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EC 3.5.1.97 Details
EC number
3.5.1.97
Accepted name
acyl-homoserine-lactone acylase
Reaction
an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate
Other name(s)
acyl-homoserine lactone acylase, AHL-acylase, AiiD, N-acyl-homoserine lactone acylase, PA2385 protein, quorum-quenching AHL acylase, quorum-quenching enzyme, QuiP
Systematic name
N-acyl-L-homoserine-lactone amidohydrolase
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3′-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity.
History
created 2007
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.1 asparaginase
3.5.1.2 glutaminase
3.5.1.3 ω-amidase
3.5.1.4 amidase
3.5.1.5 urease
3.5.1.6 β-ureidopropionase
3.5.1.7 ureidosuccinase
3.5.1.8 formylaspartate deformylase
3.5.1.9 arylformamidase
3.5.1.10 formyltetrahydrofolate deformylase
3.5.1.11 penicillin amidase
3.5.1.12 biotinidase
3.5.1.13 aryl-acylamidase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.15 aspartoacylase
3.5.1.16 acetylornithine deacetylase
3.5.1.17 acyl-lysine deacylase
3.5.1.18 succinyl-diaminopimelate desuccinylase
3.5.1.19 nicotinamidase
3.5.1.20 citrullinase
3.5.1.21 N-acetyl-β-alanine deacetylase
3.5.1.22 pantothenase
3.5.1.23 ceramidase
3.5.1.24 choloylglycine hydrolase
3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase
3.5.1.26 N4-(β-N-acetylglucosaminyl)-L-asparaginase
3.5.1.27 N-formylmethionylaminoacyl-tRNA deformylase
3.5.1.28 N-acetylmuramoyl-L-alanine amidase
3.5.1.29 2-(acetamidomethylene)succinate hydrolase
3.5.1.30 5-aminopentanamidase
3.5.1.31 formylmethionine deformylase
3.5.1.32 hippurate hydrolase
3.5.1.33 N-acetylglucosamine deacetylase
3.5.1.34 created 1972, deleted 1981
3.5.1.35 D-glutaminase
3.5.1.36 N-methyl-2-oxoglutaramate hydrolase
3.5.1.37 created 1972, deleted 1976
3.5.1.38 glutamin-(asparagin-)ase
3.5.1.39 alkylamidase
3.5.1.40 acylagmatine amidase
3.5.1.41 chitin deacetylase
3.5.1.42 nicotinamide-nucleotide amidase
3.5.1.43 peptidyl-glutaminase
3.5.1.44 protein-glutamine glutaminase
3.5.1.45 created 1978, deleted 1986
3.5.1.46 6-aminohexanoate-oligomer exohydrolase
3.5.1.47 N-acetyldiaminopimelate deacetylase
3.5.1.48 acetylspermidine deacetylase
3.5.1.49 formamidase
3.5.1.50 pentanamidase
3.5.1.51 4-acetamidobutyryl-CoA deacetylase
3.5.1.52 peptide-N4-(N-acetyl-β-glucosaminyl)asparagine amidase
3.5.1.53 N-carbamoylputrescine amidase
3.5.1.54 allophanate hydrolase
3.5.1.55 long-chain-fatty-acyl-glutamate deacylase
3.5.1.56 N,N-dimethylformamidase
3.5.1.57 tryptophanamidase
3.5.1.58 N-benzyloxycarbonylglycine hydrolase
3.5.1.59 N-carbamoylsarcosine amidase
3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase
3.5.1.61 mimosinase
3.5.1.62 acetylputrescine deacetylase
3.5.1.63 4-acetamidobutyrate deacetylase
3.5.1.64 Nα-benzyloxycarbonylleucine hydrolase
3.5.1.65 theanine hydrolase
3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
3.5.1.67 4-methyleneglutaminase
3.5.1.68 N-formylglutamate deformylase
3.5.1.69 glycosphingolipid deacylase
3.5.1.70 aculeacin-A deacylase
3.5.1.71 N-feruloylglycine deacylase
3.5.1.72 D-benzoylarginine-4-nitroanilide amidase
3.5.1.73 carnitinamidase
3.5.1.74 chenodeoxycholoyltaurine hydrolase
3.5.1.75 urethanase
3.5.1.76 arylalkyl acylamidase
3.5.1.77 N-carbamoyl-D-amino-acid hydrolase
3.5.1.78 glutathionylspermidine amidase
3.5.1.79 phthalyl amidase
3.5.1.80 created 1999, deleted 2002
3.5.1.81 N-acyl-D-amino-acid deacylase
3.5.1.82 N-acyl-D-glutamate deacylase
3.5.1.83 N-acyl-D-aspartate deacylase
3.5.1.84 biuret amidohydrolase
3.5.1.85 (S)-N-acetyl-1-phenylethylamine hydrolase
3.5.1.86 mandelamide amidase
3.5.1.87 N-carbamoyl-L-amino-acid hydrolase
3.5.1.88 peptide deformylase
3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase
3.5.1.90 adenosylcobinamide hydrolase
3.5.1.91 N-substituted formamide deformylase
3.5.1.92 pantetheine hydrolase
3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase
3.5.1.94 γ-glutamyl-γ-aminobutyrate hydrolase
3.5.1.95 N-malonylurea hydrolase
3.5.1.96 succinylglutamate desuccinylase
3.5.1.97 acyl-homoserine-lactone acylase
3.5.1.98 histone deacetylase
3.5.1.99 fatty acid amide hydrolase
3.5.1.100 (R)-amidase
3.5.1.101 L-proline amide hydrolase
3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5′-monophosphate deformylase
3.5.1.103 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase
3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylase
3.5.1.105 chitin disaccharide deacetylase
3.5.1.106 N-formylmaleamate deformylase
3.5.1.107 maleamate amidohydrolase
3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase
3.5.1.109 sphingomyelin deacylase
3.5.1.110 ureidoacrylate amidohydrolase
3.5.1.111 2-oxoglutaramate amidase
3.5.1.112 2′-N-acetylparomamine deacetylase
3.5.1.113 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase
3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase
3.5.1.115 mycothiol S-conjugate amidase
3.5.1.116 ureidoglycolate amidohydrolase
3.5.1.117 6-aminohexanoate-oligomer endohydrolase
3.5.1.118 γ-glutamyl hercynylcysteine S-oxide hydrolase
3.5.1.119 Pup amidohydrolase
3.5.1.120 2-aminomuconate deaminase (2-hydroxymuconate-forming)
3.5.1.121 protein N-terminal asparagine amidohydrolase
3.5.1.122 protein N-terminal glutamine amidohydrolase
3.5.1.123 γ-glutamylanilide hydrolase
3.5.1.124 protein deglycase
3.5.1.125 N2-acetyl-L-2,4-diaminobutanoate deacetylase
3.5.1.126 oxamate amidohydrolase
3.5.1.127 jasmonoyl-L-amino acid hydrolase
3.5.1.128 deaminated glutathione amidase
3.5.1.129 N5-(cytidine 5′-diphosphoramidyl)-L-glutamine hydrolase
3.5.1.130 [amino group carrier protein]-lysine hydrolase
3.5.1.131 1-carboxybiuret hydrolase
3.5.1.132 [amino group carrier protein]-ornithine hydrolase
3.5.1.133 Nα-acyl-L-glutamine aminoacylase
3.5.1.134 (indol-3-yl)acetyl-L-aspartate hydrolase
3.5.1.135 N4-acetylcytidine amidohydrolase
3.5.1.136 N,N′-diacetylchitobiose non-reducing end deacetylase
3.5.1.137 N-methylcarbamate hydrolase
3.5.2 In cyclic amides
3.5.3 In linear amidines
3.5.4 In cyclic amidines
3.5.5 In nitriles
3.5.99 In other compounds
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.2 In sulfonyl-containing anhydrides
3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.4.1 myosin ATPase
3.6.4.2 dynein ATPase
3.6.4.3 microtubule-severing ATPase
3.6.4.4 plus-end-directed kinesin ATPase
3.6.4.5 minus-end-directed kinesin ATPase
3.6.4.6 vesicle-fusing ATPase
3.6.4.7 peroxisome-assembly ATPase
3.6.4.8 proteasome ATPase
3.6.4.9 chaperonin ATPase
3.6.4.10 non-chaperonin molecular chaperone ATPase
3.6.4.11 nucleoplasmin ATPase
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase
3.6.5 Acting on GTP to facilitate cellular and subcellular movement
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases