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EC 1.3.8.1 Details
EC number
1.3.8.1
Accepted name
short-chain acyl-CoA dehydrogenase
Reaction
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Other name(s)
butyryl-CoA dehydrogenase,
butanoyl-CoA dehydrogenase,
butyryl dehydrogenase,
unsaturated acyl-CoA reductase,
ethylene reductase,
enoyl-coenzyme A reductase,
unsaturated acyl coenzyme A reductase,
butyryl coenzyme A dehydrogenase,
short-chain acyl CoA dehydrogenase,
short-chain acyl-coenzyme A dehydrogenase,
3-hydroxyacyl CoA reductase,
butanoyl-CoA:(acceptor) 2,3-oxidoreductase,
ACADS (gene name).
Systematic name
short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
CAS registry number
9027-88-7
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
created 1961 as EC 1.3.2.1, transferred 1964 to EC 1.3.99.2, transferred 2011 to EC 1.3.8.1, modified 2012
EC Tree
1.14.11.5 created 1972, deleted 1976