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Information on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.55 8-oxo-dGTP diphosphatase
IUBMB Comments
This enzyme hydrolyses the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) . Requires Mg2+.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
nudt1, cimutt, mutt homologue 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
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PATHWAY SOURCE
PATHWAYS
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