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Information on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.56 2-hydroxy-dATP diphosphatase
IUBMB Comments
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
hmth1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate
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