3.4.24.60: dactylysin
This is an abbreviated version!
For detailed information about dactylysin, go to the full flat file.
Word Map on EC 3.4.24.60
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3.4.24.60
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metalloendopeptidase
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dibasic
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convertase
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n-arginine
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ectodomain
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factor-like
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adam17
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heparin-binding
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disintegrin
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hb-egf
- 3.4.24.60
- metalloendopeptidase
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dibasic
-
convertase
-
n-arginine
-
ectodomain
-
factor-like
-
adam17
-
heparin-binding
-
disintegrin
-
hb-egf
Reaction
Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-/-Phe- and -Phe-/-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively =
Synonyms
Peptide hormone inactivating endopeptidase, peptide hormone inactivating enzyme, PHIE
ECTree
3.4.24.60 dactylysinAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.4.24.60 - dactylysin
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(24-28)ANF pentapeptide
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i.e. Asn-Ser-Phe-Arg-Tyr, weak, substance P as substrate, inhibits cleavage of Gly9-Leu10 and Phe7-Phe8 bonds
(25-28)ANF tetrapeptide
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i.e. Ser-Phe-Arg-Tyr, weak, substance P as substrate, inhibits cleavage of Gly9-Leu10 and Phe7-Phe8 bonds
CP-96345
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non-peptide agonist of substance P, substance P as substrate, inhibits cleavage of Gly9-Leu10 bond
Pentapeptides reproducing or mimicking the COOH-terminal sequence of ANF
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24-28 ANF as substrate
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RP 67580
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non-peptide agonist of substance P, substance P as substrate, inhibits cleavage of Gly9-Leu10 bond
1,10-phenanthroline
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0.01 or 0.05 mM Zn2+, Ca2+ or Mn2+ fully restores; metalloendopeptidase character
thiorphan
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i.e. 3-mercapto-2-benzyl-propanoylglycine, only at high concentrations, above 0.001 mM
additional information
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no inhibition by N-tosyl-L-Phe chloromethyl ketone (i.e. TPCK); pepstatin, guanidylethylmercaptosuccinic acid (i.e. GEMSA), captopril, aprotinin, soybean trypsin inhibitor (i.e. STI), PMSF, IAA
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additional information
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pepstatin, guanidylethylmercaptosuccinic acid (i.e. GEMSA), captopril, aprotinin, soybean trypsin inhibitor (i.e. STI), PMSF, IAA; retrothiorphan
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