3.1.4.14: [acyl-carrier-protein] phosphodiesterase
This is an abbreviated version!
For detailed information about [acyl-carrier-protein] phosphodiesterase, go to the full flat file.
Word Map on EC 3.1.4.14
Reaction
Synonyms
4'-phosphopantetheine hydrolase, ACP hydrolase, ACP hydrolyase, ACP phosphodiesterase, AcpH, acyl carrier protein phosphodiesterase, holofatty acid synthetase hydrolase
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3.1.4.14 [acyl-carrier-protein] phosphodiesteraseAdvanced search results
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Substrates Products on EC 3.1.4.14 - [acyl-carrier-protein] phosphodiesterase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-carrier protein domain of the iterative polyketide synthase in calicheamicin biosynthesis + H2O
?
acyl-carrier protein from Escherichia coli fatty acid synthesis pathway + H2O
?
-
complete conversion
-
-
?
acyl-carrier-protein + H2O
4'-phosphopantetheine + apo-[acyl-carrier-protein]
-
-
-
?
Clostridium butyricum acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein acyl-carrier protein
-
-
-
-
?
E. coli acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein of acyl-carrier protein
peptidyl carrier protein domain of non-ribosomal peptide synthase + H2O
?
-
complete conversion
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
-
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
CoA donates 4'-phosphopantetheine as prosthetic group
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
ACP phosphodiesterase activity is not essential for growth, although it is required for turnover of the acyl carrier protein prosthetic group in vivo
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
cleavage of acyl carrier protein species with acyl chains of 6-16 carbon atoms and is active on some non-native acyl carrier protein species. Preference for inacylated acyl carrier proteins and short chain acyl carrier proteins over the medium and long chain species
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
acyl-carrier protein holo-PA2966 is converted completely back to its apo-form within 40 min, whereas the acyl-carrier proteins PA1869 and PA4226 remain in its holo form even after prolonged incubation. Partial conversion is observed for acyl-carrier protein PA3334 with both the apo and holo forms present after the incubation
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
acyl-carrier protein holo-PA2966 is converted completely back to its apo-form within 40 min, whereas the acyl-carrier proteins PA1869 and PA4226 remain in its holo form even after prolonged incubation. Partial conversion is observed for acyl-carrier protein PA3334 with both the apo and holo forms present after the incubation
-
-
?
acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein
-
CoA donates 4'-phosphopantetheine as prosthetic group
-
-
?
acyl-carrier protein domain of the iterative polyketide synthase in calicheamicin biosynthesis + H2O
?
-
partial conversion
-
-
?
acyl-carrier protein domain of the iterative polyketide synthase in calicheamicin biosynthesis + H2O
?
-
partial conversion
-
-
?
E. coli acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein of acyl-carrier protein
-
-
-
-
?
E. coli acyl-carrier protein + H2O
4'-phosphopantetheine + apoprotein of acyl-carrier protein
-
no activity on large peptides of E. coli acyl-carrier-protein
-
-
?
holo-fatty acid synthetase + H2O
apo-fatty acid synthetase + 4'-phosphopantetheine
-
no activity on coenzyme A
-
-
?
holo-fatty acid synthetase + H2O
apo-fatty acid synthetase + 4'-phosphopantetheine
-
1 mol holo-fatty acid synthetase contains 1 mol 4'-phosphopantetheine
-
-
?
holo-fatty acid synthetase + H2O
apo-fatty acid synthetase + 4'-phosphopantetheine
-
specific for rat liver holo-fatty acid synthetase, no activity on pigeon liver holo-fatty acid synthetase
-
-
?
holo-fatty acid synthetase + H2O
apo-fatty acid synthetase + 4'-phosphopantetheine
-
-
-
-
?
additional information
?
-
-
AcpH readily removes the N-pentylpantothenamide-modified prosthetic group of acyl carrier proteinboth in vivo and in vitro
-
-
?
additional information
?
-
-
acyl-carrier protein domain from the modular polyketide synthase DEBS is a poor substrate for AcpH
-
-
?
additional information
?
-
-
AcpH does not hydrolyze 3',5'-cAMP
-
-
?
additional information
?
-
-
acyl-carrier protein domain from the modular polyketide synthase DEBS is a poor substrate for AcpH
-
-
?
