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3.4.24.60: dactylysin

This is an abbreviated version!
For detailed information about dactylysin, go to the full flat file.

Word Map on EC 3.4.24.60

Reaction

Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-/-Phe- and -Phe-/-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively =

Synonyms

Peptide hormone inactivating endopeptidase, peptide hormone inactivating enzyme, PHIE

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.60 dactylysin

Substrates Products

Substrates Products on EC 3.4.24.60 - dactylysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(19-28)ANF peptide + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor derived peptide, cleavage site: Gly20-Leu21
-
-
?
(20-28)ANF peptide + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(21-28)ANF octapeptide + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(22-28)ANF heptapeptide + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(23-28)ANF hexapeptide + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(5-11)Substance P heptapeptide + H2O
?
show the reaction diagram
-
i.e. Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, cleavage site: Gly9-Leu10
-
-
?
(5-28)ANF + H2O
ANF(5-25) + Phe26-Arg27-Tyr28
show the reaction diagram
(6-11)Substance P hexapeptide + H2O
?
show the reaction diagram
-
i.e. Gln-Phe-Phe-Gly-Leu-Met-NH2, cleavage site: Gly9-Leu10
-
-
?
(Arg0,Leu6)-enkephalin + H2O
?
show the reaction diagram
-
cleavage of Phe4-Leu5
-
-
?
(Leu5,Arg6)-enkephalin + H2O
YGGF + Leu-Arg
show the reaction diagram
-
cleavage of Phe4-Leu5
-
-
?
angiotensin II + H2O
?
show the reaction diagram
ANP-(103-126) + H2O
ANP-(103-123) + Phe124-Arg125-Tyr126
show the reaction diagram
-
i.e. atrial natriuretic peptide, cleavage sites: Xaa-Phe, Xaa-Leu or Xaa-Ile bonds
-
?
Antibacterial peptide PGLa + H2O
?
show the reaction diagram
Asp-Ala-Asp-Thr-Cys-[D-Arg8]-kermit + H2O
?
show the reaction diagram
-
model substrate, derivative of kermit, cleavage site: Ser12-Phe13
-
-
?
atrial natriuretic factor + H2O
LGCNS + Phe-Arg-Tyr
show the reaction diagram
-
cleavage of Ser-Phe
-
-
?
atrial natriuretic peptide + H2O
?
show the reaction diagram
-
cleavage at Ser123-Phe124
-
-
?
beta(1-40)Amyloid
?
show the reaction diagram
-
cleavage site: Gly33-Leu34
-
-
?
beta-(1-40)amyloid + H2O
?
show the reaction diagram
-
-
-
-
?
beta-amyloid derived peptide + H2O
?
show the reaction diagram
-
cleavage of Gly-Leu
-
-
?
bradykinin + H2O
?
show the reaction diagram
dynorphin A + H2O
?
show the reaction diagram
-
-
-
-
?
dynorphin A1-16 + H2O
?
show the reaction diagram
-
cleavage of Phe-Leu
-
-
?
kermit + H2O
?
show the reaction diagram
-
cleavage of the peptide link Ser-Phe
-
-
?
Litorin + H2O
?
show the reaction diagram
neurokinin + H2O
?
show the reaction diagram
-
-
-
-
?
Neurokinin A + H2O
?
show the reaction diagram
neurokinin A + H2O
HKTDSFVG + Leu-Met-NH2
show the reaction diagram
-
-
-
-
?
Neuromedin B + H2O
?
show the reaction diagram
-
i.e. Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2, major cleavage site: His8-Phe9, minor site: Gly7-His8
-
-
?
Neuromedin C + H2O
?
show the reaction diagram
peptide PglA + H2O
?
show the reaction diagram
-
antimicrobial peptide of Xenopus laevis skin secretion predominantly cleaved at the Lys12-Ile13 bond
-
-
?
Somatostatin-14 + H2O
?
show the reaction diagram
Substance P + H2O
?
show the reaction diagram
substance P + H2O
RPKQQF + Phe-Gly + Leu-Met-NH2
show the reaction diagram
-
cleavage of Gly9-Leu10
-
-
?
[Arg0,Leu5,Arg6]enkephalin + H2O
?
show the reaction diagram
-
heptapeptide Arg-Tyr-Gly-Gly-Phe-Leu-Arg, cleavage site: Phe5-Leu6
-
-
?
[Arg0,Leu5]enkephalin + H2O
?
show the reaction diagram
-
hexapeptide Arg-Tyr-Gly-Gly-Phe-Leu, cleavage site: Phe4-Leu5
-
-
?
[D-Arg8]-kermit + H2O
?
show the reaction diagram
-
model substrate, derivative of kermit i.e. Asp-Val-Asp-Glu-Arg-Asp-Val-Arg-Gly-Phe-Ala-Ser-Phe-Leu-NH2, cleavage site: Ser12-Phe13
-
-
?
[Ile26](21-28)ANF octapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
[Leu26](21-28)ANF octapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
[Leu5,Arg6]enkephalin + H2O
?
show the reaction diagram
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Arg, cleavage site: Phe4-Leu5
-
-
?
[Leu5,Ile6]enkephalin + H2O
?
show the reaction diagram
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Ile, cleavage site: Phe4-Leu5
-
-
?
[Leu5,Lys6]enkephalin + H2O
?
show the reaction diagram
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Lys, cleavage site: Phe4-Leu5
-
-
?
[Trp26](21-28)ANF octapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
[Tyr26](21-28)ANF octapeptide + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-