6.3.2.10: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase, go to the full flat file.

Word Map on EC 6.3.2.10

6.3.2.10

atrophy

atrogin-1

ligases

wasting

muscle-specific

myotubes

proteasome

fiber

mafbx

gastrocnemius

ubiquitin-proteasome

hypertrophy

myostatin

soleus

disuse

cachexia

denervation

myosin

sarcopenia

atrogenes

myogenin

forkhead

myod

atrophy-related

tibialis

foxo3a

hindlimb

igf-1

myofiber

unloading

cachectic

vastus

denervation-induced

finger-1

dexamethasone-induced

lateralis

myofibrillar

ring-finger

medicine

drug development

gabarapl1

e3-ligases

autophagy-lysosome

pharmacology

immobilization-induced

e3-ubiquitin

murfs

sarcomeric

slow-twitch

muscle-wasting

3-methylhistidine

Reaction

UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

Synonyms

AbMurF, ATP-dependent UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase, D-Ala-D-Ala-adding enzyme, More, MurF, MurF1, Synthetase, uridine diphosphoacetylmuramoylpentapeptide, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase, UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase, UDPacetylmuramoylpentapeptide synthetase, Uridine diphosphoacetylmuramoylpentapeptide synthetase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.10 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase

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Results	in table
6	Activating Compound
36641	AA Sequence
5	Application
1	CAS Registry Number
10	Cloned(Commentary)
5	Cofactor
4	Crystallization (Commentary)
6	General Information
38	IC50 Value
56	Inhibitors
5	Localization
3	Metals/Ions
14	Natural Substrates/ Products (Substrates)
28	Organism
8	Pathway
12	PDB ID
1	pH Optimum
9	Protein Variants
4	Purification (Commentary)
2	Reaction
10	Reaction Type
23	Reference
4	Source Tissue
23	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
3	Subunits
47	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase

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ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala

2 entries

ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala

ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

5 entries

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine

ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

4 entries

additional information

Escherichia coli

P11880

the specific activity of the mutant enzyme is highly reduced compared to the wild-type murF

649829