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EC 3.6.1.55 Details
EC number
3.6.1.55
Accepted name
8-oxo-dGTP diphosphatase
Reaction
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
Other name(s)
MutT, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase
Systematic name
8-oxo-dGTP diphosphohydrolase
Comment
This enzyme hydrolyses the phosphoanhydride bond between the α and β phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+.
History
created 2011
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.1 inorganic diphosphatase
3.6.1.2 trimetaphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.4 created 1961, deleted 1965
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.7 acylphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.10 endopolyphosphatase
3.6.1.11 exopolyphosphatase
3.6.1.12 dCTP diphosphatase
3.6.1.13 ADP-ribose diphosphatase
3.6.1.14 adenosine-tetraphosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.16 CDP-glycerol diphosphatase
3.6.1.17 bis(5′-nucleosyl)-tetraphosphatase (asymmetrical)
3.6.1.18 FAD diphosphatase
3.6.1.19 nucleoside-triphosphate diphosphatase
3.6.1.20 5′-acylphosphoadenosine hydrolase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.24 nucleoside phosphoacylhydrolase
3.6.1.25 triphosphatase
3.6.1.26 CDP-diacylglycerol diphosphatase
3.6.1.27 undecaprenyl-diphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.29 bis(5′-adenosyl)-triphosphatase
3.6.1.30 m7G(5′)pppN diphosphatase
3.6.1.31 phosphoribosyl-ATP diphosphatase
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.39 thymidine-triphosphatase
3.6.1.40 guanosine-5′-triphosphate,3′-diphosphate phosphatase
3.6.1.41 bis(5′-nucleosyl)-tetraphosphatase (symmetrical)
3.6.1.42 guanosine-diphosphatase
3.6.1.43 dolichyldiphosphatase
3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003
3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.56 2-hydroxy-dATP diphosphatase
3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
3.6.1.58 8-oxo-dGDP phosphatase
3.6.1.59 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase
3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)
3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)
3.6.1.62 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
3.6.1.63 α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
3.6.1.64 inosine diphosphate phosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.66 XTP/dITP diphosphatase
3.6.1.67 dihydroneopterin triphosphate diphosphatase
3.6.1.68 geranyl diphosphate phosphohydrolase
3.6.1.69 8-oxo-(d)GTP phosphatase
3.6.1.70 guanosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.71 adenosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.72 DNA-3′-diphospho-5′-guanosine diphosphatase
3.6.1.73 inosine/xanthosine triphosphatase
3.6.1.74 mRNA 5′-phosphatase
3.6.1.75 diacylglycerol diphosphate phosphatase
3.6.2 In sulfonyl-containing anhydrides
3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances
3.6.3.1 phospholipid-translocating ATPase
3.6.3.2 Mg2+-importing ATPase
3.6.3.3 Cd2+-exporting ATPase
3.6.3.4 Cu2+-exporting ATPase
3.6.3.5 Zn2+-exporting ATPase
3.6.3.6 H+-exporting ATPase
3.6.3.7 Na+-exporting ATPase
3.6.3.8 Ca2+-transporting ATPase
3.6.3.9 Na+/K+-exchanging ATPase
3.6.3.10 H+/K+-exchanging ATPase
3.6.3.11 Cl--transporting ATPase
3.6.3.12 K+-transporting ATPase
3.6.3.13 created 2000, deleted 2001
3.6.3.14 H+-transporting two-sector ATPase
3.6.3.15 Na+-transporting two-sector ATPase
3.6.3.16 arsenite-transporting ATPase
3.6.3.17 monosaccharide-transporting ATPase
3.6.3.18 oligosaccharide-transporting ATPase
3.6.3.19 maltose-transporting ATPase
3.6.3.20 glycerol-3-phosphate-transporting ATPase
3.6.3.21 polar-amino-acid-transporting ATPase
3.6.3.22 nonpolar-amino-acid-transporting ATPase
3.6.3.23 oligopeptide-transporting ATPase
3.6.3.24 nickel-transporting ATPase
3.6.3.25 sulfate-transporting ATPase
3.6.3.26 nitrate-transporting ATPase
3.6.3.27 phosphate-transporting ATPase
3.6.3.28 phosphonate-transporting ATPase
3.6.3.29 molybdate-transporting ATPase
3.6.3.30 Fe3+-transporting ATPase
3.6.3.31 polyamine-transporting ATPase
3.6.3.32 quaternary-amine-transporting ATPase
3.6.3.33 vitamin B12-transporting ATPase
3.6.3.34 iron-chelate-transporting ATPase
3.6.3.35 manganese-transporting ATPase
3.6.3.36 taurine-transporting ATPase
3.6.3.37 guanine-transporting ATPase
3.6.3.38 capsular-polysaccharide-transporting ATPase
3.6.3.39 lipopolysaccharide-transporting ATPase
3.6.3.40 teichoic-acid-transporting ATPase
3.6.3.41 heme-transporting ATPase
3.6.3.42 β-glucan-transporting ATPase
3.6.3.43 peptide-transporting ATPase
3.6.3.44 xenobiotic-transporting ATPase
3.6.3.45 steroid-transporting ATPase
3.6.3.46 cadmium-transporting ATPase
3.6.3.47 fatty-acyl-CoA-transporting ATPase
3.6.3.48 α-factor-transporting ATPase
3.6.3.49 channel-conductance-controlling ATPase
3.6.3.50 protein-secreting ATPase
3.6.3.51 mitochondrial protein-transporting ATPase
3.6.3.52 chloroplast protein-transporting ATPase
3.6.3.53 Ag+-exporting ATPase
3.6.3.54 Cu+-exporting ATPase
3.6.3.55 tungstate-importing ATPase
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.5 Acting on GTP to facilitate cellular and subcellular movement
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases