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EC 3.2.2.29 Details
EC number
3.2.2.29
Accepted name
thymine-DNA glycosylase
Reaction
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Other name(s)
mismatch-specific thymine-DNA glycosylase,
mismatch-specific thymine-DNA N-glycosylase,
hTDG,
hsTDG,
TDG,
thymine DNA glycosylase,
G/T glycosylase,
uracil/thymine DNA glycosylase,
T:G mismatch-specific thymidine-DNA glycosylase,
G:T mismatch-specific thymine DNA-glycosylase
Systematic name
thymine-DNA deoxyribohydrolase (thymine-releasing)
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5′-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
created 2009
EC Tree
3.2.2.18 created 1984, deleted 1989