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Information on EC 1.3.7.1 - 6-hydroxynicotinate reductase for references in articles please use BRENDA:EC1.3.7.1
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
6-hydroxynicotinic reductase, 6-oxotetrahydronicotinate dehydrogenase, HNA reductase, reductase, 6-hydroxynicotinate,
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6-hydroxynicotinic reductase
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6-oxotetrahydronicotinate dehydrogenase
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reductase, 6-hydroxynicotinate
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6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin
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6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
6-hydroxynicotinate + reduced ferredoxin
1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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overview of nicotinate catabolism pathway
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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oxidized methyl viologen is also substrate
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1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin
6-hydroxynicotinate + reduced ferredoxin
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CoA
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
Ferredoxin
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reduced or oxidized, as electron carrier
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Fe2+
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one (2Fe-2S)2+/1+ and two (4Fe-4S)2+/1+ clusters
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arsenate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
phosphate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
pyruvate
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crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
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350
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purified enzyme under strictly anaerobic conditions
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5.5 - 8.2
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pH 5.5: about 60% of activity maximum, pH 8.2: about 20% of activity maximum, rapid decline in activity below pH 5.6 may be partly due to destruction of ferredoxin in acid
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brenda
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brenda
strain DSMZ 1223
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brenda
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HNR_EUBBA
499
0
53097
Swiss-Prot
A0A174RH83_9FIRM
501
0
52849
TrEMBL
A0A2R8CA33_9RHOB
495
0
53098
TrEMBL
A0A1L5PGT9_RHIET
497
0
53311
TrEMBL
A0A1L9NTU4_9RHOB
493
0
53095
TrEMBL
A0A2S0XD84_9RHIZ
511
0
54392
TrEMBL
A0A1P8V044_9RHOB
503
0
53761
TrEMBL
A0A0H3IZD2_CLOPA
503
0
53969
TrEMBL
A0A2U3Q434_9BRAD
485
0
51705
TrEMBL
A0A0B4XHM3_9RHIZ
497
0
52992
TrEMBL
A0A0U1KYL2_9FIRM
507
0
53426
TrEMBL
A0A238JRH8_9RHOB
499
0
53587
TrEMBL
A0A1X6Y556_9RHOB
497
0
52562
TrEMBL
A0A2Z2NRJ9_9GAMM
527
0
56846
TrEMBL
A0A2U3L9S6_9DELT
509
0
54247
TrEMBL
A0A2S6U1X4_9PROT
401
0
42449
TrEMBL
A0A1U7D7U0_9RHOB
503
0
53938
TrEMBL
A0A259UEL7_9FIRM
357
0
38820
TrEMBL
A0A0H2M7A6_VARPD
538
0
57469
TrEMBL
Q2IZI5_RHOP2
Rhodopseudomonas palustris (strain HaA2)
498
0
52840
TrEMBL
A0A3P5WPT8_9ZZZZ
492
0
52606
TrEMBL
A0A380WFS9_AMIAI
511
0
54342
TrEMBL
A0A1Y5SGS5_9PROT
492
0
52201
TrEMBL
A0A0P7XP77_9RHOB
506
0
54917
TrEMBL
A0A161YKI4_9CLOT
505
0
54334
TrEMBL
A0A259ULA6_9FIRM
507
0
53446
TrEMBL
A0A3B0SSY3_9ZZZZ
340
0
36526
TrEMBL
A0A2S6TEZ8_9PROT
507
0
54600
TrEMBL
A0A1V4W746_9DELT
508
0
55263
TrEMBL
A0A1V4WRW7_9DELT
507
0
54922
TrEMBL
A0A380TFK1_9ZZZZ
492
0
52576
TrEMBL
A0A0J5QIX0_9RHOB
497
0
53492
TrEMBL
A0A221K7H2_9RHOB
529
0
56403
TrEMBL
A0A1V5BXW1_9DELT
248
0
26666
TrEMBL
A0A2R8B776_9RHOB
481
0
51660
TrEMBL
A0A2H6B0K1_9BACT
511
0
54719
TrEMBL
A0A2P9AB05_9RHIZ
513
0
54569
TrEMBL
A0A2A2HCP5_9EURY
65
0
7561
TrEMBL
A0A0D5N3E0_GEOSN
83
0
9579
TrEMBL
A0A1U7MD00_9FIRM
526
0
57058
TrEMBL
A0A212M139_9FIRM
uncultured Sporomusa sp
526
0
57064
TrEMBL
A0A1M7Z2V3_9VIBR
88
0
10181
TrEMBL
A0A2C9DE68_9RHIZ
489
0
51915
TrEMBL
A0A1J5JTB4_MOOTH
503
0
53358
TrEMBL
A0A259UPE0_9FIRM
502
0
52710
TrEMBL
F4LUP8_TEPAE
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
504
0
54379
TrEMBL
A1WG75_VEREI
Verminephrobacter eiseniae (strain EF01-2)
550
0
57578
TrEMBL
A0A2J7W652_9BURK
535
0
57336
TrEMBL
A0A1R3V6J3_9RHIZ
513
0
54522
TrEMBL
A0A2Z6I633_9RHIZ
496
0
52479
TrEMBL
A0A1M5Y3S7_9VIBR
88
0
10143
TrEMBL
Q13KU0_PARXL
Paraburkholderia xenovorans (strain LB400)
543
0
57687
TrEMBL
E3H6M2_ILYPC
Ilyobacter polytropus (strain DSM 2926 / CuHBu1)
505
0
54326
TrEMBL
A0A0K0Y2I8_9RHOB
497
0
53607
TrEMBL
A0A1C6AFU5_9FIRM
uncultured Roseburia sp
81
0
9465
TrEMBL
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additional information
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391150
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5
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stable in liquid nitrogen, unstable in air
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cobinamide cyanide, 0.01 mM, accelerates loss of activity in air
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ethylene glycol high concentrations stabilize
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glycerol, concentrations above 30% stabilize
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Na2S * 9 H2O stabilizes, maximal effect at 0.03%
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stable to freezing and thawing
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air, 5°C, 24 h, 50% loss of activity
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391150
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several months in liquid nitrogen and up to 50 h with argon
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under strictly anaerobic conditions
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Holcenberg, J.S.; Tsai, L.
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid
J. Biol. Chem.
244
1204-1211
1969
Clostridium sp.
brenda
Kitts, C.L.; Lapointe, J.P.; Lam, V.T.; Ludwig, R.A.
Elucidation of the complete Azorhizobium nicotinate catabolism pathway
J. Bacteriol.
174
7791-7797
1992
Azorhizobium caulinodans
brenda
Alhapel, A.; Darley, D.J.; Wagener, N.; Eckel, E.; Elsner, N.; Pierik, A.J.
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri
Proc. Natl. Acad. Sci. USA
103
12341-12346
2006
Eubacterium barkeri
brenda
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