4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase

This is an abbreviated version!
For detailed information about 1,4-dihydroxy-2-naphthoyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

1,4-dihydroxy-2-naphthoate synthetase, 1,4-dihydroxy-2-naphthoyl coenzyme A synthase, 1,4-dihydroxy-2-naphthoyl-CoA synthase, 1,4-dihydroxy-2-naphthoyl-coenzyme synthase, DHNA synthetase, DHNA-CoA synthase, dihydroxynaphthoate synthase, Dihydroxynaphthoic acid synthetase, MenB, naphthoate synthase, naphthoate synthase (MenB), Rv0548c, synthase, 1,4-dihydroxy-2-naphthoate

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase

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Results	in table
14675	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
3	Cofactor
10	Crystallization (Commentary)
9	General Information
2	General Stability
29	IC50 Value
57	Inhibitors
10	kcat/KM [mM/s]
10	Ki Value [mM]
10	KM Value [mM]
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
28	Organism
6	Pathway
142	PDB ID
5	pH Optimum
20	Protein Variants
18	Purification (Commentary)
5	Reaction
6	Reaction Type
26	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
33	Substrates and Products (Substrate)
7	Subunits
42	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 4.1.3.36 - 1,4-dihydroxy-2-naphthoyl-CoA synthase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0024

2-(3-carboxypropyl)-benzoyl-CoA

Mycobacterium tuberculosis

P9WNP5

wild type protein protein, pH 7.0, 25°C

714273

0.04 - 21

2-succinylbenzoyl-CoA

4 entries

0.16 - 7.4

o-succinylbenzoate

4 entries

2.4

o-succinylbenzoyl-CoA

Escherichia coli

-

pH 7.0, 25°C

714273

0.04

2-succinylbenzoyl-CoA

Mycobacterium tuberculosis

P9WNP5

S190A mutant protein, pH 7.0, 25°C

714273

0.07

2-succinylbenzoyl-CoA

Mycobacterium tuberculosis

P9WNP5

D185N mutant protein, pH 7.0, 25°C

714273

0.48

2-succinylbenzoyl-CoA

Mycobacterium tuberculosis

P9WNP5

D185E mutant protein, pH 7.0, 25°C

714273

21

2-succinylbenzoyl-CoA

Mycobacterium tuberculosis

P9WNP5

wild type protein, pH 7.0, 25°C

714273

0.16

o-succinylbenzoate

Escherichia coli

-

pH 7.0, temperature not specified in the publication, mutant R267A

728604

0.18

o-succinylbenzoate

Escherichia coli

-

pH 7.0, temperature not specified in the publication, mutant F270A

728604

0.89

o-succinylbenzoate

Escherichia coli

-

pH 7.0, temperature not specified in the publication, mutant K89A

728604

7.4

o-succinylbenzoate

Escherichia coli

-

pH 7.0, temperature not specified in the publication, wild-type enzyme

728604