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6.3.1.14: diphthine-ammonia ligase

This is an abbreviated version!
For detailed information about diphthine-ammonia ligase, go to the full flat file.

Reaction

ATP
+
diphthine-[translation elongation factor 2]
+
NH3
=
AMP
+
diphosphate
+
diphthamide-[translation elongation factor 2]

Synonyms

Diphthamide synthase, diphthamide synthetase, DPH6, EC 6.3.2.22, Synthetase, diphthamide, YLR143w

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.14 diphthine-ammonia ligase

Reference

Reference on EC 6.3.1.14 - diphthine-ammonia ligase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moehring, J.M.; Moehring, T.J.
The post-translational trimethylation of diphthamide studied in vitro
J. Biol. Chem.
263
3840-3844
1988
Cricetulus griseus, Cricetulus griseus CHO-K1
Manually annotated by BRENDA team
Moehring, T.J.; Danley, D.E.; Moehring, J.M.
In vitro biosynthesis of diphthamide, studied with mutant chinese hamster ovary cells resistant to diphtheria toxin
Mol. Cell. Biol.
4
642-650
1984
Cricetulus griseus, Cricetulus griseus CHO-K1
Manually annotated by BRENDA team
Uthman, S.; Baer, C.; Scheidt, V.; Liu, S.; ten Have, S.; Giorgini, F.; Stark, M.J.; Schaffrath, R.
The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network
PLoS Genet.
9
e1003334
2013
Saccharomyces cerevisiae (Q12429)
Manually annotated by BRENDA team
Lin, Z.; Su, X.; Chen, W.; Ci, B.; Zhang, S.; Lin, H.
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis
J. Am. Chem. Soc.
136
6179-6182
2014
Saccharomyces cerevisiae (Q12429), Saccharomyces cerevisiae ATCC 204508 / S288c (Q12429)
Manually annotated by BRENDA team
Schaffrath, R.; Stark, M.J.
Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)
Microb. Cell
1
203-205
2014
Saccharomyces cerevisiae (Q12429), Saccharomyces cerevisiae ATCC 204508 / S288c (Q12429)
Manually annotated by BRENDA team