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3.1.4.14: [acyl-carrier-protein] phosphodiesterase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.14

Reaction

holo-[acyl-carrier protein]
+
H2O
=
4'-phosphopantetheine
+
apo-[acyl-carrier protein]

Synonyms

ACP phosphodiesterase, holofatty acid synthetase hydrolase, 4'-phosphopantetheine hydrolase, ACP hydrolase, acyl carrier protein phosphodiesterase, AcpH, ACP hydrolyase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.14 [acyl-carrier-protein] phosphodiesterase

Systematic Name

Systematic Name on EC 3.1.4.14 - [acyl-carrier-protein] phosphodiesterase

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SYSTEMATIC NAME
IUBMB Comments
holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase.