3.4.24.47: horrilysin
This is an abbreviated version!
For detailed information about horrilysin, go to the full flat file.
Reaction
Cleavage of only the single bond Ala14-/-Leu in the insulin B chain, Ser12-/-Leu in the A chain, and Ile-/-Gly, Pro-/-Ala, and Ser-/-Trp in melittin =
Synonyms
Crotalus horridus metalloendopeptidase, Hemorrhagic proteinase IV, HP-IV, Proteinase, Crotalus horridus horridus venom hemorrhagic
ECTree
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Metals Ions
Metals Ions on EC 3.4.24.47 - horrilysin
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Ca2+
Zn2+
Ca2+
-
zinc and calcium containing metalloproteinase, no activation by added Ca2+
Zn2+
-
activation, 1 mM Zn2+ doubles activity vs. glomerulus basement membrane preparation