3.4.24.47: horrilysin

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For detailed information about horrilysin, go to the full flat file.

Reaction

Cleavage of only the single bond Ala14-/-Leu in the insulin B chain, Ser12-/-Leu in the A chain, and Ile-/-Gly, Pro-/-Ala, and Ser-/-Trp in melittin =

Synonyms

Crotalus horridus metalloendopeptidase, Hemorrhagic proteinase IV, HP-IV, Proteinase, Crotalus horridus horridus venom hemorrhagic

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.47 horrilysin

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Results	in table
1	Application
1	CAS Registry Number
2	General Stability
4	Inhibitors
7	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
2	pH Optimum
1	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
3	Source Tissue
1	Storage Stability
31	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.4.24.47 - horrilysin

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

Crotalus horridus horridus

-

-

31286

dithiothreitol

Crotalus horridus horridus

-

-

31286

EDTA

Crotalus horridus horridus

-

-

31286

additional information

Crotalus horridus horridus

-

no inhibition by alpha1-antitrypsin, N-ethylmaleimide, iodoacetamide, phenylmethylsulfonylfluoride, egg white or soybean trypsin inhibitor

31286

-