6.3.1.14: diphthine-ammonia ligase

This is an abbreviated version!
For detailed information about diphthine-ammonia ligase, go to the full flat file.

Reaction

Synonyms

Diphthamide synthase, diphthamide synthetase, DPH6, EC 6.3.2.22, Synthetase, diphthamide, YLR143w

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.14 diphthine-ammonia ligase

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5793	AA Sequence
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12	General Information
2	Metals/Ions
5	Natural Substrates/ Products (Substrates)
13	Organism
2	Pathway
2	Protein Variants
2	Purification (Commentary)
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17	Substrates and Products (Substrate)
14	Synonyms
1	Systematic Name
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Systematic Name

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Systematic Name on EC 6.3.1.14 - diphthine-ammonia ligase

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SYSTEMATIC NAME

IUBMB Comments

diphthine-[translation elongation factor 2]:ammonia ligase (AMP-forming)

This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase.