6.3.2.10: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase, go to the full flat file.
Word Map on EC 6.3.2.10
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6.3.2.10
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atrophy
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atrogin-1
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ligases
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wasting
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muscle-specific
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myotubes
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proteasome
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fiber
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mafbx
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gastrocnemius
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ubiquitin-proteasome
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hypertrophy
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myostatin
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soleus
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disuse
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cachexia
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denervation
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myosin
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sarcopenia
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atrogenes
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myogenin
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forkhead
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myod
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atrophy-related
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tibialis
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foxo3a
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hindlimb
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igf-1
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myofiber
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unloading
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cachectic
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vastus
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denervation-induced
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finger-1
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dexamethasone-induced
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lateralis
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myofibrillar
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ring-finger
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medicine
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drug development
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gabarapl1
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e3-ligases
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autophagy-lysosome
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pharmacology
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immobilization-induced
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e3-ubiquitin
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murfs
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sarcomeric
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slow-twitch
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muscle-wasting
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3-methylhistidine
- 6.3.2.10
- atrophy
-
atrogin-1
- ligases
- wasting
-
muscle-specific
- myotubes
- proteasome
- fiber
-
mafbx
-
gastrocnemius
-
ubiquitin-proteasome
- hypertrophy
-
myostatin
- soleus
-
disuse
-
cachexia
-
denervation
- myosin
- sarcopenia
-
atrogenes
-
myogenin
-
forkhead
- myod
-
atrophy-related
- tibialis
-
foxo3a
- hindlimb
- igf-1
-
myofiber
-
unloading
-
cachectic
-
vastus
-
denervation-induced
-
finger-1
-
dexamethasone-induced
- lateralis
-
myofibrillar
-
ring-finger
- medicine
- drug development
-
gabarapl1
-
e3-ligases
-
autophagy-lysosome
- pharmacology
-
immobilization-induced
-
e3-ubiquitin
-
murfs
-
sarcomeric
-
slow-twitch
-
muscle-wasting
- 3-methylhistidine
Reaction
Synonyms
AbMurF, ATP-dependent UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase, D-Ala-D-Ala-adding enzyme, More, MurF, MurF1, Synthetase, uridine diphosphoacetylmuramoylpentapeptide, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase, UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase, UDPacetylmuramoylpentapeptide synthetase, Uridine diphosphoacetylmuramoylpentapeptide synthetase
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General Information
General Information on EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
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metabolism
physiological function
MurF is the enzyme responsible for the last step in the biosynthesis of UDP-N-acetylmuramyl-pentapeptide, the monomeric precursor of peptidoglycan
metabolism
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MurF is the enzyme responsible for the last step in the biosynthesis of UDP-N-acetylmuramyl-pentapeptide, the monomeric precursor of peptidoglycan
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MurF adds D-Ala-D-Ala dipeptide to UDP-N-acetylmuramyl-L-Ala-c-D-Glu-m-DAP (or L-Lys) in an ATP-dependent manner, which is the last step in the biosynthesis of monomeric precursor of peptidoglycan for bacterial cell wall synthesis
physiological function
MurF is the enzyme responsible for the last step in the biosynthesis of UDP-N-acetylmuramyl-pentapeptide, the monomeric precursor of peptidoglycan. MurF catalyzes the addition of D-Ala-D-Ala dipeptide to UDP-N-acetylmuramyl-tripeptide [UDPMurNAc-L-Ala-gamma-D-Glu-m-DAP(or L-Lys)] in an ATP-dependent manner. The gamma-phosphate of ATP is transferred to the C-terminal carboxylate of UDP-N-acetylmuramyl-tripeptide to form an acyl phosphate intermediate, which is subsequently attacked by the amino group of the incoming dipeptide to form a peptide bond in a non-ribosomal fashion
physiological function
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MurF is the enzyme responsible for the last step in the biosynthesis of UDP-N-acetylmuramyl-pentapeptide, the monomeric precursor of peptidoglycan. MurF catalyzes the addition of D-Ala-D-Ala dipeptide to UDP-N-acetylmuramyl-tripeptide [UDPMurNAc-L-Ala-gamma-D-Glu-m-DAP(or L-Lys)] in an ATP-dependent manner. The gamma-phosphate of ATP is transferred to the C-terminal carboxylate of UDP-N-acetylmuramyl-tripeptide to form an acyl phosphate intermediate, which is subsequently attacked by the amino group of the incoming dipeptide to form a peptide bond in a non-ribosomal fashion
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physiological function
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MurF adds D-Ala-D-Ala dipeptide to UDP-N-acetylmuramyl-L-Ala-c-D-Glu-m-DAP (or L-Lys) in an ATP-dependent manner, which is the last step in the biosynthesis of monomeric precursor of peptidoglycan for bacterial cell wall synthesis
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