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EC 1.5.3.14 Details

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EC number

1.5.3.14

Accepted name

polyamine oxidase (propane-1,3-diamine-forming)

Reaction

spermidine + O₂ + H₂O = propane-1,3-diamine + 4-aminobutanal + H₂O₂

Other name(s)

MPAO (ambiguous), maize PAO

Systematic name

spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming)

Comment

As the products of the reaction cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines [1]. This enzyme less efficiently catalyses the oxidation of N¹-acetylspermine and spermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N¹-acetylpolyamine oxidase), EC 1.5.3.15 [N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase).

History

created 2009

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.1.99.1 choline dehydrogenase

1.1.99.2 L-2-hydroxyglutarate dehydrogenase

1.1.99.3 gluconate 2-dehydrogenase (acceptor)

1.1.99.4 dehydrogluconate dehydrogenase

1.1.99.5 glycerol-3-phosphate dehydrogenase

1.1.99.6 D-lactate dehydrogenase (acceptor)

1.1.99.7 lactate—malate transhydrogenase

1.1.99.8 alcohol dehydrogenase (acceptor)

1.1.99.9 pyridoxine 5-dehydrogenase

1.1.99.10 glucose dehydrogenase (acceptor)

1.1.99.11 fructose 5-dehydrogenase

1.1.99.12 sorbose dehydrogenase

1.1.99.13 glucoside 3-dehydrogenase (acceptor)

1.1.99.14 glycolate dehydrogenase

1.1.99.15 created 1978, deleted 1980

1.1.99.16 malate dehydrogenase (acceptor)

1.1.99.17 created 1982, deleted 2003

1.1.99.18 cellobiose dehydrogenase (acceptor)

1.1.99.19 uracil dehydrogenase

1.1.99.20 alkan-1-ol dehydrogenase (acceptor)

1.1.99.21 D-sorbitol dehydrogenase (acceptor)

1.1.99.22 glycerol dehydrogenase (acceptor)

1.1.99.23 polyvinyl-alcohol dehydrogenase (acceptor)

1.1.99.24 hydroxyacid-oxoacid transhydrogenase

1.1.99.25 quinate dehydrogenase (pyrroloquinoline-quinone)

1.1.99.26 3-hydroxycyclohexanone dehydrogenase

1.1.99.27 (R)-pantolactone dehydrogenase (flavin)

1.1.99.28 glucose-fructose oxidoreductase

1.1.99.29 pyranose dehydrogenase (acceptor)

1.1.99.30 2-oxo-acid reductase

1.1.99.31 (S)-mandelate dehydrogenase

1.1.99.32 L-sorbose 1-dehydrogenase

1.1.99.33 formate dehydrogenase (acceptor)

1.1.99.34 glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)

1.1.99.35 soluble quinoprotein glucose dehydrogenase

1.1.99.36 alcohol dehydrogenase (nicotinoprotein)

1.1.99.37 methanol dehydrogenase (nicotinoprotein)

1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

1.1.99.39 D-2-hydroxyglutarate dehydrogenase

1.1.99.40 (R)-2-hydroxyglutarate—pyruvate transhydrogenase

1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase

1.1.99.42 4-pyridoxic acid dehydrogenase

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.3 With oxygen as acceptor

1.5.3.1 sarcosine oxidase (formaldehyde-forming)

1.5.3.2 N-methyl-L-amino-acid oxidase

1.5.3.3 created 1961, deleted 1972

1.5.3.4 N⁶-methyl-lysine oxidase

1.5.3.5 (S)-6-hydroxynicotine oxidase

1.5.3.6 (R)-6-hydroxynicotine oxidase

1.5.3.7 L-pipecolate oxidase

1.5.3.8 created 1989, deleted 1992

1.5.3.9 created 1989, modified 1999, deleted 2002

1.5.3.10 dimethylglycine oxidase

1.5.3.11 polyamine oxidase

1.5.3.12 dihydrobenzophenanthridine oxidase

1.5.3.13 N¹-acetylpolyamine oxidase

1.5.3.14 polyamine oxidase (propane-1,3-diamine-forming)

1.5.3.15 N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)

1.5.3.16 spermine oxidase

1.5.3.17 non-specific polyamine oxidase

1.5.3.18 L-saccharopine oxidase

1.5.3.19 4-methylaminobutanoate oxidase (formaldehyde-forming)

1.5.3.20 N-alkylglycine oxidase

1.5.3.21 4-methylaminobutanoate oxidase (methylamine-forming)

1.5.3.22 coenzyme F₄₂₀H₂ oxidase

1.5.3.23 glyphosate oxidoreductase

1.5.3.24 sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)

1.5.3.25 fructosyl amine oxidase (glucosone-forming)

1.5.3.26 fructosyl amine oxidase (fructosamine-forming)

1.5.4 With a disulfide as acceptor

1.5.5 With a quinone or similar compound as acceptor

1.5.7 With an iron-sulfur protein as acceptor

1.5.8 With a flavin or flavoprotein as acceptor

1.5.98 With other, known, physiological acceptors

1.5.99 With unknown physiological acceptors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)