4.2.1.47: GDP-mannose 4,6-dehydratase
This is an abbreviated version!
For detailed information about GDP-mannose 4,6-dehydratase, go to the full flat file.
Word Map on EC 4.2.1.47
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4.2.1.47
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alginate
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fucosylation
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gdp-l-fucose
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mucoid
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l-fucose
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gdp-4-keto-6-deoxy-d-mannose
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gdp-mannuronic
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gdp-d-rhamnose
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phosphomannomutase
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fucosyltransferase
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gdp-4-keto-6-deoxymannose
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d-rhamnose
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synthesis
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biotechnology
- 4.2.1.47
- alginate
-
fucosylation
- gdp-l-fucose
- mucoid
- l-fucose
- gdp-4-keto-6-deoxy-d-mannose
-
gdp-mannuronic
- gdp-d-rhamnose
- phosphomannomutase
-
fucosyltransferase
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gdp-4-keto-6-deoxymannose
- d-rhamnose
- synthesis
- biotechnology
Reaction
Synonyms
ATCV-1GMD, bceN, Dm-gmd, GDP-alpha-D-mannose 4,6-dehydratase, GDP-D-mannose 4,6-dehydratase, GDP-D-mannose 4-oxido-6-reductase, GDP-D-mannose dehydratase, GDP-D-mannose-4,6-dehydratase, GDP-mannose 4, 6-dehydratase, GDP-mannose 4,6 dehydratase, GDP-mannose 4,6-dehydratase, GDP-mannose dehydratase, GDP-mannose dehydrogenase, GDP-mannose-4,6-dehydratase, GMD, GMDS, guanosine 5'-diphosphate-D-mannose 4,6-dehydratase, Guanosine 5'-diphosphate-D-mannose oxidoreductase, Guanosine diphosphomannose 4,6-dehydratase, Guanosine diphosphomannose oxidoreductase, L-GMD, M-GMD, MUR1, ORF13.7, PBCV-1 GMD, S-GMD
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Systematic Name
Systematic Name on EC 4.2.1.47 - GDP-mannose 4,6-dehydratase
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GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6].