatin hydrolase

3.5.3 In linear amidines

3.5.4 In cyclic amidines

3.5.5 In nitriles

3.5.99 In other compounds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

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Release 2023.1 (January 2023)