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EC 3.2.2.14 Details
EC number
3.2.2.14
Accepted name
NMN nucleosidase
Reaction
β-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide
Other name(s)
NMNase, nicotinamide mononucleotide nucleosidase, nicotinamide mononucleotidase, NMN glycohydrolase, NMNGhase
Systematic name
nicotinamide-nucleotide phosphoribohydrolase
CAS registry number
37237-49-3
Comment
The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
created 1976, modified 2018
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.2 With a cytochrome as acceptor
1.3.3 With oxygen as acceptor
1.3.4 With a disulfide as acceptor
1.3.5 With a quinone or related compound as acceptor
1.3.7 With an iron-sulfur protein as acceptor
1.3.8 With a flavin as acceptor
1.3.98 With other, known, physiological acceptors
1.3.99 With unknown physiological acceptors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.10.1 With NAD+ or NADP+ as acceptor
1.10.2 With a cytochrome as acceptor
1.10.3 With oxygen as acceptor
1.10.5 With a quinone or related compound as acceptor
1.10.9 With a copper protein as acceptor
1.10.99 With unknown physiological acceptors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.15.1 Acting on superoxide as acceptor (only sub-subclass identified to date)
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.2 Hydrolysing N-glycosyl compounds
3.2.2.1 purine nucleosidase
3.2.2.2 inosine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.4 AMP nucleosidase
3.2.2.5 NAD+ glycohydrolase
3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase
3.2.2.10 pyrimidine-5′-nucleotide nucleosidase
3.2.2.11 β-aspartyl-N-acetylglucosaminidase
3.2.2.12 inosinate nucleosidase
3.2.2.13 1-methyladenosine nucleosidase
3.2.2.14 NMN nucleosidase
3.2.2.15 DNA-deoxyinosine glycosylase
3.2.2.16 methylthioadenosine nucleosidase
3.2.2.17 deoxyribodipyrimidine endonucleosidase
3.2.2.18 created 1984, deleted 1989
3.2.2.19 [protein ADP-ribosylarginine] hydrolase
3.2.2.20 DNA-3-methyladenine glycosylase I
3.2.2.21 DNA-3-methyladenine glycosylase II
3.2.2.22 rRNA N-glycosylase
3.2.2.23 DNA-formamidopyrimidine glycosylase
3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase
3.2.2.25 N-methyl nucleosidase
3.2.2.26 futalosine hydrolase
3.2.2.27 uracil-DNA glycosylase
3.2.2.28 double-stranded uracil-DNA glycosylase
3.2.2.29 thymine-DNA glycosylase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.31 adenine glycosylase
3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases