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Information on EC 1.3.7.1 - 6-hydroxynicotinate reductase
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1.3.7.1 6-hydroxynicotinate reductaseSpecify your search results
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
Synonyms
6-hydroxynicotinic reductase, 6-oxotetrahydronicotinate dehydrogenase, HNA reductase, reductase, 6-hydroxynicotinate, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PATHWAY SOURCE
PATHWAYS
MetaCyc
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SYSTEMATIC NAME
IUBMB Comments
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9030-84-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
6-hydroxynicotinate + reduced ferredoxin
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
-
-
-
-
r
6-hydroxynicotinate + reduced ferredoxin
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin
-
-
-
-
r
6-hydroxynicotinate + reduced methyl viologen
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized methyl viologen
-
-
-
-
r
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
-
-
-
?
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
-
overview of nicotinate catabolism pathway
-
?
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
-
oxidized methyl viologen is also substrate
-
r
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
CoA
-
crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
arsenate
-
crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
phosphate
-
crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
pyruvate
-
crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.5 - 8.2
-
pH 5.5: about 60% of activity maximum, pH 8.2: about 20% of activity maximum, rapid decline in activity below pH 5.6 may be partly due to destruction of ferredoxin in acid
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). F4LUP8_TEPAE
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
504
0
54379
TrEMBL
-
A0A2S6TEZ8_9PROT
507
0
54600
TrEMBL
-
A0A2S6QD27_9PROT
510
0
54701
TrEMBL
-
A0A418SJA9_9RHOB
491
0
51540
TrEMBL
-
A1WG75_VEREI
Verminephrobacter eiseniae (strain EF01-2)
550
0
57578
TrEMBL
-
A5EEJ8_BRASB
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
482
0
51139
TrEMBL
-
A0A3B0SSY3_9ZZZZ
340
0
36526
TrEMBL
other Location (Reliability: 3)
A0A1V5CXS9_9DELT
269
0
29244
TrEMBL
-
Q13KU0_PARXL
Paraburkholderia xenovorans (strain LB400)
543
0
57687
TrEMBL
-
A0A6J5K2J3_9BURK
531
0
56312
TrEMBL
-
A0A2S6U1X4_9PROT
401
0
42449
TrEMBL
-
A0A0P7XP77_9RHOB
506
0
54917
TrEMBL
-
A0A1V4W746_9DELT
508
0
55263
TrEMBL
-
A0A1V4WRW7_9DELT
507
0
54922
TrEMBL
-
A0A0J5QIX0_9RHOB
497
0
53492
TrEMBL
-
A0A2Z2NRJ9_9GAMM
527
0
56846
TrEMBL
-
A0A0J9EEG2_9RHOB
495
0
52707
TrEMBL
-
A0A0H3IZD2_CLOPA
503
0
53969
TrEMBL
-
A0A221K7H2_9RHOB
529
0
56403
TrEMBL
-
A0A1V5BXW1_9DELT
248
0
26666
TrEMBL
-
A0A0P7W0X6_9RHOB
492
0
52999
TrEMBL
-
A0A1U7MD00_9FIRM
526
0
57058
TrEMBL
-
A0A2C9DE68_9RHIZ
489
0
51915
TrEMBL
-
A0A6J4ZQ33_9BURK
531
0
56258
TrEMBL
-
A0A380TFK1_9ZZZZ
492
0
52576
TrEMBL
other Location (Reliability: 1)
B1G0W8_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
530
0
56359
TrEMBL
-
A0A564WI63_9PROT
492
0
52606
TrEMBL
-
E3H6M2_ILYPC
Ilyobacter polytropus (strain ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1)
505
0
54326
TrEMBL
-
A0A0B4XHM3_9RHIZ
497
0
52992
TrEMBL
-
A0A1V6C270_9DELT
508
0
55307
TrEMBL
-
A0A259UEL7_9FIRM
357
0
38820
TrEMBL
-
A0A346B6T1_9BURK
543
0
57540
TrEMBL
-
A0A177H758_9RHOB
494
0
53279
TrEMBL
-
A0A259ULA6_9FIRM
507
0
53446
TrEMBL
-
Q2IZI5_RHOP2
Rhodopseudomonas palustris (strain HaA2)
498
0
52840
TrEMBL
-
A0A6J4Y0W7_9DELT
502
0
54119
TrEMBL
-
A0A644VYA7_9ZZZZ
546
0
57829
TrEMBL
other Location (Reliability: 2)
A0A6J4WU83_9DELT
502
0
53592
TrEMBL
-
A0A259UPE0_9FIRM
502
0
52710
TrEMBL
-
Q124T1_POLSJ
Polaromonas sp. (strain JS666 / ATCC BAA-500)
526
0
56261
TrEMBL
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holcenberg, J.S.; Tsai, L.
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid
J. Biol. Chem.
244
1204-1211
1969
Clostridium sp.
brenda
Kitts, C.L.; Lapointe, J.P.; Lam, V.T.; Ludwig, R.A.
Elucidation of the complete Azorhizobium nicotinate catabolism pathway
J. Bacteriol.
174
7791-7797
1992
Azorhizobium caulinodans
brenda
Alhapel, A.; Darley, D.J.; Wagener, N.; Eckel, E.; Elsner, N.; Pierik, A.J.
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri
Proc. Natl. Acad. Sci. USA
103
12341-12346
2006
Eubacterium barkeri
brenda
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