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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
6-hydroxynicotinic reductase, 6-oxotetrahydronicotinate dehydrogenase, HNA reductase, reductase, 6-hydroxynicotinate,
more
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6-hydroxynicotinic reductase
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6-oxotetrahydronicotinate dehydrogenase
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reductase, 6-hydroxynicotinate
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6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
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6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
6-hydroxynicotinate + reduced ferredoxin
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
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r
6-hydroxynicotinate + reduced ferredoxin
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin
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r
6-hydroxynicotinate + reduced methyl viologen
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized methyl viologen
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r
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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overview of nicotinate catabolism pathway
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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oxidized methyl viologen is also substrate
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r
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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CoA
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
Ferredoxin
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reduced or oxidized, as electron carrier
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Fe2+
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one (2Fe-2S)2+/1+ and two (4Fe-4S)2+/1+ clusters
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arsenate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
phosphate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
pyruvate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
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0.016
reduced ferredoxin
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0.3
reduced methyl viologen
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350
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purified enzyme under strictly anaerobic conditions
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5.5 - 8.2
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pH 5.5: about 60% of activity maximum, pH 8.2: about 20% of activity maximum, rapid decline in activity below pH 5.6 may be partly due to destruction of ferredoxin in acid
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brenda
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brenda
strain DSMZ 1223
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brenda
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HNR_EUBBA
499
0
53097
Swiss-Prot
-
A0A346B6T1_9BURK
543
0
57540
TrEMBL
-
A1WG75_VEREI
Verminephrobacter eiseniae (strain EF01-2)
550
0
57578
TrEMBL
-
A0A6P2E1Y7_9BURK
535
0
57193
TrEMBL
-
A0A2P9AB05_9RHIZ
513
0
54569
TrEMBL
-
A0A177H758_9RHOB
494
0
53279
TrEMBL
-
A0A4Y7REU4_9FIRM
498
0
52960
TrEMBL
-
A0A5P9I582_9RHOB
479
0
51027
TrEMBL
-
A0A1M5Y3S7_9VIBR
88
0
10143
TrEMBL
-
A0A1U7MD00_9FIRM
526
0
57058
TrEMBL
-
A0A1C5ZWD5_9FIRM
uncultured Flavonifractor sp
503
0
53349
TrEMBL
-
A0A418SJA9_9RHOB
491
0
51540
TrEMBL
-
A0A0P1FFN4_THAGE
496
0
53336
TrEMBL
-
A0A2J7W652_9BURK
535
0
57336
TrEMBL
-
A0A0U1KYL2_9FIRM
507
0
53426
TrEMBL
-
A0A6I5ZNL2_9THEO
503
0
53592
TrEMBL
-
A0A517DYR0_9FIRM
500
0
51504
TrEMBL
-
B1G0W8_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
530
0
56359
TrEMBL
-
A0A2Z2NRJ9_9GAMM
527
0
56846
TrEMBL
-
A0A6J4Y0W7_9DELT
502
0
54119
TrEMBL
-
A0A0D5N3E0_GEOSN
83
0
9579
TrEMBL
-
F4LUP8_TEPAE
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
504
0
54379
TrEMBL
-
A0A259UPE0_9FIRM
502
0
52710
TrEMBL
-
A0A6P2DYN6_9BURK
535
0
57314
TrEMBL
-
A0A644VYA7_9ZZZZ
546
0
57829
TrEMBL
other Location (Reliability: 2 )
A0A174RH83_9FIRM
501
0
52849
TrEMBL
-
A0A1Y5RMN8_9RHOB
483
0
51450
TrEMBL
-
A0A1C6AFU5_9FIRM
uncultured Roseburia sp
81
0
9465
TrEMBL
-
A0A6J5K2J3_9BURK
531
0
56312
TrEMBL
-
A0A508TZH2_9BRAD
482
0
51296
TrEMBL
-
A0A0K0Y2I8_9RHOB
497
0
53607
TrEMBL
-
A0A2H6B0K1_9BACT
511
0
54719
TrEMBL
-
A0A6J4ZQ33_9BURK
531
0
56258
TrEMBL
-
Q124T1_POLSJ
Polaromonas sp. (strain JS666 / ATCC BAA-500)
526
0
56261
TrEMBL
-
A0A1R3V6J3_9RHIZ
513
0
54522
TrEMBL
-
A0A0P7XP77_9RHOB
506
0
54917
TrEMBL
-
A0A212M139_9FIRM
uncultured Sporomusa sp
526
0
57064
TrEMBL
-
A0A2C9DE68_9RHIZ
489
0
51915
TrEMBL
-
A0A0J9EEG2_9RHOB
495
0
52707
TrEMBL
-
A0A679IXU1_VARPD
535
0
56999
TrEMBL
-
Q13KU0_PARXL
Paraburkholderia xenovorans (strain LB400)
543
0
57687
TrEMBL
-
A0A2S6QD27_9PROT
510
0
54701
TrEMBL
-
A0A1V5CXS9_9DELT
269
0
29244
TrEMBL
-
A0A564WI63_9PROT
492
0
52606
TrEMBL
-
A5EEJ8_BRASB
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
482
0
51139
TrEMBL
-
A0A259UEL7_9FIRM
357
0
38820
TrEMBL
-
A0A2A2HCP5_9EURY
65
0
7561
TrEMBL
-
A0A1X6YLK3_9RHOB
484
0
51439
TrEMBL
-
A0A0J5QIX0_9RHOB
497
0
53492
TrEMBL
-
A0A2S6TEZ8_9PROT
507
0
54600
TrEMBL
-
E3H6M2_ILYPC
Ilyobacter polytropus (strain ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1)
505
0
54326
TrEMBL
-
A0A0P7W0X6_9RHOB
492
0
52999
TrEMBL
-
A0A5P9FA34_9RHOB
477
0
50337
TrEMBL
-
A0A2R8B776_9RHOB
481
0
51660
TrEMBL
-
A0A2X0WNP5_9GAMM
69
0
7500
TrEMBL
-
A0A6P2E8L4_9BURK
535
0
57321
TrEMBL
-
A0A1Y5SGS5_9PROT
492
0
52201
TrEMBL
-
A0A1L9NTU4_9RHOB
493
0
53095
TrEMBL
-
A0A1V4W746_9DELT
508
0
55263
TrEMBL
-
A0A7U9SI63_9FIRM
584
0
63763
TrEMBL
-
A0A2R8CA33_9RHOB
495
0
53098
TrEMBL
-
A0A3B0SSY3_9ZZZZ
340
0
36526
TrEMBL
other Location (Reliability: 3 )
A0A5Q4YYH2_9BURK
571
0
60431
TrEMBL
-
A0A2U3L9S6_9DELT
509
0
54247
TrEMBL
-
A0A1X6Y556_9RHOB
497
0
52562
TrEMBL
-
A0A1V6C270_9DELT
508
0
55307
TrEMBL
-
A0A1J5JTB4_MOOTH
503
0
53358
TrEMBL
-
A0A1U7D7U0_9RHOB
503
0
53938
TrEMBL
-
A0A259ULA6_9FIRM
507
0
53446
TrEMBL
-
A0A1V4WRW7_9DELT
507
0
54922
TrEMBL
-
A0A1V5BXW1_9DELT
248
0
26666
TrEMBL
-
A0A5P3A5W8_9RHOB
513
0
54032
TrEMBL
-
A0A6J4WU83_9DELT
502
0
53592
TrEMBL
-
A0A1M7Z2V3_9VIBR
88
0
10181
TrEMBL
-
A0A6J5GEL1_9BURK
534
0
56545
TrEMBL
-
A0A0H3IZD2_CLOPA
503
0
53969
TrEMBL
-
A0A0H2M7A6_VARPD
538
0
57469
TrEMBL
-
A0A221K7H2_9RHOB
529
0
56403
TrEMBL
-
A0A0T5PE28_9RHOB
486
0
52044
TrEMBL
-
A0A653MLK0_9BRAD
494
0
52685
TrEMBL
-
A0A0B4XHM3_9RHIZ
497
0
52992
TrEMBL
other Location (Reliability: 1 )
A0A380WFS9_AMIAI
511
0
54342
TrEMBL
-
A0A6P2DYS2_9BURK
535
0
57212
TrEMBL
-
A0A2S6U1X4_9PROT
401
0
42449
TrEMBL
-
A0A1L5PGT9_RHIET
497
0
53311
TrEMBL
-
Q2IZI5_RHOP2
Rhodopseudomonas palustris (strain HaA2)
498
0
52840
TrEMBL
-
A0A238JRH8_9RHOB
499
0
53587
TrEMBL
-
A0A2U3Q434_9BRAD
485
0
51705
TrEMBL
-
A0A2S0XD84_9RHIZ
511
0
54392
TrEMBL
-
A0A161YKI4_9CLOT
505
0
54334
TrEMBL
-
A0A6J5C8X6_9BURK
538
0
57037
TrEMBL
-
A0A1Y5RY24_9RHOB
495
0
53204
TrEMBL
-
A0A1P8V044_9RHOB
503
0
53761
TrEMBL
-
A0A6J4ZXD4_9BURK
535
0
56798
TrEMBL
-
A0A5P9H743_9RHOB
479
0
50951
TrEMBL
-
A0A380TFK1_9ZZZZ
492
0
52576
TrEMBL
other Location (Reliability: 1 )
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additional information
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391150
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5
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stable in liquid nitrogen, unstable in air
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cobinamide cyanide, 0.01 mM, accelerates loss of activity in air
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ethylene glycol high concentrations stabilize
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glycerol, concentrations above 30% stabilize
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Na2S * 9 H2O stabilizes, maximal effect at 0.03%
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stable to freezing and thawing
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air, 5°C, 24 h, 50% loss of activity
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391150
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several months in liquid nitrogen and up to 50 h with argon
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under strictly anaerobic conditions
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Holcenberg, J.S.; Tsai, L.
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid
J. Biol. Chem.
244
1204-1211
1969
Clostridium sp.
brenda
Kitts, C.L.; Lapointe, J.P.; Lam, V.T.; Ludwig, R.A.
Elucidation of the complete Azorhizobium nicotinate catabolism pathway
J. Bacteriol.
174
7791-7797
1992
Azorhizobium caulinodans
brenda
Alhapel, A.; Darley, D.J.; Wagener, N.; Eckel, E.; Elsner, N.; Pierik, A.J.
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri
Proc. Natl. Acad. Sci. USA
103
12341-12346
2006
Eubacterium barkeri
brenda
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